Mobile devices and corresponding applications (apps) offer a unique potential for clinical work improvement. Healthcare employees already use them for a variety of clinical purposes. Even though their use might affect patients’ health and data security, they have rarely found their way into organizational knowledge management strategies. We present the current state of research regarding the prevalence, patterns, and trends of smartphone and tablet usage among physicians in clinical practice. Five electronic databases were searched for quantitative studies. The extracted data were systematically analyzed and visualized in boxplots. The results show an increasing prevalence of smartphones and medical apps in clinical practice, especially among junior physicians. Current applications can be subdivided into four categories: Communication and Organization, Documentation and Monitoring, Diagnostic and Therapeutic Decision Support, and Education. Among them, there is a large number of applications with a direct impact on physicians’ clinical actions and therefore on patients’ health and data security. In consequence, healthcare organizations should systematically integrate mobile devices and apps into their knowledge management strategies, including a modern IT infrastructure and training courses. Further studies are necessary to identify organizational and external factors that support an efficient mobile device usage during clinical practice.