Development of a Predictive Model for the Stabilizer Concentration Estimation in Microreservoir Transdermal Drug Delivery Systems Using Lipophilic Pressure-Sensitive Adhesives as Matrix/Carrier

Chenevas-Paule, Clémence; Wolff, Hans-Michael; Ashton, Mark; Schubert, M.; Dodou, Kalliopi

doi:10.1016/j.xphs.2017.01.031

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…34 PVP is indeed often used for its lipophilic properties in drug delivery systems to improve active ingredient dispersion in non-aqueous phases. 35 While there is no standard method to measure the hydrophobicity of a NP, 40% and 85% of the 3 and 10 nm PVP-coated AuNP adsorbed at the dodecane−water interface, while <15% of the citrate-coated AuNPs of similar size did (see Figure S3). This PVP-enhanced affinity for the oil phase was not observed for the largest sizes, possibly because of higher sedimentation properties due to their size.…”

Section: Resultsmentioning

confidence: 99%

“…The citrate coating induces more hydrophilic character to the AuNPs than PVP that is amphiphilic . PVP is indeed often used for its lipophilic properties in drug delivery systems to improve active ingredient dispersion in non-aqueous phases . While there is no standard method to measure the hydrophobicity of a NP, 40% and 85% of the 3 and 10 nm PVP-coated AuNP adsorbed at the dodecane–water interface, while <15% of the citrate-coated AuNPs of similar size did (see Figure S3).…”

Section: Resultsmentioning

confidence: 99%

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Nanoparticle Size and Coating Chemistry Control Foliar Uptake Pathways, Translocation, and Leaf-to-Rhizosphere Transport in Wheat

et al. 2019

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Nanoenabled foliar-applied agrochemicals can potentially be safer and more efficient than conventional products. However, limited understanding about how nanoparticle properties influence their interactions with plant leaves, uptake, translocation through the mesophyll to the vasculature, and transport to the rest of the plant prevents rational design. This study used a combination of Au quantification and spatial analysis to investigate how size (3, 10, or 50 nm) and coating chemistry (PVP versus citrate) of gold nanoparticles (AuNPs) influence these processes. Following wheat foliar exposure to AuNPs suspensions (∼280 ng per plant), adhesion on the leaf surface was increased for smaller sizes, and PVP-AuNPs compared to citrate-AuNPs. After 2 weeks, there was incomplete uptake of citrate-AuNPs with some AuNPs remaining on the outside of the cuticle layer. However, the fraction of citrate-AuNPs that had entered the leaf was translocated efficiently to the plant vasculature. In contrast, for similar sizes, virtually all of the PVP-AuNPs crossed the cuticle layer after 2 weeks, but its transport through the mesophyll cells was lower. As a consequence of PVP-AuNP accumulation in the leaf mesophyll, wheat photosynthesis was impaired. Regardless of their coating and sizes, the majority of the transported AuNPs accumulated in younger shoots (10−30%) and in roots (10−25%), and 5−15% of the NPs <50 nm were exuded into the rhizosphere soil. A greater fraction of larger sizes AuNPs (presenting lower ζ potentials) was transported to the roots. The key hypotheses about the NPs physical−chemical and plant physiology parameters that may matter to predict leaf-to-rhizosphere transport are also discussed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Nanoparticle Size and Coating Chemistry Control Foliar Uptake Pathways, Translocation, and Leaf-to-Rhizosphere Transport in Wheat

et al. 2019

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“…This work is complementary to our paper describing the development of a predictive model for the estimation of stabilizer concentration in non-polar pressure sensitive adhesives 13 .…”

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confidence: 78%

Development of a Predictive Model for the Long-Term Stability Assessment of Drug-In-Adhesive Transdermal Films Using Polar Pressure-Sensitive Adhesives as Carrier/Matrix

Chenevas-Paule

Wolff

Ashton

et al. 2017

Journal of Pharmaceutical Sciences

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“…The drug is released via zero-order kinetics in such systems providing uniform plasma drug concentrations. 24…”

Section: Membrane Moderated Transdermal Reservoir Patchesmentioning

confidence: 99%

Transdermal Patches: State of the Art

Sharma¹,

Thakur²,

Kaur³

et al. 2020

ijddt

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There is a considerable increase in preference for use of transdermal patches over conventional dosage forms owing to the advantages it possesses over them. Transdermal delivery of drugs has undergone rapid advancements through techniques like electroporation, microneedles, iontophoresis etc. This review is aimed at providing deep insight into transdermal technology and its types. An overview of the present market size of transdermal patches along with future prospects has been discussed. Transdermal products being manufactured by Indian pharmaceuticals also has been presented. Various components of transdermal patches being explored have been elaborated. After studying this review, it could be concluded that there are huge prospects for transdermal systems, and research aimed at the delivery of sparingly soluble drugs needs to be done to overcome limitations.

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Development of a Predictive Model for the Stabilizer Concentration Estimation in Microreservoir Transdermal Drug Delivery Systems Using Lipophilic Pressure-Sensitive Adhesives as Matrix/Carrier

Cited by 7 publications

References 39 publications

Nanoparticle Size and Coating Chemistry Control Foliar Uptake Pathways, Translocation, and Leaf-to-Rhizosphere Transport in Wheat

Nanoparticle Size and Coating Chemistry Control Foliar Uptake Pathways, Translocation, and Leaf-to-Rhizosphere Transport in Wheat

Development of a Predictive Model for the Long-Term Stability Assessment of Drug-In-Adhesive Transdermal Films Using Polar Pressure-Sensitive Adhesives as Carrier/Matrix

Transdermal Patches: State of the Art

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