Development of 3D computational models of biodegradable meshes

Vaz, F.; Silva, Maria Elisabete; Fernandes, António Augusto; Parente, Marco

doi:10.1109/enbeng58165.2023.10175349

2023 IEEE 7th Portuguese Meeting on Bioengineering (ENBENG) 2023

DOI: 10.1109/enbeng58165.2023.10175349

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Development of 3D computational models of biodegradable meshes

F. Vaz

Maria Elisabete Silva

António Augusto Fernandes

et al.

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2024

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Cited by 2 publications

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Optimizing melt electrowriting prototypes for printing non‐medical and medical grade polycaprolactone meshes in prolapse repair

Vaz,

Martins,

Pinheiro

et al. 2024

J of Applied Polymer Sci

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Pelvic organ prolapse (POP) arises from insufficient support of female pelvic organs. Synthetic implants used in treatment can cause complications like infections, mesh shrinkage, and tissue erosion, often due to biomechanical compatibility issues. This research aims to optimize printing parameters for a melt electrowriting process using medical grade biodegradable Poly (ε‐caprolactone) (PCL) with a pellet extruder. The primary goal is to produce meshes with specific characteristics, including square and diagonal shapes, and filament diameters of 80, 160, and 240 μm. These meshes are evaluated through mechanical tests, comparing their performance with a commercially available mesh and sheep vaginal tissue. The mechanical analysis showed that the commercial mesh was 84% stiffer than sheep vaginal tissue at higher strain levels. Non‐medical grade PCL, with 80 μm meshes, closely matched the tissue's mechanical properties, with an 8% variation. Medical‐grade PCL exhibited distinct behavior, with the 80 μm square mesh (two layers) showing a 27% variation and the 160 μm diagonal mesh (one layer) displaying the closest fit at 9%. The findings indicate that 3D‐printed biodegradable meshes, particularly those printed with medical‐grade PCL, may serve as a suitable alternative to mitigate complications associated with commercial implants.

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Optimizing melt electrowriting prototypes for printing non‐medical and medical grade polycaprolactone meshes in prolapse repair

Vaz,

Martins,

Pinheiro

et al. 2024

J of Applied Polymer Sci

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Medical- and Non-Medical-Grade Polycaprolactone Mesh Printing for Prolapse Repair: Establishment of Melt Electrowriting Prototype Parameters

Vaz,

Martins,

Pinheiro

et al. 2024

Applied Sciences

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Pelvic organ prolapse (POP) occurs due to inadequate support of female pelvic organs and is often treated with synthetic implants. However, complications like infections, mesh shrinkage, and tissue erosion can arise due to biomechanical incompatibilities with native tissue. This study aimed to optimize the melt electrowriting process using medical-grade biodegradable Poly(ε-caprolactone) (PCL) with a pellet extruder to print meshes that mimic the mechanical properties of vaginal tissue. Square and diagonal mesh designs with filament diameters of 80 µm, 160 µm, and 240 µm were produced and evaluated through mechanical testing, comparing them to a commercial mesh and sheep vaginal tissue. The results showed that when comparing medical-grade with non-medical-grade square meshes, there was a 54% difference in the Secant modulus, with the non-medical-grade meshes falling short of matching the properties of vaginal tissue. The square-shaped medical-grade PCL mesh closely approximated vaginal tissue, showing only a 13.7% higher Secant modulus and a maximum stress of 0.29 MPa, indicating strong performance. Although the diagonal-shaped mesh exhibited a 14% stress difference, its larger Secant modulus discrepancy of 45% rendered it less suitable. In contrast, the commercial mesh was significantly stiffer, measuring 77.5% higher than vaginal tissue. The diagonal-shaped mesh may better match the stress–strain characteristics of vaginal tissue, but the square-shaped mesh offers stronger support due to its higher stress–strain curve. Overall, meshes printed with medical-grade PCL show superior performance compared to non-medical-grade meshes, suggesting that they are a promising avenue for future advancements in the field of POP repair.

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Development of 3D computational models of biodegradable meshes

Cited by 2 publications

References 7 publications

Optimizing melt electrowriting prototypes for printing non‐medical and medical grade polycaprolactone meshes in prolapse repair

Optimizing melt electrowriting prototypes for printing non‐medical and medical grade polycaprolactone meshes in prolapse repair

Medical- and Non-Medical-Grade Polycaprolactone Mesh Printing for Prolapse Repair: Establishment of Melt Electrowriting Prototype Parameters

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