Development of a multi-analyte CMOS sensor for point-of-care testing

Lock-In Pixel CMOS Image Sensor for Time-Resolved Fluorescence Readout of Lateral-Flow Assays

“…Ref. [17] Eu With regard to the aforementioned explanations, the LIP CIS-based TRF reader presented in this work shows the best performance in terms of the lowest LoD and highest DDR compared to state-of-the-art CMOS biochip contact imaging and contact sensing immunoassay approaches [18]- [20] as well as to commercially available Eu particle based TRF-LFA approaches [13], to our previous work [14] and to colorimetric LFA readers using gold NP [21].…”

“…(1) Prostate specific antigen, (2) Horseradish peroxidase, (3) Tetramethylbenzidine, (4) Values for customized DDR for CRP Ab02 assay according to Fig. 4 (f) and Section 3.5 in [18], (5) Estimated value for customized DDR for CRP Ab02 assay according to Fig. 4 (f) in [18], (6) Estimated value for HIV antibody detection from Fig.…”

“…4 (f) and Section 3.5 in [18], (5) Estimated value for customized DDR for CRP Ab02 assay according to Fig. 4 (f) in [18], (6) Estimated value for HIV antibody detection from Fig. 3 (c) in [19], (7) Procalcitonin, (8) Medisensor aQcare™ TRF system, (9) Calculated average intra-assay precision.…”

CMOS biosensors for in vitro diagnosis – transducing mechanisms and applications

“…Klapproth et al demonstrated a multianalyte CMOS sensor to measure multiple sandwich-ELISA reactions performed on the CMOS chip. 63 The chemiluminescence is recorded by the on-chip photodetector working in the reverse-bias region. This allows parallel detection of different biological targets, such as immunoglobulin E and myoglobin, and shows comparable results to the clinical protocols.…”