Development of a New Magnetometer for Sentinel Lymph Node Mapping Designed for Video-Assisted Thoracic Surgery in Non–Small Cell Lung Cancer

Imai, Kazuhiro; Kawaharada, Yasushi; Ogawa, Jun–ichi; Saito, Hajime; Kudo, Satoshi; Takashima, Shinogu; Saito, Yasutoshi; Atari, Maiko; Ito, Aki; Terata, Kaori; Yoshino, Kei; Sato, Yusuke; Motoyama, Satoru; Minamiya, Yoshihiro

doi:10.1177/1553350615585421

Cited by 6 publications

(4 citation statements)

References 26 publications

(29 reference statements)

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“…Meng et al (63) suggested that if MRI could accurately diagnose axillary lymph node metastases in early stage breast cancer, the most cost-effective strategy was to replace sentinel lymph node biopsy with axillary MRI. Detection of sentinel lymph nodes with SPIO can be done by a simple hand-hold probe ( Figure 3) (64)(65)(66)(67). A number of studies with the combination of Sienna plus ® and SentiMag ® (Endomagentics Ltd) have been reported.…”

Section: Sentinel Lymph Node Detection With Spio (Interstitial Mr Lymmentioning

confidence: 99%

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Wáng

Idée

2017

Quant. Imaging Med. Surg.

199

116

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Section: Sentinel Lymph Node Detection With Spio (Interstitial Mr Lymmentioning

confidence: 99%

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Wáng

Idée

2017

Quant. Imaging Med. Surg.

199

116

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“…However, comparing with the standard dual technique, the predefined non-inferiority margin was not reached in the MELAMAG Trial [23]. Furthermore, initial data on the use of magnetometer-guided SLN detection in lung cancer and colorectal cancer were reported [30,31].…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Magnetometer-Guided Sentinel Lymphadenectomy after Intraprostatic Injection of Superparamagnetic Iron Oxide Nanoparticles in Prostate Cancer: The SentiMag Pro II Study

Winter

Engels

Goos

et al. 2019

Cancers

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Radioisotope-guided sentinel lymph node dissection (sLND) has shown high diagnostic reliability in prostate (PCa) and other cancers. To overcome the limitations of the radioactive tracers, magnetometer-guided sLND using superparamagnetic iron oxide nanoparticles (SPIONs) has been successfully used in PCa. This prospective study (SentiMag Pro II, DRKS00007671) determined the diagnostic accuracy of magnetometer-guided sLND in intermediate-and high-risk PCa. Fifty intermediate-or high-risk PCa patients (prostate-specific antigen (PSA) ≥ 10 ng/mL and/or Gleason score ≥ 7; median PSA 10.8 ng/mL, IQR 7.4-19.2 ng/mL) were enrolled. After the intraprostatic SPIONs injection a day earlier, patients underwent magnetometer-guided sLND and extended lymph node dissection (eLND, followed by radical prostatectomy. SLNs were detected in in vivo and in ex vivo samples. Diagnostic accuracy of sLND was assessed using eLND as the reference. SLNs were detected in all patients (detection rate 100%), with 447 sentinel lymph nodes SLNs (median 9, IQR 6-12) being identified and 966 LNs (median 18, IQR 15-23) being removed. Thirty-six percent (18/50) of patients had LN metastases (median 2, IQR 1-3). Magnetometer-guided sLND had 100% sensitivity, 97.0% specificity, 94.4% positive predictive value, 100% negative predictive value, 0.0% false negative rate, and 3.0% additional diagnostic value (LN metastases only in SLNs outside the eLND template). In vivo, one positive SLN/LN-positive patient was missed, resulting in a sensitivity of 94.4%. In conclusion, this new magnetic sentinel procedure has high accuracy for nodal staging in intermediate-and high-risk PCa. The reliability of intraoperative SLN detection using this magnetometer system requires verification in further multicentric studies.

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“…In a previous study, it was shown that SPIONs reach the axillary lymph nodes within minutes after injection into the breast [ 60 ]. To detect SPIONs, several magnetometers have been developed [ 43 , 56 , 64 ].…”

Section: Intraoperative Diagnosis During Surgerymentioning

confidence: 99%

Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology

Onishi

Mihara

Matsuda

et al. 2022

Cancers

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Screening, monitoring, and diagnosis are critical in oncology treatment. However, there are limitations with the current clinical methods, notably the time, cost, and special facilities required for radioisotope-based methods. An alternative approach, which uses magnetic beads, offers faster analyses with safer materials over a wide range of oncological applications. Magnetic beads have been used to detect extracellular vesicles (EVs) in the serum of pancreatic cancer patients with statistically different EV levels in preoperative, postoperative, and negative control samples. By incorporating fluorescence, magnetic beads have been used to quantitatively measure prostate-specific antigen (PSA), a prostate cancer biomarker, which is sensitive enough even at levels found in healthy patients. Immunostaining has also been incorporated with magnetic beads and compared with conventional immunohistochemical methods to detect lesions; the results suggest that immunostained magnetic beads could be used for pathological diagnosis during surgery. Furthermore, magnetic nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPIONs), can detect sentinel lymph nodes in breast cancer in a clinical setting, as well as those in gallbladder cancer in animal models, in a surgery-applicable timeframe. Ultimately, recent research into the applications of magnetic beads in oncology suggests that the screening, monitoring, and diagnosis of cancers could be improved and made more accessible through the adoption of this technology.

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Development of a New Magnetometer for Sentinel Lymph Node Mapping Designed for Video-Assisted Thoracic Surgery in Non–Small Cell Lung Cancer

Abstract: The new VATS-compatible magnetometer appears to have substantial advantages over techniques using a radioisotope and our earlier magnetometer, as it can be inserted through the small VATS port site.

Cited by 6 publications

References 26 publications

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Accuracy of Magnetometer-Guided Sentinel Lymphadenectomy after Intraprostatic Injection of Superparamagnetic Iron Oxide Nanoparticles in Prostate Cancer: The SentiMag Pro II Study

Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology

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