2021
DOI: 10.1007/s10337-021-04010-5
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Development of a Simple and Sensitive Pre-column Derivatization HPLC Method for the Quantitative Analysis of Miglitol Intermediates

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Cited by 2 publications
(1 citation statement)
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“…As one of the main active components, 1-methyl hydantoin has good antitussive and anti-inflammatory effects [20]. However, the pre-column derivatization was used in this experiment due to the harsh chromatographic conditions (using water as mobile phase accelerates the wear on the chromatographic column) in Chinese Pharmacopoeia (2020 edition) and there were problems such as low sensitivity and poor resolution [21,22]. 1-methyl hydantoin was derivatized with benzoylchloride, having a chromogenic group to impart its chromophore in structure to form benzoyl-1-methyl hydantoin (bzmh) for HPLC detection [23].…”
Section: Introductionmentioning
confidence: 99%
“…As one of the main active components, 1-methyl hydantoin has good antitussive and anti-inflammatory effects [20]. However, the pre-column derivatization was used in this experiment due to the harsh chromatographic conditions (using water as mobile phase accelerates the wear on the chromatographic column) in Chinese Pharmacopoeia (2020 edition) and there were problems such as low sensitivity and poor resolution [21,22]. 1-methyl hydantoin was derivatized with benzoylchloride, having a chromogenic group to impart its chromophore in structure to form benzoyl-1-methyl hydantoin (bzmh) for HPLC detection [23].…”
Section: Introductionmentioning
confidence: 99%