Development of a liquid chromatography Q Exactive high resolution mass spectrometry method by the Box-Behnken design for the investigation of sibutramine urinary metabolites

Highly resistant and sensitive colorimetric immunochromatographic assay for sibutramine (SBT) illegally adulterated into diet food based on PDA/AuNP labelling

“…Several instrument-based methodologies, such as liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS), 5 electrospray ionization mass spectrometry (ESI-MS), 5 high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), 6 and electrochemical sensors, 7 have already been implemented for the detection of SBT. These methods provide high accuracy and repeatability.…”

Analysis of 15 anti-obesity drugs in urine using thermal-assisted paper spray mass spectrometry

“…9,10 Urine is also commonly utilized in anti-obesity drug testing since it contains both the drug itself and its metabolites. [11][12][13] Additionally, the concentration of anti-obesity drugs in urine remains signicantly higher than in plasma and oral uids. 14 Despite these advantages, testing anti-obesity drugs in urine can pose challenges due to the need for pre-processing procedures to overcome matrix effects and address insufficient limits of detection (LODs) in urine samples.…”

“…9,10 Urine is also commonly utilized in anti-obesity drug testing since it contains both the drug itself and its metabolites. 11–13 Additionally, the concentration of anti-obesity drugs in urine remains significantly higher than in plasma and oral fluids. 14…”