Development of a MSFIA sample treatment system as front end of GC–MS for atenolol and propranolol determination in human plasma

Brunetto, Marı́a del Rosario; Clavijo, Sabrina; Delgado, Yelitza; Orozco, Wendy; Gallignani, Máximo; Ayala, Carlos; Cerdà, Vı́ctor

doi:10.1016/j.talanta.2014.08.056

Cited by 24 publications

(10 citation statements)

References 32 publications

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“…Moreover, this approach significantly diminishes the operational costs in comparison to commercially available apparatus for mechanization of SPE. In this sense, MSFIA was used for sample treatment before determination of the beta-blockers atenolol and propranolol in human plasma (Brunetto et al 2015). The pretreatment involved deproteinization by SPE with a restricted access material and chemical derivatization under microwave-assisted heating to produce volatile trimethylsilated derivatives, which were suitably separated by GC before MS detection.…”

Section: Manifold Designmentioning

confidence: 99%

Solid-phase extractions in flow analysis

Rocha

Batista

Melchert

2018

An. Acad. Bras. Ciênc.

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Coupling solid-phase extraction (SPE) to flow systems has promoted a synergistic development. Whereas SPE mechanization leads to improved precision and higher sample throughput, as well as diminishes systematic errors and contamination risks, analyte concentration and separation from the sample matrix provides a remarkable impact on detectability and selectivity in flow analysis. Historical aspects, main cornerstones, tips for system design, and recent applications are critically reviewed, in the context of analyte(s) separation/concentration, sample clean-up, and release of sorbed chemical species involving both packed (e.g. mini-columns, cartridges, and disks) or fluidized (e.g. beads and magnetic materials) particles. Novel (bio)sorbents, selective synthetic materials, and stationary phases for low-pressure chromatography are also discussed. Moreover, the feasibility of SPE for sample treatment before chromatographic separation, as well as the exploitation of direct measurements on the solid phase (optosensing) are emphasized.

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Section: Manifold Designmentioning

confidence: 99%

Solid-phase extractions in flow analysis

Rocha

Batista

Melchert

2018

An. Acad. Bras. Ciênc.

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“…The 4 th group will probably involve the same trends highlighted in modern analytical chemistry, with emphasis on miniaturization, green chemistry, novel strategies for microextractions, chemical speciation, bioanalysis, and analytical solutions devoted to complex samples (or complex analytical problems). As noted in recent years, [59][60][61] hyphenation of flow systems to separation techniques aiming at on-line sample pretreatment probably will remain a fertile research field. Some recent examples will be discussed next.…”

Section: Looking Forward: Research Perspectives On Flow Analysismentioning

confidence: 99%

“…A recent example of the former is exploitation of a multisyringe flow system for sample treatment before determination of the beta-blockers atenolol and propranolol in human plasma. 60 The in-line sample treatment involved deproteinization by SPE with a restricted access material and chemical derivatization under microwave-assisted heating to yield trimethylsilated derivatives. A sampling rate of 7 h -1 was achieved by performing sample treatment and separation by gas chromatography simultaneously.…”

Section: Looking Forward: Research Perspectives On Flow Analysismentioning

confidence: 99%

Flow Analysis: Looking Back and Forward

Rocha¹

2018

J. Braz. Chem. Soc.

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Flow analysis changed significantly the way of performing chemical analysis by (i) mechanization of analytical procedures in a continuous flowing stream with minimal sample intercontamination; (ii) analytical measurements without attaining chemical equilibria, thus increasing the applicability of kinetic methods and allowing the exploitation of non-quantitative processes; (iii) exploitation of concentration gradients and (iv) use of unstable reagents or measurement of unstable products. Flow-based procedures are generally characterized by high sample throughput, improved precision, minimized waste generation, and often better selectivity. The performance of detection systems is usually improved because of the in-line sample conditioning and measurements under reproductive dynamic conditions and timing. However, after achieving several innovations, perspectives for further developments have been questioned mainly because of the recent decrease in the number of publications on flow analysis. The aim of this review is then to discuss the impact of flow-based methods on chemical analysis, emphasizing recent applications and developments, including miniaturization, bioanalysis, microextractions, green analytical chemistry and synergic hyphenation with other techniques and processes. The author's personal view about research perspectives in the field is also presented.

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“…These methods include: spectrophotometry [5][6][7][8] , NMR spectroscopy 9 , fluorimetry 10 , potentiometry 11 , GC [12][13] , HPLC [14][15][16][17][18] and capillary electrophoresis [19][20][21] . Despite the precision and accuracy of chromatographic and capillary electrophoresis methods, these are time-consuming and expensive due to high analytical cost, limiting the operation of these instruments to highly qualified laboratory persons.…”

Section: Fig 1: Chemical Structures Of Drugs: a Atenolol B Esmololmentioning

confidence: 99%

Untitled

2017

IJPSR

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Atenolol and esmolol drugs belonging to a β-blocker group are frequently used for the treatment of cardiovascular diseases. These drugs are also charged as water pollutants. A new simple and rapid spectrophotometric method has been developed for their determination in pharmaceutical formulations and in spiked water samples. The proposed method is based on the derivatization of the amino function present in these drugs to the corresponding yellow copper (I) drug dithiocarbamate derivative through reaction with carbon disulphide, pyridine and copper (I) perchlorate in aqueous acetonitrile. The analysis is accomplished for their determination in pharmaceutical formulations by measuring absorbance at 425 nm for atenolol and 420 nm for esmolol. For the determination of these drugs in spiked water samples, the coloured complex is extracted into chloroform and the absorbance of the chloroform extracts is measured at 415 nm and 410 nm for atenolol and esmolol respectively. Linear correlation is obtained in the range 1.00 -22.00 and 1.50 -25.00 µg mL -1 with detection limits of 0.10 and 0.15µg mL -1 for atenolol and esmolol respectively. The proposed methods show good recoveries of atenolol and esmolol from pharmaceutical formulations and spiked water samples and are in the ranges from 99.00 -100.40% and 98.20 -100.80% respectively. The 1:1 stoichiometry of the colour reaction between drug as dithiocarbamate derivative and copper (I) perchlorate has been established by photometric titrations. The latter also provides an alternative method for the determination of above drugs in pharmaceutical formulations.

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Development of a MSFIA sample treatment system as front end of GC–MS for atenolol and propranolol determination in human plasma

Cited by 24 publications

References 32 publications

Solid-phase extractions in flow analysis

Solid-phase extractions in flow analysis

Flow Analysis: Looking Back and Forward

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