Development of a sensitive liquid chromatography method coupled with a tandem mass spectrometric detection for the clinical analysis of vinflunine and 4-O-deacetyl vinflunine in blood, urine and faeces

Zorza, Grégoire; Heugen, J.C. Van; Graeve, J. De; Puozzo, C.

doi:10.1016/j.jchromb.2007.03.030

Cited by 13 publications

(12 citation statements)

References 9 publications

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“…The analysis of vinca alkaloids has been carried out on plant extracts, [398][399][400][401][402][403] pharmaceutical formulations, 316,404 biological samples 358,359,[405][406][407][408][409][410][411][412][413][414][415][416][417][418][419][420]421 and environmental samples. 18,19,134,307,422 Vinca alcaloid extraction from plants was generally performed by ultrasound in acid media followed by LLE.…”

Section: Antitubulin Agentsmentioning

confidence: 99%

Antineoplastic drugs and their analysis: a state of the art review

Guichard

Guillarme

Bonnabry

et al. 2017

Analyst

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The number of patients suffering from cancer is constantly increasing and, consequently, the number of different chemotherapy treatments administered is increasing. Given the high reactivity and toxicity of antineoplastic drugs, analytical methods are required in all pharmaceutical fields, from drug development to their elimination in wastewater; including formulation quality control, environment and human exposure and therapeutic drug monitoring. The aim of this paper is to provide an overview of the analytical methods available for the determination of antineoplastic drugs in different matrices such as pharmaceutical formulations, biological and environmental samples. The applicability and performance of the reported methods will be critically discussed, with focus on the most commonly used antineoplastic drugs. Only conventional compounds and small molecules for targeted therapy will be considered in the present review.

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Section: Antitubulin Agentsmentioning

confidence: 99%

Antineoplastic drugs and their analysis: a state of the art review

Guichard

Guillarme

Bonnabry

et al. 2017

Analyst

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“…The clear supernatant can be injected on to the LC-MS system. Van Heugen et al (2001) and Zorza et al (2007) both use the same protein-precipitation procedure for the extraction of vinorelbine, vinflunine and metabolites from blood and plasma. These platforms however use 6 mL of a methanol-acetonitrile mixture for the precipitation of 500 μL plasma or whole blood.…”

Section: Sample Pre-treatmentmentioning

confidence: 99%

“…Urine can be diluted with an appropriate buffer and directly injected on the LC-MS system (Van Heugen et al, 2001;Zorza et al, 2007). Extraction of vinorelbine, vinflunine and metabolites from feces has also been described.…”

Section: Sample Pre-treatmentmentioning

confidence: 99%

“…1(C, D)]. For vinflunine the major MS/MS fragment is found at m/z 160 instead of m/z 122 (Zorza et al, 2007). Zhou et al (2005) described a method for the identification of vinca-alkaloids from a crude extract of the Catharanthus roseus plant.…”

Section: Detectionmentioning

confidence: 99%

“…Van Heugen et al (2001) and Zorza et al (2007) reported absorption of vinca-alkaloids to the walls of test tubes and advised to use silicon coated glass tubes in order to avoid this problem. An alternative is to store all stock solutions in methanol and prepare all further dilutions in plasma (Van Tellingen et al, 1991).…”

Section: Complications In the Bioanalysis Of Vinca-alkaloidsmentioning

confidence: 99%

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High‐performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca‐alkaloids in biological matrices: a concise survey from the literature

Damen

Rosing

Schellens

et al. 2009

Biomedical Chromatography

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The bioanalysis of vinca-alkaloids has been investigated extensively. High-performance liquid chromatography coupled to ultraviolet, fluorescence or electrochemical detection have been described. During recent years liquid chromatography coupled with mass spectrometry (LC-MS) has become the first choice for the quantitative bioanalysis of the vinca anticancer agents. This paper reviews recent methods for the bio-analysis of vinca-alkaloids using LC-MS, supplemented with our own experience. We will focus on sample pre-treatment, chromatography and MS detection and pay attention to problems which can occur during the bioanalysis of vinca-alkaloids. These problems encounter carry-over and absorption effects and solutions will be provided how to circumvent these problems.

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A validated LC‐MS/MS method for the determination of vinflunine in plasma and its application to pharmacokinetic studies

Lü

et al. 2011

Biomedical Chromatography

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A rapid, simple and sensitive LC-MS/MS method for the quantification of vinflunine in plasma was developed and validated. The analysis involved a simple liquid-liquid extraction. After making alkaline with NaOH, plasma was extracted with methyl tert-butyl ether and the organic extract was then evaporated and the residue was reconstituted in mobile phase. The reconstituted solution was injected into an HPLC system and was subjected to reverse-phase HPLC on a 5 µm ODS-3 column at a flow-rate of 0.2 mL/min. The mobile phase consisted of ammonium acetate (0.02 mol/L, pH = 3.0) and acetonitrile (20:80). Vinflunine was detected in the single ion monitoring mode using target ions at m/z 817.4/160.1/142.3 for vinflunine and m/z 447.2/128.3/112.1 for gefitinib (internal standard). Standard curves were linear over the concentration range of 5-1000 ng/mL. The mean predicted concentrations of the quality control samples deviated by less than 2% from the corresponding nominal values; the intra-assay and inter-assay precisions of the assay were within 7% relative standard deviation. The extraction recovery of vinflunine was more than 80%. The validated assay was applied to a pharmacokinetic study of vinflunine in plasma following the administration of a single vinflunine injection (2 mg/kg).

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Development of a sensitive liquid chromatography method coupled with a tandem mass spectrometric detection for the clinical analysis of vinflunine and 4-O-deacetyl vinflunine in blood, urine and faeces

Cited by 13 publications

References 9 publications

Antineoplastic drugs and their analysis: a state of the art review

Antineoplastic drugs and their analysis: a state of the art review

High‐performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca‐alkaloids in biological matrices: a concise survey from the literature

A validated LC‐MS/MS method for the determination of vinflunine in plasma and its application to pharmacokinetic studies

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