Development of a high resolution MRI intracranial atherosclerosis imaging phantom

Chueh, Juyu; Marel, Kajo van der; Gounis, Matthew J.; LeMatty, Todd; Brown, Truman R.; Ansari, Sameer A.; Carroll, Timothy J.; Buck, Amanda K. W.; Zhou, Xiaohong Joe; Chatterjee, Arindam; King, R; Mao, Hui; Zheng, Shaokuan; Brooks, Olivia W.; Rappleye, Jeff W.; Swartz, Richard H.; Feldmann, Edward; Turan, Tanya N.

doi:10.1136/neurintsurg-2016-012974

Cited by 15 publications

(13 citation statements)

References 22 publications

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“…This is significant in terms of the development of medical applications for specific patients. 3D printing can be achieved either directly (where the phantom is printed) or indirectly (where the casting mold is printed and other materials are used to build the phantom) …”

Section: Introductionmentioning

confidence: 99%

“…3D printing can be achieved either directly (where the phantom is printed) or indirectly (where the casting mold is printed and other materials are used to build the phantom). 11,[13][14][15][16][17][18][19][20][21][22] This article investigates the quality of the image produced when a 3D-printed phantom is scanned by one or more of the imaging modalities introduced earlier. Image quality can be assessed either quantitatively or qualitatively.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances on the development of phantoms using 3D printing for imaging with CT, MRI, PET, SPECT, and ultrasound

2018

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Purpose: Printing technology, capable of producing three-dimensional (3D) objects, has evolved in recent years and provides potential for developing reproducible and sophisticated physical phantoms. 3D printing technology can help rapidly develop relatively low cost phantoms with appropriate complexities, which are useful in imaging or dosimetry measurements. The need for more realistic phantoms is emerging since imaging systems are now capable of acquiring multimodal and multiparametric data. This review addresses three main questions about the 3D printers currently in use, and their produced materials. The first question investigates whether the resolution of 3D printers is sufficient for existing imaging technologies. The second question explores if the materials of 3D-printed phantoms can produce realistic images representing various tissues and organs as taken by different imaging modalities such as computer tomography (CT), positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), ultrasound (US), and mammography. The emergence of multimodal imaging increases the need for phantoms that can be scanned using different imaging modalities. The third question probes the feasibility and easiness of "printing" radioactive or nonradioactive solutions during the printing process. Methods: A systematic review of medical imaging studies published after January 2013 is performed using strict inclusion criteria. The databases used were Scopus and Web of Knowledge with specific search terms. In total, 139 papers were identified; however, only 50 were classified as relevant for this paper. In this review, following an appropriate introduction and literature research strategy, all 50 articles are presented in detail. A summary of tables and example figures of the most recent advances in 3D printing for the purposes of phantoms across different imaging modalities are provided. Results: All 50 studies printed and scanned phantoms in either CT, PET, SPECT, mammography, MRI, and US-or a combination of those modalities. According to the literature, different parameters were evaluated depending on the imaging modality used. Almost all papers evaluated more than two parameters, with the most common being Hounsfield units, density, attenuation and speed of sound. Conclusions: The development of this field is rapidly evolving and becoming more refined. There is potential to reach the ultimate goal of using 3D phantoms to get feedback on imaging scanners and reconstruction algorithms more regularly. Although the development of imaging phantoms is evident, there are still some limitations to address: One of which is printing accuracy, due to the printer properties. Another limitation is the materials available to print: There are not enough materials to mimic all the tissue properties. For example, one material can mimic one property-such as the density of real tissue-but not any other property, like speed of sound or attenuation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent advances on the development of phantoms using 3D printing for imaging with CT, MRI, PET, SPECT, and ultrasound

2018

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“…Recent studies are now exploring the use of 3D printed models to replicate vessel wall pathologies such as stenosis and atherosclerotic plaques ( 26 ). Intracranial atherosclerosis disease (ICAD) can complicate mechanical thrombectomy by narrowing the vessel inner diameter (ID).…”

Section: Characteristics Of Current In-vitro Modelsmentioning

confidence: 99%

A Review of the Advancements in the in-vitro Modelling of Acute Ischemic Stroke and Its Treatment

Johnson

Dwivedi

Mirza

et al. 2022

Front. Med. Technol.

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In-vitro neurovascular models of large vessel occlusions (LVOs) causing acute ischemic stroke (AIS) are used extensively for pre-clinical testing of new treatment devices. They enable physicians and engineers to examine device performance and the response of the occlusion to further advance design solutions for current unmet clinical needs. These models also enable physicians to train on basic skills, to try out new devices and new procedural approaches, and for the stroke team to practice workflows together in the comfort of a controlled environment in a non-clinical setting. Removal of the occlusive clot in its entirety is the primary goal of the endovascular treatment of LVOs via mechanical thrombectomy (MT) and the medical treatment via thrombolysis. In MT, recanalization after just one pass is associated with better clinical outcomes than procedures that take multiple passes to achieve the same level of recanalization, commonly known as first pass effect (FPE). To achieve this, physicians and engineers are continually investigating new devices and treatment approaches. To distinguish between treatment devices in the pre-clinical setting, test models must also be optimized and expanded become more nuanced and to represent challenging patient cohorts that could be improved through new technology or better techniques. The aim of this paper is to provide a perspective review of the recent advancements in the in-vitro modeling of stroke and to outline how these models need to advance further in future. This review provides an overview of the various in-vitro models used for the modeling of AIS and compares the advantages and limitations of each. In-vitro models remain an extremely useful tool in the evaluation and design of treatment devices, and great strides have been made to improve replication of physiological conditions. However, further advancement is still required to represent the expanding indications for thrombectomy and thrombolysis, and the generation of new thrombectomy devices, to ensure that smaller treatment effects are captured.

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“…This project provided an opportunity for Chinese researchers to design a platform for multicenter investigator-initiated ICAS research utilizing the support and guidance of experienced international collaborators. The goal of the China-America MRI plaque imaging and outcome network (ChAMPION) initiative was to determine the feasibility of VW-MR sequence standardization at centers in the USA and China using a disease-specific ICAS phantom containing individual plaque components (lipid core and fibrous cap) [13].…”

Section: Introductionmentioning

confidence: 99%

Implementation of an International Vessel Wall MR Plaque Imaging Research Network: Experience with the ChAMPION Study

Chatterjee

et al. 2022

CTN

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Background and Objective: Intracranial atherosclerosis (ICAS) is one of the most common causes of stroke worldwide. High-resolution Vessel Wall MR imaging (VW-MR) is commonly used to study ICAS, but in order to accelerate advances in the field of VW-MR ICAS research, the establishment of a multicenter research network is needed. We introduce our experience in establishing a collaborative international VW-MR ICAS research network in China and North America using an innovative, disease-specific ICAS imaging phantom for standardization of VW-MR sequences at the sites. Methods: Both the Medical University of South Carolina and Peking Union Medical College functioned as Central Coordinating Centers in the network. PUMC identified research centers within China that had the potential for collaboration on VW-MR ICAS research based on networking and prior experience. All selected centers refined MRI sequences using an ICAS phantom with study principal investigators virtually present in real-time during scanning. MRI sequences were efficiently calibrated utilizing the broad expertise of all members of the research team. All centers further validated MRI sequences with human subjects. Results: We identified 11 Chinese hospitals as the potential collaborating sites for the network. Of the 11 selected sites, six sites were able to complete the required VW-MR scanning and sequence refinement using the ICAS phantom and subsequent human subjects. Conclusion: The study demonstrated the feasibility of establishing a cross-continent collaborative VW-MR research network and the use of a disease-specific phantom to facilitate convenient and efficient sequence modification for image quality standardization, which is needed for future multicenter VW-MR studies.

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Development of a high resolution MRI intracranial atherosclerosis imaging phantom

Abstract: A plaque phantom composed of a stenotic vessel wall and plaque components was successfully constructed for multicenter high resolution MRI standardization.

Cited by 15 publications

References 22 publications

Recent advances on the development of phantoms using 3D printing for imaging with CT, MRI, PET, SPECT, and ultrasound

Recent advances on the development of phantoms using 3D printing for imaging with CT, MRI, PET, SPECT, and ultrasound

A Review of the Advancements in the in-vitro Modelling of Acute Ischemic Stroke and Its Treatment

Implementation of an International Vessel Wall MR Plaque Imaging Research Network: Experience with the ChAMPION Study

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