Development of a controlled release formulation based on a starch matrix system

Cao, Yongsong; Lu, Huang; Chen, Jiuxin; Ji, Liang; Long, Shengyou; Lu, Yitong

doi:10.1016/j.ijpharm.2005.04.005

Cited by 87 publications

(39 citation statements)

References 11 publications

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“…Besides, controlled release of agrochemicals is a possible alternative to surmount chemical pollution derived from their extensive use to increase productivity. Starch and other hydrocolloids, such as alginate or chitosan, have been studied as matrixes for controlled release systems of fertilizers and pesticides .…”

Section: Introductionmentioning

confidence: 99%

Starch‐based films and food coatings: An overview

et al. 2016

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Native and modified starches have received considerable attention for biodegradable films formulation due to their completely biodegradable nature, edible characteristics, and low cost. Development and characterization of starch films obtained by: (i) casting, (ii) blown extrusion and (iii) the thermo-compression moulding process are described. The rheological properties of filmogenic suspensions, the barrier properties, and the mechanical resistance of the obtained films are reported. Addition of specific additives to the formulations modifies the film functionality transforming them into active materials. Diffusion of antimicrobial agents such as potassium sorbate from the active starch film, as well as their efficacy in dairy products is discussed. Likewise, reinforcing agents lead to composite materials with improved mechanical resistance. Starch-based materials show higher permeability to carbon dioxide than to oxygen, which is useful to control the respiration rate of fruits and vegetables. The application of active starch-based coatings to strawberries and Brussels sprouts in order to prolong their refrigerated storage life is analyzed. A detailed overview on the formulation and performance of starch-based films employing industrial and lab-scale methods, as well as the application of starch coatings to improve food quality is presented, with the aim of analyzing the possibility of development and application of such materials.

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Section: Introductionmentioning

confidence: 99%

Starch‐based films and food coatings: An overview

et al. 2016

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“…[2] Substrates such as starch, [10] chitosan, [11] lignin, [12] alginate [13] and synthetic polymers [2] have been examined for producing SRFs. Clays have also been investigated for SRFs synthesis due to their stability, adsorptive capacity and low cost.…”

Section: Introductionmentioning

confidence: 99%

Mobility and efficacy of 2,4-D herbicide from slow-release delivery systems based on organo-zeolite and organo-bentonite complexes

Shirvani

Farajollahi

Bakhtiari

et al. 2014

Journal of Environmental Science and Health, Part B

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This research aimed to develop slow-release formulations (SRFs) of 2,4-dichlorophenoxyacetic acid (2,4-D) using zeolite and bentonite minerals modified with cetyltrimethylammonium (CTMA) surfactant. Adsorption-desorption, greenhouse bioassay and column experiments were carried out to assess the potential of the SRFs to control weeds while reducing the herbicide leaching losses to deep layers of soil. The results showed that only 6.5 mmol 2,4-D kg −1 was retained by Na-bent, and the herbicide was not adsorbed by Na-zeol at all. The surface modification with CTMA surfactant, however, improved the 2,4-D adsorption capacity of the zeolite and bentonite up to 207.5 and 415.8 mmol kg , respectively. The synthesized organo-minerals slowly released the retained 2,4-D discharging 22 to 64% of the adsorbed 2,4-D to the solution phase within 7 days. The SRFs significantly (P = 0.05) reduced the herbicide mobility within the soil columns keeping a great portion of the herbicide active ingredient in the upper 5 cm soil layer. The SRFs were significantly (P = 0.05) as effective as the free technical herbicide in weed control without harming the ryegrass as the main plant. Therefore, the synthesized SRFs could be considered as useful tools for weed control in sustainable agriculture.

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“…The parameters that affect the properties of CR formulations depend on the nature and type of polymer used. In spite of several polymers employed in CR formulations in agriculture, natural polymers such as starch, ethylcellulose, lignin, chitosan, and alginate are preferred to synthetic polymers because of their nontoxic, low cost, free availability, and biodegradability characteristics 6, 12–15…”

Section: Introductionmentioning

confidence: 99%

Lignin and ethylcellulose as polymers in controlled release formulations of urea

Fernández-Pérez

Garrido-Herrera

González‐Pradas

et al. 2008

J of Applied Polymer Sci

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Lignin and ethylcellulose (EC) have been used for the preparation of controlled release (CR) formulations of urea. The lignin matrixes were prepared by mixing the urea with kraft lignin (UL) under melting conditions. They were also crushed and sieved to obtain granules of size between 0.5-1, 1-2, 2-3 and 3-5 mm. The coated urea granules were produced in a Wurster-type fluidized-bed equipment, using an ethanolic solution of EC on two different polymer levels. Having researched the encapsulation efficiency (EE) and the homogeneity of the CR formulations, kinetic-release experiments were carried out in water. A high EE was reached, it oscillated between 95.12% for the system coated with 20% of EC and 97.18% for the 1 mm < d < 2 mm UL system. The rate of urea release from CR granules diminished in all cases in relation to nonformulated urea, being the latter completely dissolved in less than 0.5 h, but it took at least 48 h to release the 90% of urea from the EC coated formulations. Using an empirical equation, the time taken for 50% of the active ingredient to be released into water (T 50 ) was calculated. From the analysis of the T 50 values, we can deduce that the release rate of urea can be controlled mainly by selecting the granule size for lignin CR systems and changing the thickness of the coating film for EC coated granules. The variation order of T 50 values, UL (0.5 mm < d < 1.0 mm) < UL (1.0 mm < d < 2.0 mm) < UL (2.0 mm < d < 3.0 mm) < UL (3.0 mm < d < 5.0 mm) < UEC 10 < UEC 20 , showed that the presence of EC in formulations retarded the release of urea in relation to those prepared with lignin.

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Development of a controlled release formulation based on a starch matrix system

Cited by 87 publications

References 11 publications

Starch‐based films and food coatings: An overview

Starch‐based films and food coatings: An overview

Mobility and efficacy of 2,4-D herbicide from slow-release delivery systems based on organo-zeolite and organo-bentonite complexes

Lignin and ethylcellulose as polymers in controlled release formulations of urea

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