Development of a New Class of AIEgens

More, Vishal G.; Jadhav, Ratan W.; Kobaisi, Mohammad Al; Jones, Lathe A.; Bhosale, Sheshanath V.

doi:10.1002/9781119643098.ch29

Cited by 1 publication

(2 citation statements)

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“…[1] In contrast, AIE molecules exhibit the anti-ACQ effect, emitting intense fluorescence when aggregating. [2,3] Due to the attractive features of the AIE phenomenon, a variety of AIE fluorophores have been synthesized and investigated for their potential applications in the field of biosensing as well as chemosensing. The AIE molecules have been reported as a bio-probe for the detection of protein, DNA, heparin, ATP, G-quadruplex formation, etc.. [4][5][6][7][8][9][10][11] Research-ers have developed several methods for selective and sensitive detection of proteins in aqueous media, in which most of these methods displayed changes in their colorimetric properties due to the chemical reactions or physical interactions with proteins.…”

Section: Introductionmentioning

confidence: 99%

“…The ACQ fluorophores, when aggregates in polar solvents, show fluorescence quenching [1] . In contrast, AIE molecules exhibit the anti‐ACQ effect, emitting intense fluorescence when aggregating [2,3] . Due to the attractive features of the AIE phenomenon, a variety of AIE fluorophores have been synthesized and investigated for their potential applications in the field of biosensing as well as chemosensing.…”

Section: Introductionmentioning

confidence: 99%

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AIE‐Active ‘Turn‐On’ Sensors for Highly Selective Detection of Bovine Serum Albumin**

Gawade,

Jadhav,

Singh

et al. 2023

ChemistrySelect

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Tetraphenylethylene (TPE)‐based, two molecular ‘Turn‐On’ probes i. e. 4,4′,4′′,4′′′‐(ethene‐1,1,2,2‐tetrayl)tetraphenol (tetrahydroxy‐TPE, coded as: TPE‐1) 4,4′,4′′,4′′′‐(ethene‐1,1,2,2‐tetrayl)tetraaniline and tetraamino‐TPE, coded as: TPE‐2) have been successfully reported for the selective detection of bovine serum albumin (BSA) over its other biological competitors. The BSA sensing has been investigated using UV‐Vis absorption and fluorescence emission spectroscopy, where the fluorescence of probes tetrahydroxy‐TPE and tetra‐amino‐TPE was significantly enhanced in the presence of BSA. The BSA sensing was also characterized by visual eye detection, where a significant color change of probe tetrahydroxy‐TPE and tetra‐amino‐TPE was observed with BSA. The detection limit for BSA was calculated to be 0.2 nM and 1.41 nM for using probes tetrahydroxy‐TPE and tetra‐amino‐TPE, respectively. The binding constant was observed to be1.8×103 M and 1.4×103 M for probes tetrahydroxy‐TPE and tetra‐amino‐TPE, respectively. A molecular docking study is also performed to investigate the detailed interactions between probes tetrahydroxy‐TPE and tetra‐amino‐TPE with BSA. The lowest binding energy conformation for probes tetrahydroxy‐TPE and tetra‐amino‐TPE was found at −8.1 kcal/mol and −8.2 kcal/mol, respectively.

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