Development of a double‐layer electrospun patch as a potential prenatal treatment for myelomeningocele

Abstract

AbstactMyelomeningocele (MMC) is a congenital defect of the spine characterized by meningeal and spinal cord protrusion through the open vertebral arches. This defect causes progressive prenatal damage of the spinal cord, leading to lifelong handicap. Although midtrimester surgical repair may reduce part of the handicap, an earlier and less invasive approach would further improve the prognosis, possibly minimizing maternal and fetal risks. Several studies have proposed an alternative approach to surgical repair, by covering the defect with a patch and protect the exposed neural tissue. Our study aims to elaborate a waterproof and biodegradable bioactive patch for MMC prenatal fetal repair. We developed a double‐layer patch that can provide a waterproof coverage for the spinal cord, with a bioactive side, conducive to cell proliferation, and an anti‐adhesive side to avoid its attachment to the medulla.This article is protected by copyright. All rights reserved.