Development of a colorimetric paper fluidic dipstick assay for measurement of glycated albumin to monitor gestational diabetes at the point-of-care

Belsare, Sayali; Coté, Gerard L.

doi:10.1016/j.talanta.2020.121728

Cited by 17 publications

(13 citation statements)

References 24 publications

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“…Globally, there are 425 million people, and this number is expected to rise to 629 million by 2045 [ 130 ]. Gestational DM affects 2% to 14% of pregnant women in the United States each year [ 131 ]. In individuals with DM, there is an increase in the process of non-enzymatic condensation of sugars with nucleic acids, proteins and lipids, which ultimately forms AGEs.…”

Section: Ga: Biomarker and Pathogenetic Factors Of Dmmentioning

confidence: 99%

“…HbA1c is representative of glycemic data for the previous 2–3 months but is not an adequate marker for monitoring ongoing therapy. In mild to moderate gestational DM, when glucose levels can change significantly even during the day, the use of glycated hemoglobin as a marker can disorient the patient and even the doctor [ 131 ]. In addition, under certain conditions, the measurement of HbA1c is unreliable, in particular, for patients with modified red blood cells or renal failure [ 151 , 152 ].…”

Section: Ga: Biomarker and Pathogenetic Factors Of Dmmentioning

confidence: 99%

“…As already mentioned, albumin is synthesized and enters the bloodstream as a non-glycosylated protein, but even in a healthy persons’ blood plasma, a certain proportion of albumin molecules undergo glycation over time, which can affect their structural and functional characteristics [ 155 , 156 ]. According to some reports, in normoglycemic blood 10 to 18% of circulating proteins are glycated in vivo, while in diabetic blood this proportion reaches up to 40% [ 131 , 157 ]. Comparative analysis of various sugars’ ability to interact with BSA in vitro showed that D-galactose is more reactive than D-glucose or D-lactose, although only albumin-lactose conjugates were recognized by specific lectins [ 158 ].…”

Section: Ga: Biomarker and Pathogenetic Factors Of Dmmentioning

confidence: 99%

“…Aptamers with gold nanoparticles were used to carry out colorimetric measurements. Both glycated and non-glycated albumin can be measured in the appropriate physiological concentration ranges—from 50 μM to 300 μM—with a limit of detection (LoD) of 6.5 μM for glycated albumin, and from 500 μM to 750 μM with an LoD of 21 μM for non-glycated albumin [ 131 ].…”

Section: Ga: Biomarker and Pathogenetic Factors Of Dmmentioning

confidence: 99%

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Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties

Belinskaia

Voronina

Шмурак

et al. 2021

IJMS

163

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Being one of the main proteins in the human body and many animal species, albumin plays a decisive role in the transport of various ions—electrically neutral and charged molecules—and in maintaining the colloidal osmotic pressure of the blood. Albumin is able to bind to almost all known drugs, as well as many nutraceuticals and toxic substances, largely determining their pharmaco- and toxicokinetics. Albumin of humans and respective representatives in cattle and rodents have their own structural features that determine species differences in functional properties. However, albumin is not only passive, but also an active participant of pharmacokinetic and toxicokinetic processes, possessing a number of enzymatic activities. Numerous experiments have shown esterase or pseudoesterase activity of albumin towards a number of endogeneous and exogeneous esters. Due to the free thiol group of Cys34, albumin can serve as a trap for reactive oxygen and nitrogen species, thus participating in redox processes. Glycated albumin makes a significant contribution to the pathogenesis of diabetes and other diseases. The interaction of albumin with blood cells, blood vessels and tissue cells outside the vascular bed is of great importance. Interactions with endothelial glycocalyx and vascular endothelial cells largely determine the integrative role of albumin. This review considers the esterase, antioxidant, transporting and signaling properties of albumin, as well as its structural and functional modifications and their significance in the pathogenesis of certain diseases.

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Section: Ga: Biomarker and Pathogenetic Factors Of Dmmentioning

confidence: 99%

Section: Ga: Biomarker and Pathogenetic Factors Of Dmmentioning

confidence: 99%

Section: Ga: Biomarker and Pathogenetic Factors Of Dmmentioning

confidence: 99%

Section: Ga: Biomarker and Pathogenetic Factors Of Dmmentioning

confidence: 99%

See 2 more Smart Citations

Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties

Belinskaia

Voronina

Шмурак

et al. 2021

IJMS

163

View full text Add to dashboard Cite

show abstract

“…Glycated and un-glycated serum albumin were assessed in their physiological concentration ranges (500 to 750 μM for un-glycated serum albumin and 50 to 300 μM for glycated albumin), with a LOD of 21 and 6.5 μM for un-glycated and glycated serum albumin. The use of aptamers as recognition elements, instead of commonly used antibodies, providing not only the required sensitivity, specificity, and dynamic range but also has the added advantage of being stable at room temperature for an extended period, providing the potential for these dipstick tests to be used for GDM monitoring at the point-of-care (POC) [56].…”

Section: Role Of Nanotechnology In Gdm Diagnosismentioning

confidence: 99%

Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review

Barani

Sargazi

Mohammadzadeh

et al. 2021

JFB

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Gestational diabetes mellitus (GDM) is the most frequent complication during pregnancy. This complex disease is characterized by glucose intolerance and consequent hyperglycemia that begins or is first diagnosed in pregnancy, and affects almost 7% of pregnant women. Previous reports have shown that GDM is associated with increased pregnancy complications and might cause abnormal fetal development. At present, treatments are not suitable for the prevention and management of these patients. As an alternative therapeutic opportunity and a leading scientific technique, nanotechnology has helped enlighten the health of these affected women. Theranostic nanomaterials with unique properties and small sizes (at least < 100 nm in one of their dimensions) have been recently engineered for clinics and pharmaceutics. Reducing materials to the nanoscale has successfully changed their properties and enabled them to uniquely interact with cell biomolecules. Several biosensing methods have been developed to monitor glucose levels in GDM patients. Moreover, cerium oxide nanoparticles (NPs), selenium NPs, polymeric NPs, and drug-loaded NPs loaded with therapeutic agents have been used for GDM treatment. Still, there are some challenges associated with the detection limits and toxicity of such nanomaterials. This preliminary review covers the aspects from a fast-developing field to generating nanomaterials and their applications in GDM diagnosis and treatment.

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Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus

et al. 2022

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Purpose of Review Diabetes mellitus is a complex, chronic illness characterized by elevated blood glucose levels that occurs when there is cellular resistance to insulin action, pancreatic β-cells do not produce sufficient insulin, or both. Diabetes prevalence has greatly increased in recent decades; consequently, it is considered one of the fastest-growing public health emergencies globally. Poor blood glucose control can result in long-term micro- and macrovascular complications such as nephropathy, retinopathy, neuropathy, and cardiovascular disease. Individuals with diabetes require continuous medical care, including pharmacological intervention as well as lifestyle and dietary changes. Recent Findings The most common form of diabetes mellitus, type 2 diabetes (T2DM), represents approximately 90% of all cases worldwide. T2DM occurs more often in middle-aged and elderly adults, and its cause is multifactorial. However, its incidence has increased in children and young adults due to obesity, sedentary lifestyle, and inadequate nutrition. This high incidence is also accompanied by an estimated underdiagnosis prevalence of more than 50% worldwide. Implementing successful and cost-effective strategies for systematic screening of diabetes mellitus is imperative to ensure early detection, lowering patients' risk of developing life-threatening disease complications. Therefore, identifying new biomarkers and assay methods for diabetes mellitus to develop robust, non-invasive, painless, highly-sensitive, and precise screening techniques is essential. Summary This review focuses on the recent development of new clinically validated and novel biomarkers as well as the methods for their determination that represent cost-effective alternatives for screening and early diagnosis of T2DM.

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Development of a colorimetric paper fluidic dipstick assay for measurement of glycated albumin to monitor gestational diabetes at the point-of-care

Cited by 17 publications

References 24 publications

Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties

Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties

Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review

Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus

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