Development of a New Drug Carrier Made from Alginate

Rajaonarivony, M.; Vauthier, Christine; Couarraze, G.; Puisieux, F.; Couvreur, Patrick

doi:10.1002/jps.2600820909

Cited by 368 publications

(197 citation statements)

References 17 publications

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“…22 Alginate is widely used in the food industry as a thickening agent and stabilizer and in the pharmaceutical industry as drug carriers. [24][25][26] NOM was found to strongly interact with NPs in suspension through electrostatic forces and steric interactions, thus modifying significantly their transport and bioavailability. Once the surface is coated with natural polymers or humic substances, the NPs are stabilized against aggregation except in the presence of divalent salts which are found to promote aggregation via bridging mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Effect of natural organic matter on the disagglomeration of manufactured TiO2 nanoparticles

Loosli

Coustumer

Stoll

2014

Environ. Sci.: Nano

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One major concern in the fate of nanomaterials in aquatic systems is the lack of data on nanomaterial transformations under relevant environmental conditions. The disagglomeration of aggregates composed of manufactured anatase titanium dioxide nanoparticles is investigated here in the presence of alginate and Suwannee River humic acids at varying concentrations using dynamic light scattering and electrophoretic measurements. Stability of TiO 2 nanoparticle agglomerates at typical environmental concentrations of natural organic matter is discussed at a pH value corresponding to the point of zero charge of TiO 2 nanoparticles. In this scenario, the surface charge of TiO 2 is neutralized, allowing the nanoparticles to form large agglomerates. Alginate and Suwannee River humic acids exhibit a negative structural charge under this pH condition and adsorption of both natural polyelectrolytes on the surface of nanoparticle agglomerates leads to disagglomeration and significant redispersion of TiO 2 nanoparticles into fragments. Results indicate that both electrostatic forces and steric interactions play key roles during the disagglomeration process and that the physicochemical properties of natural organic matter are found to influence the kinetics and importance of fragmentation in the disagglomeration process. Most importantly, our data indicate that the presence of natural organic matter at typical environmental concentrations induces significant disagglomeration of large submicron nanoparticle agglomerates. Such a result constitutes an important outcome with regards to the risk associated with manufactured nanoparticles by including the possible transformations of the micron size range structures they can form. Nano impactOne of the main problems in the ecological risk assessment of nanomaterials is the lack of important information on their environmental (bio)physicochemical transformations. The disagglomeration of manufactured titanium dioxide nanoparticles is investigated here in the presence of alginate and Suwannee River humic acids at realistic environmental concentrations. Under such concentration conditions, the adsorption of these compounds is found to induce disagglomeration and significant redispersion of TiO 2 nanoparticles into fragments. Such a result constitutes an important outcome with regards to the risk associated with manufactured nanoparticles by considering one important life-cycle transformation of micron size range structures composed of nanoparticles in aquatic systems.

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Section: Introductionmentioning

confidence: 99%

Effect of natural organic matter on the disagglomeration of manufactured TiO2 nanoparticles

Loosli

Coustumer

Stoll

2014

Environ. Sci.: Nano

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“…In the CaA complex, the calcium ions interact mainly with oligopolyguluronic sequences of the alginate, producing an 'egg-box' structure (Grant et al, 1973). As alginates are negatively charged polymers, they form preferentially at the level of the mannuronic sequences complexes with cationic compounds (chlorpheniramine, doxorubicin, propranolol) (Stockwell et al, 1986;Segi et al, 1989;Rajaonarivony et al, 1993), as well as with polycations (polysaccharides, polypeptides, or synthetic polymers) (Bystricky et al, 1990;Thu et al, 1996;Gombotz & Wee, 1998;Coppi et al, 2004). An alginate with high mannuronic content was used in a previous work to design a biodegradable intra-operative system releasing gentamicin for bone infection treatment.…”

Section: Introductionmentioning

confidence: 99%

Microparticulate polyelectrolyte complexes for gentamicin transport across intestinal epithelia

et al. 2010

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“…Introduction of the cationic polymer (chitosan, poly-L-arginine or poly-L-lysine) can adjust the size of the particles formed. For example, 250-850 nm (depending on the alginate concentration) particles were synthesized as drug carriers; these particles are formed in solution by adding sodium alginate, calcium chloride and then poly-L-lysine [43]. The particle size can also be controlled by the volume of "nanoreactors" (micelles); reverse micelles were successfully used to synthesize nanocarriers (from alginate and calcium salts) with an average size of about 80 nm in diameter exhibiting a high degree of endocytosis by NIH 3T3 cells [44].…”

Section: The Hypothesis Assessment and Reviewmentioning

confidence: 99%

Layer-by-layer capsules as smart delivery systems of CeO2 nanoparticle-based theranostic agents

Popova¹,

Попов²,

Shcherbakov³

et al. 2017

Nanosystems: Phys. Chem. Math.

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Modern methods of cancer treatment include chemotherapy and radiotherapy, but they are often characterized by low efficacy and high toxicity. The effectiveness of cancer therapy is often limited by a lack of effective systems for drug delivery to the tumor site. Cerium oxide nanoparticles are able to act as radioprotectors and as radiosensitizers exhibiting selective toxicity in the tumor microenvironment, providing for their tremendous potential in treating cancer. However, methods for controlled delivery of CeO 2 nanoparticles to the tumor have not been investigated nor described yet. In this article, we consider different approaches to the development of new ceria nanoparticle-based theranostic agents. Modification of polyelectrolyte microcapsules with nano-ceria appears to be the most promising method. Our design proposals are based on the synergistic pharmacological action of ceria-based nanomaterials and anticancer pharmaceuticals with the ability to control and visualize their sites of localization.

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Development of a New Drug Carrier Made from Alginate

Cited by 368 publications

References 17 publications

Effect of natural organic matter on the disagglomeration of manufactured TiO2 nanoparticles

Effect of natural organic matter on the disagglomeration of manufactured TiO2 nanoparticles

Microparticulate polyelectrolyte complexes for gentamicin transport across intestinal epithelia

Layer-by-layer capsules as smart delivery systems of CeO2 nanoparticle-based theranostic agents

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