Development of a high-throughput method for the determination of ethosuximide in human plasma by liquid chromatography mass spectrometry

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

“…Further work has shown that this pathway converges in the activation of YAP and that YAP activation is critical for the oncogenic potential of UM (Feng et al, 2014a(Feng et al, , 2014bYu et al, 2014a). The Hippo/YAP cascade is a key growth-regulating pathway in normal cellular physiology (Bhatt et al, 2010;Moroishi et al, 2015;Yu et al, 2015). Unsurprisingly, dysregulation of the Hippo pathway is seen frequently in cancer; however, its core components are rarely mutated (Martin et al, 2018;Moroishi et al, 2015).…”

Sensitive determination of ethosuximide in human fluids by electromembrane extraction coupled with high performance liquid chromatography ultraviolet spectroscopy

“…There are different analytical methods for the quantification of ETX in biological matrix. These methods include gas chromatography (GC) with flame ionization detector or mass spectrometry (MS), high-performance liquid chromatography (HPLC) with Ultra-Violet (UV) or MS, and ultra-performance liquid chromatography (UPLC) with MS. [8][9][10][11][12][13][14] However, most of the published literature deals with the determination of ETX in plasma or serum samples, while few methods have been proposed for the saliva. Among the routine process of bioanalysis, sample preparation is the foremost step in cleaning a complex biological matrix.…”