Development of a multilayered polymeric DNA biosensor using radio frequency technology with gold and magnetic nanoparticles

Yang, Cheng; Kuo, Long-Sheng; Chen, Ping‐Hei; Yang, Chii Rong; Tsai, Zuo Min

doi:10.1016/j.bios.2011.10.044

Cited by 18 publications

(9 citation statements)

References 32 publications

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“…In order to enhance the sensitivity of biomolecule detection, various nanomaterials have been applied to develop RF biosensors. A polymeric RF biosensor with the AuNPs and magnetic nanoparticles (MNPs) was developed to enhance the detection sensitivity of DNA [ 59 ]. Previous studies have shown that the nuclear magnetic resonance-based RF biosensor has an ability to detect various biomolecules such as avidin, human chorionic gonadotropin, and human bladder cancer cells [ 60 ].…”

Section: Microwave Breast Imaging Methods and Measurement Systemsmentioning

confidence: 99%

Early Diagnosis of Breast Cancer

Wang

2017

Sensors

381

220

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Early-stage cancer detection could reduce breast cancer death rates significantly in the long-term. The most critical point for best prognosis is to identify early-stage cancer cells. Investigators have studied many breast diagnostic approaches, including mammography, magnetic resonance imaging, ultrasound, computerized tomography, positron emission tomography and biopsy. However, these techniques have some limitations such as being expensive, time consuming and not suitable for young women. Developing a high-sensitive and rapid early-stage breast cancer diagnostic method is urgent. In recent years, investigators have paid their attention in the development of biosensors to detect breast cancer using different biomarkers. Apart from biosensors and biomarkers, microwave imaging techniques have also been intensely studied as a promising diagnostic tool for rapid and cost-effective early-stage breast cancer detection. This paper aims to provide an overview on recent important achievements in breast screening methods (particularly on microwave imaging) and breast biomarkers along with biosensors for rapidly diagnosing breast cancer.

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Section: Microwave Breast Imaging Methods and Measurement Systemsmentioning

confidence: 99%

Early Diagnosis of Breast Cancer

Wang

2017

Sensors

381

220

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“…The two kinds of nanoparticles were modified by glucose oxidase coating on poly‐allylamine hydrochloride, which finally deposited on a planar interdigitated electrode . Gold and MNPs also have been applied to develop a multilayered polymeric DNA sensor by the radio frequency technology . Moreover, Chauhan et al described a method of preparing an amperometric biosensor to determined glutathione .…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

“…116 Gold and MNPs also have been applied to develop a multilayered polymeric DNA sensor by the radio frequency technology. 117 Moreover, Chauhan et al described a method of preparing an amperometric biosensor to determined glutathione. 118 They immobilized a glutathione oxidase onto the surface of gold coated MNPs to modify Pt electrode, then, they used chitosan introduce amino groups onto the surface of MNPs.…”

Section: In Biosensorsmentioning

confidence: 99%

Current investigations into magnetic nanoparticles for biomedical applications

Jiang

Aifantis

et al. 2016

J Biomedical Materials Res

281

166

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It is generally recognized that nanoparticles possess unique physicochemical properties that are largely different from those of conventional materials, specifically the electromagnetic properties of magnetic nanoparticles (MNPs). These properties have attracted many researchers to launch investigations into their potential biomedical applications, which have been reviewed in this article. First, common types of MNPs were briefly introduced. Then, the biomedical applications of MNPs were reviewed in seven parts: magnetic resonance imaging (MRI), cancer therapy, the delivery of drugs and genes, bone and dental repair, tissue engineering, biosensors, and in other aspects, which indicated that MNPs possess great potentials for many kinds of biomedical applications due to their unique properties. Although lots of achievements have been obtained, there is still a lot of work to do. New synthesis techniques and methods are still needed to develop the MNPs with satisfactory biocompatibility. More effective methods need to be exploited to prepare MNPs-based composites with fine microstructures and high biomedical performances. Other promising research points include the development of more appropriate techniques of experiments both in vitro and in vivo to detect and analyze the biocompatibility and cytotoxicity of MNPs and understand the possible influencing mechanism of the two properties. More comprehensive investigations into the diagnostic and therapeutic applications of composites containing MNPs with "core-shell" structure and deeper understanding and further study into the properties of MNPs to reveal their new biomedical applications, are also described in the conclusion and perspectives part.

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“…Fe 3 O 4 magnetic nanoparticles (Fe 3 O 4 -MNPs) is the only nanomaterial that has been approved for clinical applications because of their relative safety, unique magnetic responsiveness, and their simple and controllable preparation 4 5 . Up until now, Fe 3 O 4 -MNPs have been widely explored in the clinic fields, such as magnetic resonance imaging (MRI) contrast agents, biosensors, tumor-targeting photothermal therapy, and regenerative medicine 6 7 8 9 . For example, commercially available Fe 3 O 4 -MNPs (e.g.…”

mentioning

confidence: 99%

Eryptosis Indices as a Novel Predictive Parameter for Biocompatibility of Fe3O4 Magnetic Nanoparticles on Erythrocytes

Ran

Xiang

Liu

et al. 2015

Sci Rep

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Fe3O4 magnetic nanoparticles (Fe3O4-MNPs) have been widely used in clinical diagnosis. Hemocompatibility of the nanoparticles is usually evaluated by hemolysis. However, hemolysis assessment does not measure the dysfunctional erythrocytes with pathological changes on the unbroken cellular membrane. The aim of this study is to evaluate the use of suicidal death of erythrocytes (i.e. eryptosis indices) as a novel predictive and prognostic parameter, and to determine the impact of Fe3O4-MNPs on cellular membrane structure and the rheology properties of blood in circulation. Our results showed that phosphatidylserine externalization assessment was significantly more sensitive than classical hemolysis testing in evaluating hemocompatibility. Although no remarkable changes of histopathology, hematology and serum biochemistry indices were observed in vivo, Fe3O4-MNPs significantly affected hemorheology indices including erythrocyte deformation index, erythrocyte rigidity index, red blood cell aggregation index, and erythrocyte electrophoresis time, which are related to the mechanical properties of the erythrocytes. Oxidative stress induced calcium influx played a critical role in the eryptotic activity of Fe3O4-MNPs. This study demonstrated that Fe3O4-MNPs cause eryptosis and changes in flow properties of blood, suggesting that phosphatidylserine externalization can serve as a predictive parameter for hemocompatibility assay.

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Development of a multilayered polymeric DNA biosensor using radio frequency technology with gold and magnetic nanoparticles

Cited by 18 publications

References 32 publications

Early Diagnosis of Breast Cancer

Early Diagnosis of Breast Cancer

Current investigations into magnetic nanoparticles for biomedical applications

Eryptosis Indices as a Novel Predictive Parameter for Biocompatibility of Fe3O4 Magnetic Nanoparticles on Erythrocytes

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