Development of a more specific and accurate multiple reaction monitoring method based on GC–EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills

Jiang, Yunbin; Zhong, Ming; Gou, Yan; Peng, Wei; Zhou, Juan; Wu, Pie; Ma, Yongjun

doi:10.1016/j.jchromb.2015.01.002

Cited by 10 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Testing of precision, stability within 16 h, and repeatability indicated that the relative standard deviation (RSD, n = 6) of retention time and peak area value of 6 common peaks were <5% (Table 4, Table 5 and Table 6, Table 7, Table 8, Table 9) [12]. Hence, our method was feasible for analyzing the HPLC fingerprints of CX extracts.…”

Section: Validation Of the Hplc-fingerprint Methodsmentioning

confidence: 90%

“…Precision, stability within 16 h, and repeatability were used to assess the performance of instrument, stability of the target, and operational consistency, respectively [12].…”

Section: Validation Of Hplc Fingerprint Methodsmentioning

confidence: 99%

“…HPLC was done on a LC-2012 system (Shimadzu) and chromatographic separation was carried on a SP-120-5 C18 column (4.6 mm × 250 mm, 5 μm) operated at 25 ℃. The mobile phase comprised methanol (A) and water (B), with a linear gradient of A: 0-40 min (30-85%) [12]. The injection volume was 20 μL, and the flow rate was 1.0 mL/min.…”

Section: Hplc Conditionsmentioning

confidence: 99%

See 2 more Smart Citations

Spectrum-effect relationship between serum HPLC fingerprints and activation of blood circulation and removal of blood stasis by Chuanxiong

Ling¹,

Deng²,

Liu³

et al. 2022

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To study the active ingredients of Chuanxiong (CX) in promoting blood circulation and removing blood stasis. Methods: Blood-activating effects and serum HPLC fingerprints of CX extracts from different parts of China were studied and the spectrum-effect relationship between them was established by grey correlation analysis. Results: After treatment with CX extracted using different solvents, hemorheology indices were lower than those in the model group, and the effect of dichloromethane was better than that of other solvents (p < 0.05 or p < 0.01). There were 6 common peaks by fingerprint analysis. Peaks 1 - 5 were identified as senkyunolide I, senkyunolide H, senkyunolide A, coniferyl ferulate and ligustilide, respectively. Conclusion: Analysis of the spectrum–effect relationship indicates the contribution of the five components to the blood-activating effect of CX. The findings lend some scientific justification for using CX to remove blood stasis, and selection of quality evaluation indices for CX.

show abstract

Section: Validation Of the Hplc-fingerprint Methodsmentioning

confidence: 90%

“…Precision, stability within 16 h, and repeatability were used to assess the performance of instrument, stability of the target, and operational consistency, respectively [12].…”

Section: Validation Of Hplc Fingerprint Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Spectrum-effect relationship between serum HPLC fingerprints and activation of blood circulation and removal of blood stasis by Chuanxiong

Ling¹,

Deng²,

Liu³

et al. 2022

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…Precision, stability within 24 h, repeatability, limit of detection (LOD), limit of quantitation (LOQ) and linearity range were used to validate the content determination method for the above-named 7 constituents. Precision, stability and repeatability were used to assess instrument performance, stability of target constituent and operation consistency, respectively [11]. LOD and LOQ were deemed to be the content that came into being a signal to noise (S/N) of 3 and 10, respectively.…”

Section: Validation Of Hplc Methodsmentioning

confidence: 99%

Spectrum-effect relationships between high performance liquid chromatography fingerprint and analgesic property of Anisodus tanguticus (Maxim) Pascher (Solanaceae) roots

Jiang¹,

Zhong²,

Hu³

et al. 2017

Trop. J. Pharm Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Various analytical methods including thin layer chromatography (TLC) (Elsirafy et al 2000), enzyme-linked immunosorbent assay (ELISA) (Byer et al 2011), gas chromatography combined with mass spectrometry (GC-MS) (Hou et al 2013;Kaewsuya et al 2013;Restrepo et al 2014;Chen et al 2014;Jiang et al 2015), liquid chromatography with UV detector (LC-UV) (Abd-Alrahman 2014), and liquid chromatography with tandem mass spectrometry (LC-MS/MS) (Zhou et al 2013;Zhu et al 2013;Ma et al 2013;Coscollà et al 2014;Arias et al 2014;Shi et al 2014;Eitzer et al 2014) have been developed for analysis of different pesticides. Among them, LC-MS/MS seems more promising due to its high sensitivity and selectivity.…”

Section: Introductionmentioning

confidence: 99%

Dissipation kinetics and degradation mechanism of amicarbazone in soil revealed by a reliable LC-MS/MS method

Dong

Han

Ediage

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

A sensitive and reliable analytical method was developed for simultaneous determination of amicarbazone (AMZ) and its two major metabolites including desamino amicarbazone (DA) and isopropyl-2-hydroxy-DA-amicarbazone (Ipr-2-OH-DA-AMZ) in soil for the first time. Targeted analytes were extracted and purified using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) procedure, and then analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with a total run time of 9 min. The established approach was extensively validated by determining the linearity (R (2) ≥ 0.99), recovery (84-96 ), sensitivity (limits of quantification at 5-10 μg kg(-1)), and precision (RSDs ≤12 %). Based on the methodological advances, the subsequent dissipation kinetics and degradation mechanism of amicarbazone in soil were thoroughly investigated in an illumination incubator. As revealed, AMZ was easily degraded with the half-lives of 13.9-19.7 days in soil. Field trial results of AMZ (40 g a.i. ha(-1)) in Shanghai showed that the residues of AMZ and its metabolite Ipr-2-OH-DA-AMZ decreased from 0.505 mg kg(-1) (day 50) to 0.038 mg kg(-1) (day 365) and from 0.099 mg kg(-1) (day 50) to 0.028 mg kg(-1) (day 365), respectively, while the content of DA increased from 0.097 mg kg(-1) (day 50) to 0.245 mg kg(-1) (day 365). This study provided valuable data to understand the toxicity of AMZ and substantially promote its safe application to protect environment and human health.

show abstract

Development of a more specific and accurate multiple reaction monitoring method based on GC–EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills

Cited by 10 publications

References 19 publications

Spectrum-effect relationship between serum HPLC fingerprints and activation of blood circulation and removal of blood stasis by Chuanxiong

Spectrum-effect relationship between serum HPLC fingerprints and activation of blood circulation and removal of blood stasis by Chuanxiong

Spectrum-effect relationships between high performance liquid chromatography fingerprint and analgesic property of Anisodus tanguticus (Maxim) Pascher (Solanaceae) roots

Dissipation kinetics and degradation mechanism of amicarbazone in soil revealed by a reliable LC-MS/MS method

Contact Info

Product

Resources

About