Development of a microcomposite with single-walled carbon nanotubes and Nd2O3 for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry

Abstract

This study presents for the first time a new composite of carbon paste (CP), single-walled carbon nanotubes (SWCNTs) and Nd2O3 (NdOX). This versatile composite (NdOX-SWCNT/CPE) was applied to the oxidation of paracetamol (PCM). The newly formed surface was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The results showed greater conductivity and a higher surface area for the composite than those of the carbon paste alone. Moreover, the anodic peak currents for PCM increased from 1.6 to 3.6 µA with CPE and NdOX-SWCNT/CPE, indicating an increase of nearly 51.0% for the anodic peak current. On the other hand, the anodic peak potentials shifted from 0.67 to 0.57 V. The detection limits were 0.05 µmol/L with NdOX-SWCNT/CPE and 0.50 µmol/L with SWCNT/CPE. The relative standard deviations (RSDs) were 1.5% (n = 7). The accuracy and interference of the methods were evaluated with a urine chemistry control spiked with known quantities of PCM, uric acid, dopamine, ascorbic acid, caffeine, acetylsalicylic acid, tartrazine, sunset yellow, allure red, rutin, morin and metal ions. Finally, the novelty and usefulness of the composite were evaluated to quantify PCM in pharmaceutical dosage forms such as tablets, powders and syrups for children.

Sensitive and Profitable Electrochemical Detection of Uric Acid in the Presence of Dopamine with a Novel Carbon Paste Electrode Decorated with a Copper(II) Complex

“…The electrode modification procedure was performed as previously reported, with only the incorporated substance changed [23]. Briefly, 50.0 mg of graphite powder and 30 μL of paraffin oil were used for the unmodified electrode.…”

Simultaneous Electrochemical Determination of Paracetamol and Allura Red in Pharmaceutical Doses and Food Using a Mo(VI) Oxide‐Carbon Paste Microcomposite

“…Most studies of the detection of PCM and AR using electroanalytical techniques involve the use of carbon electrodes modified with different types of materials, most commonly carbon nanotubes for PCM [7] and graphene for RA [8]. In the case of PCM, other substances are used with carbon nanotubes to make more sensitive sensors; some of these substances are polymers such as poly (3,4-ethylenedioxythiophene) [9,10] and chitosan [11], and other materials including gold nanoparticles [12], nickel nanoparticles [13], neodymium oxide [14], lanthanum oxide [15] and cationic surfactants [16]. In these studies, PCM oxidation was observed between 0.18 and 0.45 V with a detection limit between 0.0030 and 1.69 μmol/L.…”

Development of Flexible Dispense-Printed Electrochemical Immunosensor for Aflatoxin M1 Detection in Milk

“…We measured a peak-to-peak separation value of 0.09 V for both electrodes. The deviation of the latter from its theoretical value was due to the conducting nature of the spray-coated SWCNTs [29,30].…”