Development of a conductivity-based immunosensor for sensitive detection of methamphetamine (stimulant drug) in human urine

Yagiuda, Kaoru; Hemmi, Akihide; Ito, Satoshi; Asano, Yasukazu; Fushinuki, Yoshito; Chen, Chien-Yuan; Karube, Isao

doi:10.1016/0956-5663(96)85920-3

Cited by 71 publications

(37 citation statements)

References 5 publications

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“…This sensor facilitated the determination of phenolic compounds in the nanomolar range. For sensitive detection of methamphetamine, a stimulant drug, in human urine, a conductivitybased immunosensor was developed using anti-methamphetamine antibody [380]. A CL-µTAS device has been developed for determination of atropine and pethidine [381].…”

Section: Sensors For Other Body Constituentsmentioning

confidence: 99%

Current research activity in biosensors

Nakamura

Karube

2003

Analytical and Bioanalytical Chemistry

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261

129

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Biosensors consist of a molecular recognition element and a transducer. Since the first biosensor was developed by Updike and Hicks many biosensors and their associated techniques have been studied and developed. In this review current research activity on the fundamentals and applications of biosensors is summarized. In discussion of the former, molecular recognition elements, techniques and tools for biosensor construction, and basic biosensor devices are introduced. Coverage of the latter includes description of biosensors for environmental, food, and clinical fields. Chemical sensors developed in our laboratory for environmental monitoring are also described. This review mainly summarizes work performed by our group and by our colleagues, and refers to the main review articles summarizing each field of biosensor research in recent years.

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Section: Sensors For Other Body Constituentsmentioning

confidence: 99%

Current research activity in biosensors

Nakamura

Karube

2003

Analytical and Bioanalytical Chemistry

Self Cite

261

129

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“…GLD, a homobifunctional agent, cross-links the amino groups of APTESfunctionalized surfaces to the biomolecule amino groups. 36 Aldehyde groups form imine bonds with amine groups of lysine common to almost every protein or enzyme to form reversible Schiff bases. If necessary, the carbon−nitrogen double bond can be reduced by a reducing agent to produce stable secondary amine linkages.…”

Section: Covalentmentioning

confidence: 99%

“…36 The procedure involves the binding of anti-MA Ab on APTESfunctionalized Pt electrodes using GLD. Therefore, it is applicable for detecting the critical concentration of MA (1 μg mL −1 ) in human urine with high selectivity.…”

Section: −232241mentioning

confidence: 99%

“…Acetone is another popular solvent to silanize carbon nanotubes (CNT, 30 min followed by drying at 60°C), 34 silicon dioxide (5% APTES in acetone), 35 Pt electrodes (0.2% APTES in acetone, 12 h at 120°C), 36 glassy carbon electrodes (GCE, 10% APTES in acetone for 5 h), 37 and optical grating coupler sensor chips. 38 Benzene, 39 anhydrous hexane, 40,41 dimethyl sulfoxide (DMSO)/ethanol, 42 ethanol (under reflux), 43−48 chloroform, 49,50 methanol, 51 and glacial acetic acid/methanol 52 are also useful for silanization.…”

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confidence: 99%

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Immobilization of Antibodies and Enzymes on 3-Aminopropyltriethoxysilane-Functionalized Bioanalytical Platforms for Biosensors and Diagnostics

et al. 2014

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“…Recently, there has been a trend to use conductometric biosensors in combination with nanowires for biosensing [22,23] . The conductometric devices have been successfully used for practical purposes such as pollutant detection in river samples [24] , lactose detection in milk [25] , and drug detection in urine [26] .…”

Section: Conductometric Biosensorsmentioning

confidence: 99%