Development of a dual-functional Pt–Fe-HAP magnetic nanoparticles application for chemo-hyperthermia treatment of cancer

Tseng, Ching Li; Chang, Kuo-Song; Yeh, Mei Chun; Yang, Kai Chiang; Tang, Tzu Piao; Lin, Feng Huei

doi:10.1016/j.ceramint.2013.09.137

Cited by 43 publications

(20 citation statements)

References 35 publications

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“…CS nanoparticles offer many advantages because of their low toxicity, biodegradability and biocompatibility characteristics (Nagpal et al, 2010). Many studies have shown that asialoglycoprotein receptor (ASGPR), which highly expresses in the surface of hepatocytes, improved the targeting effect by endowing NPs with the active-targeting capacity (Kokudo et al, 2003;Tseng et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of macromolecular prodrug GC-FUA based nanoparticle for hepatocellular carcinoma chemotherapy

Huang

Gao

et al. 2017

Drug Delivery

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A novel type of macromolecular prodrug delivery system is reported in this research. The N-galactosylated-chitosan-5-fluorouracil acetic acid conjugate (GC-FUA) based nanoparticle delivery system was evaluated in vitro and in vivo. Biocompatibility of GC-FUA-NPs was screened by BSA adsorption test and hemolysis activity examination in vitro. Cytotoxicity and cellular uptake study in HepG2 and A549 cells demonstrated that compared to free 5-Fu, the GC-FUA-NPs play great function in killing cancer cells for the cell endocytosis mediated by asialoglycoprotein receptor (ASGPR), which overexpresses on the cell surface. Pharmacokinetics study further illustrated that the drug-loaded nanoparticles has a much longer half-time than free 5-Fu in blood circulation in Sprague-Dawley (SD) rats. Tissue distribution was investigated in Kunming mice, and the result showed that the GC-FUA-NPs have a long circulation effect. The obtained data suggested that GC-FUA-NP is a very promising drug delivery system for efficient treatment of hepatocellular carcinoma.

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of macromolecular prodrug GC-FUA based nanoparticle for hepatocellular carcinoma chemotherapy

Huang

Gao

et al. 2017

Drug Delivery

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“…In our previous study, HAP nanoparticles with iron (Fe) and platinum (Pt) incorporation was successfully synthesized and proved that the magnetic Pt-Fe-HAP nanoparticles were highly toxic to lung cancer cells (A549) under hyperthermia and chemoagent combined therapy. 20 This finding suggests that nanosized HAP is a good candidate as chemodrug carrier.…”

Section: Introductionmentioning

confidence: 97%

Development of lattice-inserted 5-Fluorouracil-hydroxyapatite nanoparticles as a chemotherapeutic delivery system

Tseng

Chen

et al. 2015

J Biomater Appl

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Developing an effective vehicle for cancer treatment, hydroxyapatite nanoparticles were fabricated for drug delivery. When 5-Fluorouracil, a major chemoagent, is combined with hydroxyapatite nanocarriers by interclay insertion, the modified hydroxyapatite nanoparticles have superior lysosomal degradation profiles, which could be leveraged as controlled drug release. The decomposition of the hydroxyapatite nanocarriers facilitates the release of 5-Fluorouracil into the cytoplasm causing cell death. Hydroxyapatite nanoparticles with/without 5-Fluorouracil were synthesized and analyzed in this study. Their crystallization properties and chemical composition were examined by X-ray diffraction and Fourier transforms infrared spectroscopy. The 5-Fluorouracil release rate was determined by UV spectroscopy. The biocompatibility of hydroxyapatite-5-Fluorouracil extraction solution was assessed using 3T3 cells via a WST-8 assay. The effect of hydroxyapatite-5-Fluorouracil particles which directly work on the human lung adenocarcinoma (A549) cells was evaluated by a lactate dehydrogenase assay via contact cultivation. A 5-Fluorouracil-absorbed hydroxyapatite particles were also tested. Overall, hydroxyapatite-5-Fluorouracils were prepared using a co-precipitation method wherein 5-Fluorouracil was intercalated in the hydroxyapatite lattice as determined by X-ray diffraction. Energy dispersive scanning examination showed the 5-Fluorouracil content was higher in hydroxyapatite-5-Fluorouracil than in a prepared absorption formulation. With 5-Fluorouracil insertion in the lattice, the widths of the a and c axial constants of the hydroxyapatite crystal increased. The extraction solution of hydroxyapatite-5-Fluorouracil was nontoxic to 3T3 cells, in which 5-Fluorouracil was not released in a neutral phosphate buffer solution. In contrast, at a lower pH value (2.5), 5-Fluorouracil was released by the acidic decomposition of hydroxyapatite. Finally, the results of the lactate dehydrogenase assay revealed that 5-Fluorouracil-hydroxyapatite was highly toxic to A549 cells through direct culture, this phenomenon may result from lysosomal decomposition of particles causing 5-Fluorouracil releasing. The pH-responsive hydroxyapatite-5-Fluorouracil nanoparticles have the potential to be part of a selective drug-delivery system in chemotherapy for cancer treatment.

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“…Nanoparticles have been receiving persistent attentions due to their vast area of applications such as photocatalysis [1,2], biology [3,4], photonics [5], optoelectronics [6], surface-enhanced Raman scattering [7,8], and magnetism [9]. Nanoparticles, the building block for nanotechnology, are a class of materials with properties distinctly different from their bulk or molecular counterparts.…”

Section: Introductionmentioning

confidence: 99%

A green chemical method for synthesis of ZnO nanoparticles from solid-state decomposition of Schiff-bases derived from amino acid alanine complexes

Gharagozlou

Baradaran

Bayati

2015

Ceramics International

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Development of a dual-functional Pt–Fe-HAP magnetic nanoparticles application for chemo-hyperthermia treatment of cancer

Cited by 43 publications

References 35 publications

In vitro and in vivo evaluation of macromolecular prodrug GC-FUA based nanoparticle for hepatocellular carcinoma chemotherapy

In vitro and in vivo evaluation of macromolecular prodrug GC-FUA based nanoparticle for hepatocellular carcinoma chemotherapy

Development of lattice-inserted 5-Fluorouracil-hydroxyapatite nanoparticles as a chemotherapeutic delivery system

A green chemical method for synthesis of ZnO nanoparticles from solid-state decomposition of Schiff-bases derived from amino acid alanine complexes

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