Development of a HPLC-FL method for quantitation of fluoxetine in human plasma used for therapeutic drug monitoring

Tuchila, Cristian; Baconi, Daniela Luiza; Ciobanu, Anca Marina; Niţulescu, George Mihai

doi:10.1016/j.toxlet.2016.06.1444

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2020

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“…The retention time for CAR was 6 min. It is an indication that there was no major interference from the excipients used in the solid dispersion preparations and inclusion complex (31).…”

Section: Specificitymentioning

confidence: 98%

METHOD VALIDATION AND STABILITY STUDIES OF DIFFERENTIAL ACTIVITY OF HYDROXYPROPYL-β-CYCLODEXTRIN AND HYDROPHILIC CARRIERS OF CARVEDILOL.

Boakye‐Yiadom¹,

Kesse²,

Korto³

et al. 2020

Acta Poloniae Pharmaceutica - Drug Research

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Carvedilol (CAR) is a 1-(9H-Carbazol-4yloxyl)-3-amino]-2-praponol (1) and it is basic in nature with a pKa of 7.8. CAR is both a beta and alpha receptor blocker that is used in the treatment or management of mild to moderate hypertension as well as other cardiovascular ailments namely heart failure, cardiac arrhythmias, angina pectoris, and myocardial infarction (2). Fritz Wiedemann was the first to discover the drug and it is usually in the form of a white crystalline powder (3).

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“…The retention time for CAR was 6 min. It is an indication that there was no major interference from the excipients used in the solid dispersion preparations and inclusion complex (31).…”

Section: Specificitymentioning

confidence: 98%