Development of a Rapid Resolution Liquid Chromatographic Method Combined with Chemometrics for Quality Control of <i>Angelicae dahuricae</i> radix

Fan, Gang; Deng, Rui; Zhou, Lin; Meng, Xianli; Kuang, Tingting; Lai, Xianrong; Zhang, Jing; Zhang, Yi

doi:10.1002/pca.1358

Cited by 19 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PCA is an unsupervised pattern recognition method and OPLS‐DA is a supervised pattern recognition method. Both the two chemometric methods could be used for analysing, classifying and reducing the dimensionality of numerical datasets, and have been widely used in discriminating and comparing the composition of herbal medicines . In the present study, PCA and OPLS‐DA were carried out to provide more information about the chemical difference and to find potential chemical markers which contributed to the differences between Artemisiae argyi Folium and Artemisiae lavandulaefoliae Folium.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Artemisiae argyi Folium and Artemisiae lavandulaefoliae Folium by simultaneous determination of multi‐components with single reference standard method and chemometric analysis

Guo

Zhang

Xue

et al. 2018

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Comparison of Artemisiae argyi Folium and Artemisiae lavandulaefoliae Folium by simultaneous determination of multi‐components with single reference standard method and chemometric analysis

Guo

Zhang

Xue

et al. 2018

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

“…Oxypeucedanin, oxypeucedanin hydrate, imperatorin, and isoimperatorin are well known components of A. dahurica root [ 37 – 40 ]. In the present study, these four components were also found in ADE and the contents were calculated as 5.9, 0.23, 0.63, and 0.43 %, respectively.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the mechanisms of Angelica dahurica root extract-induced vasorelaxation in isolated rat aortic rings

Lee

Shin

Ham

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThe root of Angelica dahurica Bentham et Hooker (Umbelliferae) has been used as a traditional medicine for colds, headache, dizziness, toothache, supraorbital pain, nasal congestion, acne, ulcer, carbuncle, and rheumatism in China, Japan, and Korea. Interestingly, it has been used in the treatment of vascular diseases including hypertension. The aim of this study was to provide pharmacological evidence for the anti-hypertensive effect of A. dahurica by investigating the mechanism underlying its vasorelaxant effect.MethodsThe vasorelaxant effects of a 70 % methanol extract of the A. dahurica root (ADE) on rat thoracic aorta and its underlying mechanisms were assessed. Isolated rat aortic rings were suspended in organ chambers containing 10 ml Krebs-Henseleit (K-H) solution and placed between 2 tungsten stirrups and connected to an isometric force transducer. Changes in tension were recorded via isometric transducers connected to a data acquisition system.ResultsADE causes concentration-dependent relaxation in both endothelium-intact and endothelium-denuded aortic rings precontracted with phenylephrine (PE; 1 μM) or potassium (KCl; 60 mM) in K-H solution. And pre-treatment with ADE (1 mg/ml) inhibited calcium-induced vasocontraction of aortic rings induced by PE or KCl. However, ADE pre-treatment did not affect the contraction induced by PE or caffeine in Ca2+-free K-H solution.ConclusionsThese results suggested that the ADE has vasorelaxant effect and the vasorelaxant activity is mediated by endothelium-independent pathway that includes the blockade of extracellular calcium influx through the receptor-operated Ca2+ channel and voltage-dependent calcium channel pathways.

show abstract

“…In addition, authentication of TCMs based on their chemical profiles have been increasingly reported [12,20,21]. With the requirement of exploring minor differences of chemical profiles among different samples, statistical analysis such as HCA, PCA, PLS-DA, and OPLS-DA have been increasingly employed [22][23][24][25].…”

Section: Comparative Analysis Of Ultrafine Granular Powder and Decoctmentioning

confidence: 99%

Comparative Analysis of Ultrafine Granular Powder and Decoction Pieces of Salvia miltiorrhiza by UPLC-UV-MSn Combined with Statistical Analysis

Shen

Hou

Deng³

et al. 2016

Planta Med

View full text Add to dashboard Cite

is one of the most used herbal medicines for the treatment of a wide range of diseases in China. Decoction pieces and Chinese patent medicines from are the two main types of products used by patients. Other relatively new products of, like injections and ultrafine granular powder (D < 45 µm before granulation), are also increasingly used nowadays. With the growing usage of new products of , their chemical components and pharmacological effects, compared to the traditional decoction pieces, are attracting attention. In this work, the chemical profiles of two types of products from (one is traditional "decoction pieces", the other is modern "ultrafine granular powder") were compared via similarity analysis and discriminated via multivariate analysis, e.g., hierarchical cluster analysis, principal component analysis, and partial least squares discrimination analysis. A new adamantane stationary phase column was used to establish informative chemical profiles of them. The mean similarity correlation coefficient (> 0.987) revealed that ultrafine granular powder and decoction pieces of were consistent between each other and stable between different batches. Two types of products were clearly resolved from each other by hierarchical cluster analysis, principal component analysis, and partial least squares discrimination analysis. Compounds responsible for the discrimination results were further characterized by ESI-MS/MS. Eventually, 62 compounds selected as characteristic markers for evaluation were characterized or tentatively characterized. This result will facilitate the further comparison of these two types of products in pharmacology and pharmacokinetics.

show abstract

Development of a Rapid Resolution Liquid Chromatographic Method Combined with Chemometrics for Quality Control of Angelicae dahuricae radix

Abstract: This study revealed that sulphur-fumigation is an inappropriate approach for processing crude drugs and should be prohibited, and that the proposed RRLC method combined with chemometrics demonstrated an efficient strategy for quality control of Baizhi.

Cited by 19 publications

References 27 publications

Comparison of Artemisiae argyi Folium and Artemisiae lavandulaefoliae Folium by simultaneous determination of multi‐components with single reference standard method and chemometric analysis

Comparison of Artemisiae argyi Folium and Artemisiae lavandulaefoliae Folium by simultaneous determination of multi‐components with single reference standard method and chemometric analysis

Investigation of the mechanisms of Angelica dahurica root extract-induced vasorelaxation in isolated rat aortic rings

Comparative Analysis of Ultrafine Granular Powder and Decoction Pieces of Salvia miltiorrhiza by UPLC-UV-MSn Combined with Statistical Analysis

Contact Info

Product

Resources

About