Development of a multicommuted flow-through optosensor for the determination of a ternary pharmaceutical mixture

Gilbert-López, Bienvenida; Llorent‐Martínez, Eulogio J.; Ortega‐Barrales, P.; Molina‐Díaz, Antonio

doi:10.1016/j.jpba.2006.08.003

Cited by 19 publications

(7 citation statements)

References 13 publications

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“…Most of these systems have dealt with the determination of two analytes; however, some systems have been designed in order to quantify three analytes (18,21,55). Different approaches can be used to fulfill this purpose:…”

Section: Classification Of Fto In Terms Of Number Of Analytesmentioning

confidence: 99%

Contribution to Automation for Determination of Drugs Based on Flow-Through Optosensors

Llorent‐Martínez

Ortega‐Barrales

Córdova

et al. 2011

Applied Spectroscopy Reviews

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The contribution of solid-phase spectroscopy (SPS) from its first conception (batch mode) to developments based on implementing SPS with flow analysis methodologies, flow-through optosensors (FTOs), is discussed. This article reviews the technical status of these sensors and addresses works of different flow technologies for the detection of drugs in pharmaceutical and clinical samples. In order to give readers insight into the features and the potential of FTO, relevant examples of strategies and typesof configuration are studied. The reports cited show the characteristics of these systems, including high sensitivity and selectivity, easy automation, less amount of reagent used, and low cost of the equipment. Finally, the advantages and disadvantages of the different flow methodologies described as well as a comparison with chromatographic techniques are critically highlighted.

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Section: Classification Of Fto In Terms Of Number Of Analytesmentioning

confidence: 99%

Contribution to Automation for Determination of Drugs Based on Flow-Through Optosensors

Llorent‐Martínez

Ortega‐Barrales

Córdova

et al. 2011

Applied Spectroscopy Reviews

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“…In the latter case, the separation of the analytes can be made using a mini-column filled with the same solid support used in the flow-through cell [30,31] or in the same flow-through cell [32,33]. When the retention/desorption kinetic of the analytes on the solid support is very different, the separation can be performed by just placing an extra amount of microbeads in the flow-though cell.…”

Section: Multicommutated Flow Analysismentioning

confidence: 99%

“…This system has been used for the spectrophotometric determination of pirydoxine/piroxicam [34] and salicylamide/caffeine [31] in pharmaceutical preparations, as long as the fluorimetric quantita- tion of furosemide and triamterene [35] in pharmaceuticals and biological fluids. A triparameter optosensor has been also developed for determining salicylamide, caffeine and propyphenazone in pharmaceuticals; the separation was also performed using a mini-column, but two eluting solutions were required [30].…”

Section: Multicommutated Flow Analysismentioning

confidence: 99%

Multicommutation in Flow Systems: A Useful Tool for Pharmaceutical and Clinical Analysis

Llorent‐Martínez¹,

Barrales²,

Córdova³

et al. 2010

CPA

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Multicommutation is a methodology of increasing use for the development of chemical analysis systems. Specifically, it refers to continuous-flow configurations designed with computer-controlled commutators. The flow system, based on the implementation of solenoid valves in Flow Injection Analysis (FIA), is called Multicommutated Flow System (MCFIA). These flow systems can be easily re-configured by just changing the procedure with the software, resulting in increased versatility, potential for automation and minimization of both reagent consumption and waste generation. The use of solenoid pumps for propelling the solutions has been recently introduced and is known as Multipumping Flow Systems (MPFS). Finally, Multisyringe Flow Injection Analysis (MSFIA) has been developed implementing multicommutation principles in a modified Sequential Injection Analysis (SIA) system. This review covers a brief description about the fundamentals of the above mentioned methodologies as well as their application to pharmaceutical and clinical analysis. Several examples are given and some particular aspects are highlighted, such as the differences between measuring the analytical signal in solution or on a solid support (flow-through optosensor), a detailed classification of the reported methods in terms of the flow technique employed, or the novelty of each published method.

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“…The selected applications in Tables 1-7 do not reflect the whole available methodology, as the number of applications is very Simultaneous determination [191] Tartaric acid Wine UV-vis 0.50-10.0 g L −1 28…”

Section: Applicationsmentioning

confidence: 99%

Multi-commutation in flow analysis: Recent developments and applications

Feres¹,

Fortes²,

Zagatto³

et al. 2008

Analytica Chimica Acta

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Development of a multicommuted flow-through optosensor for the determination of a ternary pharmaceutical mixture

Cited by 19 publications

References 13 publications

Contribution to Automation for Determination of Drugs Based on Flow-Through Optosensors

Contribution to Automation for Determination of Drugs Based on Flow-Through Optosensors

Multicommutation in Flow Systems: A Useful Tool for Pharmaceutical and Clinical Analysis

Multi-commutation in flow analysis: Recent developments and applications

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