Development of a prediction model of severe reaction in boiled egg challenges

Sugiura, Shiro; Matsui, Teruaki; Nakagawa, Tomoko; Sasaki, Kemal; Nakata, Jun; Kando, Naoyuki; Ito, Komei

doi:10.1016/j.alit.2016.01.005

Cited by 34 publications

(22 citation statements)

References 30 publications

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“…Similar to the previous analysis 3,4 the specific IgE titer has the strongest impact on the severity. Given that WH-sIgE showed a stronger correlation with TS/Pro than ω5G-sIgE ( Figure S1), we selected WH-sIgE as a predictive factor.…”

Section: Allergysupporting

confidence: 81%

“…The purpose of oral food challenges (OFCs) has gradually transformed from a definitive diagnosis of a food allergy to determining the threshold dose of food allergens at the beginning of oral immunotherapy (OIT) or the amount of minimal intake, which has recently come to be considered a better method of managing IgE-mediated food allergy 1,2 However, OFCs in patients with severe food allergies, defined as low-threshold and severe reactions, carry a risk of triggering anaphylaxis. To predict such severe reactions before OFC, we previously reported prediction models consisting of multiple factors for hen's egg 3 and cow's milk 4…”

Section: Development Of a Prediction Model For Severe Wheat Allergymentioning

confidence: 99%

“…To predict such severe reactions before OFC, we previously reported prediction models consisting of multiple factors for hen's egg 3 and cow's milk 4 allergy.…”

Section: Development Of a Prediction Model For Severe Wheat Allergymentioning

confidence: 99%

“…The severity of provoked symptoms was determined based on the Total Score (TS) of Anaphylaxis Scoring Aichi (ASCA). 3 We also used "TS/Pro" for the simultaneous expression of severity and threshold dose of antigen. "Pro" represents the cumulative protein dose of the allergen that provoked the symptoms, and the TS/Pro was obtained by simply dividing the TS by Pro.…”

Section: Development Of a Prediction Model For Severe Wheat Allergymentioning

confidence: 99%

See 3 more Smart Citations

Development of a prediction model for severe wheat allergy

Sugiura

Matsui²,

Furuta³

et al. 2017

Pediatric Allergy Immunology

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Section: Allergysupporting

confidence: 81%

Section: Development Of a Prediction Model For Severe Wheat Allergymentioning

confidence: 99%

“…To predict such severe reactions before OFC, we previously reported prediction models consisting of multiple factors for hen's egg 3 and cow's milk 4 allergy.…”

Section: Development Of a Prediction Model For Severe Wheat Allergymentioning

confidence: 99%

Section: Development Of a Prediction Model For Severe Wheat Allergymentioning

confidence: 99%

See 2 more Smart Citations

Development of a prediction model for severe wheat allergy

Sugiura

Matsui²,

Furuta³

et al. 2017

Pediatric Allergy Immunology

Self Cite

View full text Add to dashboard Cite

“…We have already evaluated the ASCA system in comparison with the Sampson's grading system [ 13 ]. TS significantly correlated to the Sampson's grading with some overlap between grades 2 and 3, because TS is a sum of multiorgan symptoms.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the results of oral food challenges conducted in specialized and general hospitals

Sakai¹,

Sasaki²,

Furuta³

et al. 2017

Asia Pacific Allergy

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BackgroundOral food challenge (OFC) tests are conducted in both specialized institutions and general hospitals. We aimed to compare the severity of the conditions of the patients between these 2 types of institutions in order to consider the role of such institutions in society.ObjectiveWe evaluated the results of OFC tests for hen's egg, cow's milk, and wheat that were conducted in a specialized institution (Aichi Children's Health and Medical Center [ACHMC], n = 835) and in 4 general hospitals (n = 327) in Aichi prefecture, Japan.MethodsThe symptoms provoked were scored using the total score (TS) of the Anaphylaxis Scoring Aichi scoring system in combination with the total ingested protein dose (Pro) before the appearance of allergic symptoms.ResultsThe total ingested dose of the challenge-positive patients in ACHMC was significantly less than that in the general hospitals (p < 0.01). The median TS of the provoked symptoms in ACHMC and the general hospitals did not differ to a statistically significant extent in the hen's egg or cow's milk challenges; however, the median TS in ACHMC was significantly lower than that in the general hospitals for the wheat challenge (p = 0.02). The median TS/Pro values in ACHMC were almost identical to the upper 25% of the TS/Pro values in the general hospitals, suggesting that the specialized institution usually managed more severe patients.ConclusionThe specialized institution performed OFC tests at a lower threshold dose, but provoked similar TSs to the general hospitals. This evaluation may help in optimizing the distribution of patients to general hospitals and specialized institutions.

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Food-Induced Anaphylaxis: an Update

Parrish

Kim

2018

Curr Allergy Asthma Rep

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Food allergy prevalence and FIA rates continue to rise, but FIA fatalities are stable. Basophil and mast cell activation tests promise more accurate identification of food triggers. Oral, sublingual, and epicutaneous immunotherapy can desensitize a significant portion of subjects. Epinephrine use for FIA remains sub-optimal. As the burden of food allergy continues to increase, it appears that the corresponding increase in research focused on this epidemic is beginning to bear fruit. The stable number of FIA fatalities in the face of an ongoing epidemic indicates lives have already been saved. The emergence of new diagnostic tests and interventional therapies may transform the management of FIA in the coming years.

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Development of a prediction model of severe reaction in boiled egg challenges

Abstract: This simple scoring prediction model was useful for avoiding risky OFC.

Cited by 34 publications

References 30 publications

Development of a prediction model for severe wheat allergy

Development of a prediction model for severe wheat allergy

Evaluation of the results of oral food challenges conducted in specialized and general hospitals

Food-Induced Anaphylaxis: an Update

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