Development of a Pharmacophore Model for a Novel Hematoregulatory Peptide

Abstract

and other references cited in this review. (2) Bhatnagar, P. K.; Agner, E.; Alberts, D.; Arbo, B. A.; Callahan, J.; Cuthbertson, A.; Engelsen, S. J.; Hartmann, M.; Heerding, D.; Hiebl, J.; Huffman, W. F.; Hysben, M.; Fjerdingstad, H.; King, A. K.; Kwon, C.; Kremminger, P.; LoCastro, S.; Løvhaug, D.; Pelus, L. M.; Petteway, S.; Takata, J.

Polymorphism, Phase Transitions, and Thermal Stability of l-Pyroglutamic Acid

“…P is the chain-terminator or N-terminal residue of a number of biologically significant proteins and peptides. [1][2][3] It occurs naturally in fruits, some plant foods, dairy, and fermented products such as soy sauce and can be produced by thermal dehydration and cyclization of Glu. 4,5 In neurology, the brain-boosting effects of P were discovered in 1984.…”

“…Both P and Glu are chiral molecules, with the chiral centers marked by an asterisk in Figure . P is the chain-terminator or N-terminal residue of a number of biologically significant proteins and peptides. − It occurs naturally in fruits, some plant foods, dairy, and fermented products such as soy sauce and can be produced by thermal dehydration and cyclization of Glu. , In neurology, the brain-boosting effects of P were discovered in 1984 . It plays an important role in the preservation and activity of the key neurotransmitters acetylcholine, gamma-aminobutyric acid (GABA) and Glu; − it readily passes the blood−brain barrier to stimulate cognitive-enhancing function in rats and reduce age-associated memory decline in humans .…”

Enantioselective Synthesis of Diamino Dicarboxylic Acids

“…Recently compound 6 15 (SK&F 107647, Scheme ), a nonapeptide with hematoregulatory activity, has demonstrated significant protection in animal models of bacterial, fungal, and viral diseases and bone marrow transplantation . Compound 6 is the dicarba analogue of the disulfide 7 , which is the dimer of the hemoregulatory peptide, HP5b (Pyr-Glu-Asp-Cys-Lys) isolated by Laerum and Paukovits from mature human leukocytes …”

“…transplantation. 16 Compound 6 is the dicarba analogue of the disulfide 7, 17 which is the dimer of the hemoregulatory peptide, HP5b (Pyr-Glu-Asp-Cys-Lys) isolated by Laerum and Paukovits from mature human leukocytes. 18 The identification of these low molecular weight compounds, 6 and 7, which display high biological activity, represented a breakthrough in the field of hematopoiesis, which is dominated by proteins, e.g.…”