Development of a chemically stable 10-hydroxycamptothecin nanosuspensions

Pu, Xiaohui; Sun, Jin; Wang, Yan; Wang, Yongjun; Liu, Xiaohong; Zhang, Peng; Tang, Xing; Pan, Weisan; Han, Jie; Zhang, He

doi:10.1016/j.ijpharm.2009.05.062

Cited by 95 publications

(53 citation statements)

References 35 publications

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“…Keck and Muller report that in such a case, drug nanocrystals possess a definite crystalline state (26). In another report of the research work by Pu et al, XRD spectra of lyophilized 10-hydroxy camptothecin nanosuspension, prepared by the combination of microprecipitation and high-pressure homogenization methods, showed the absence of crystalline peaks of the drug indicating its amorphous nature after freeze-drying (13). Results obtained in the current study are in agreement with this report.…”

Section: X-ray Diffraction Studiessupporting

confidence: 92%

“…The patented process uses a combination of precipitation and a second high-energy homogenization step to produce nanosuspensions (12). Pu et al present a preparation of 10-hydroxycamptothecin nanosuspension using microprecipitation and a high-pressure homogenization technique (13). The current study utilizes a combination approach to formulate a stable, uniform SSD nanosuspension.…”

Section: Introductionmentioning

confidence: 99%

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Silver Sulfadiazine Nanosystems for Burn Therapy

Venkataraman

Nagarsenker

2012

AAPS PharmSciTech

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Abstract. The objective of the present study was to formulate stable silver sulfadiazine (SSD) nanosuspensions and nanogels suitable for topical delivery with a view to increase bactericidal activity in burn therapy. SSD nanosuspensions were formulated using the microprecipitation-high-pressure homogenization technique. An optimized microsuspension of 0.5% SSD formulated with 6% Cremophor EL and 4% Lauroglycol 90 was subjected to 30 cycles of 1,000-bar pressure to give a nanosuspension with an average particle size of 367.85 nm. Transmission electron microscopy studies revealed that ovoid-to rectangularshaped SSD particles were present as clusters. It was evident through X-ray diffraction studies that SSD was present in amorphous state both in microprecipitate and in nanosuspension. SSD (0.5%) nanogels were prepared using 1% Carbopol 974 P for topical delivery of nanosized SSD. In vitro release studies demonstrated that SSD release was faster from solutions and nanosuspensions compared to gel formulation owing to the influence of the gel matrix on SSD release. The bacterial inhibitory efficiency of SSD nanosuspension was as good as that of SSD solution against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. In vivo studies revealed that a nanogel containing 0.5% SSD was more effective in wound healing compared to 0.5% and 1% marketed cream.

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Section: X-ray Diffraction Studiessupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Silver Sulfadiazine Nanosystems for Burn Therapy

Venkataraman

Nagarsenker

2012

AAPS PharmSciTech

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“…33,34 As when drug particles are smaller, the corresponding surface area is larger, so the nanoparticles provided a large increase in the surface area. Furthermore, according to the Prandtl equation, 35 the diffusion distance, h, decreases for very small particles. The increase of surface area and the simultaneous decrease of diffusion distance could lead to enhancement in dissolution velocity of the drug.…”

mentioning

confidence: 99%

Process optimization and evaluation of novel baicalin solid nanocrystals

Yue¹,

Liu²,

Wan³

et al. 2013

IJN

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“…It can be produced by top-down process (breaking large drug particles as in media milling and high pressure homogenization), bottom-up process (building up nanoparticles from drug molecules via precipitation), or a combination of both (Pu et al, 2009;Ali et al, 2011). In previous study, 1% (w/v) GLT-NS with particle size of 283 ± 7 nm was successfully prepared by high pressure homogenization technique and the GLT-NS was firstly freeze-dried and then gelled with swelled carbopol 940P, so as to obtain GLT nanogel with drug loading of about 5% (w/ w) (Shen et al, 2014).…”

Section: Preparation Of Glt Nanogelmentioning

confidence: 99%

Therapeutic effects of nanogel containing triterpenoids isolated from Ganoderma lucidum (GLT) using therapeutic ultrasound (TUS) for frostbite in rats

Shen

et al. 2015

Drug Delivery

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(2016) Therapeutic effects of nanogel containing triterpenoids isolated from Ganodermalucidum (GLT) using therapeutic ultrasound (TUS) for frostbite in rats, Drug Delivery, 23:8, 2643-2650, DOI: 10.3109/10717544.2015 Objective: The aim of this study was to evaluate the effect of therapeutic ultrasound (TUS) on dermal delivery and therapeutic effect for frostbite of nanogel containing triterpenoids isolated from Ganoderma lucidum (GLT). Methods: GLT nanosuspension (GLT-NS) was prepared by high pressure homogenization and then suitably gelled to obtain GLT nanogel. The effects of TUS on GLT releasing from GLT nanogel and GLT permeation through the excised rat abdominal skin were evaluated. Moreover, a comparative study was also undertaken between different treatments of frostbite in rats: topical application of GLT nanogel (alone), TUS (alone) and GLT nanogel + TUS (plus).Results: In the in vitro release study, TUS has no influence on drug release from the nanogel.Results of the in vitro transdermal study indicated that TUS significantly increased the cumulative amount of GLT permeating across and into the skin and reduced the lag time in comparison with passive diffusion (without TUS). As evidenced by the significant increase of wound healing area and the improvement in frostbite, TUS applied with simultaneous treatment method could improve the therapeutic effect of the GLT nanogel for frostbite. Conclusion:The present study revealed that the TUS can be effectively used to actively enhance topical delivery of GLT from nanogel and improve the therapeutic effect for frostbite in rats.

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Development of a chemically stable 10-hydroxycamptothecin nanosuspensions

Cited by 95 publications

References 35 publications

Silver Sulfadiazine Nanosystems for Burn Therapy

Silver Sulfadiazine Nanosystems for Burn Therapy

Process optimization and evaluation of novel baicalin solid nanocrystals

Therapeutic effects of nanogel containing triterpenoids isolated from Ganoderma lucidum (GLT) using therapeutic ultrasound (TUS) for frostbite in rats

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