Development of a Smart Pump for Monitoring and Controlling Intraocular Pressure

Bello, Simon; Malavade, Sharad; Passaglia, Christopher L.

doi:10.1007/s10439-016-1735-y

Cited by 21 publications

(19 citation statements)

References 30 publications

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“…Measuring vital physiological pressures (e.g., diaphragmatic contraction pressure, intraarticular pressure, intraocular pressure, and intracranial pressure) is important for monitoring health status, preventing potential damage to specific organs induced by accumulated internal forces, and monitoring and controlling novel mechanical stimulation approaches . On the basis of their sensing mechanisms, bioresorbable pressure sensors can be classified into three types, i.e., piezoresistive, capacitive, and piezoelectric pressure sensors …”

Section: Device Components For Bioresorbable Electronicsmentioning

confidence: 99%

Bioresorbable Electronic Implants: History, Materials, Fabrication, Devices, and Clinical Applications

Doo

Kang

Lee

et al. 2019

Adv Healthcare Materials

102

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Medical implants, either passive implants for structural support or implantable devices with active electronics, have been widely used for the diagnosis and treatment of various diseases and clinical issues. These implants offer various functions, including mechanical support of biological structures in orthopedic and dental applications, continuous electrophysiological monitoring and feedback of electrical stimulation in neuronal and cardiac applications, and controlled drug delivery while maintaining arterial structure in drug‐eluting stents. Although these implants exhibit long‐term biocompatibility, surgery for their retrieval is often required, which imposes physical, biological, and economical burdens on the patients. Therefore, as an alternative to such secondary surgeries, bioresorbable implants that disappear after a certain period of time inside the body, including bioresorbable active electronics, have been highlighted recently. This review first discusses the historical background of medical implants and briefly define related terminology. Representative examples of non‐degradable medical implants for passive structural support and/or for diagnosis and therapy with active electronics are also provided. Then, recent progress in bioresorbable active implants composed of biosignal sensors, actuators for therapeutics, wireless power supply components, and their integrated systems are reviewed. Finally, clinical applications of these bioresorbable electronic implants are exemplified with brief conclusion and future outlook.

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Section: Device Components For Bioresorbable Electronicsmentioning

confidence: 99%

Bioresorbable Electronic Implants: History, Materials, Fabrication, Devices, and Clinical Applications

Doo

Kang

Lee

et al. 2019

Adv Healthcare Materials

102

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“…This issue has led several groups to concentrate their efforts on manometer-controlled, short-term IOP elevations as a means of studying various factors contributing to ONH susceptibility (Crowston et al, 2015). There are also efforts to create longer-duration IOP-control systems in rodents (Bello et al, 2016). …”

Section: Animal Models Of Glaucomamentioning

confidence: 99%

Biomechanical aspects of axonal damage in glaucoma: A brief review

Tamm

Ethier

Dowling

et al. 2017

Experimental Eye Research

100

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The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microarchitecture and anatomy; intraocular pressure (IOP); and cerebrospinal fluid pressure (CSFp). We note that connective tissue factors can vary significantly from one individual to the next, as well as regionally within an eye, and that the understanding of ONH biomechanics is hindered by anatomical differences between small-animal models of glaucoma (rats and mice) and humans. Other challenges of using animal models of glaucoma to study the role of biomechanics include the complexity of assessing the degree of glaucomatous progression; and inadequate tools for monitoring and consistently elevating IOP in animal models. We conclude with a consideration of important open research questions/challenges in this area, including: (i) Creating a systems biology description of the ONH; (ii) addressing the role of astrocyte connective tissue remodeling and reactivity in glaucoma; (iii) providing a better characterization of ONH astrocytes and non-astrocytic constituent cells; (iv) better understanding the role of ONH astrocyte phagocytosis, proliferation and death; (v) collecting gene expression and phenotype data on a larger, more coordinated scale; and (vi) developing an implantable IOP sensor.

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“…M easuring vital biophysiological pressures such as the pressure of diaphragmatic contraction, intraarticular pressure, intraabdominal pressure, intraocular pressure, intracranial pressure, etc. is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches of using mechanical stimulation for tissue regeneration (1)(2)(3).…”

mentioning

confidence: 99%

Biodegradable Piezoelectric Force Sensor

Curry

Chorsi

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

319

251

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Measuring vital physiological pressures is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches of using mechanical stimulation for tissue regeneration. Pressure sensors are often required to be implanted and directly integrated with native soft biological systems. Therefore, the devices should be flexible and at the same time biodegradable to avoid invasive removal surgery that can damage directly interfaced tissues. Despite recent achievements in degradable electronic devices, there is still a tremendous need to develop a force sensor which only relies on safe medical materials and requires no complex fabrication process to provide accurate information on important biophysiological forces. Here, we present a strategy for material processing, electromechanical analysis, device fabrication, and assessment of a piezoelectric Poly-l-lactide (PLLA) polymer to create a biodegradable, biocompatible piezoelectric force sensor, which only employs medical materials used commonly in Food and Drug Administration-approved implants, for the monitoring of biological forces. We show the sensor can precisely measure pressures in a wide range of 0-18 kPa and sustain a reliable performance for a period of 4 d in an aqueous environment. We also demonstrate this PLLA piezoelectric sensor can be implanted inside the abdominal cavity of a mouse to monitor the pressure of diaphragmatic contraction. This piezoelectric sensor offers an appealing alternative to present biodegradable electronic devices for the monitoring of intraorgan pressures. The sensor can be integrated with tissues and organs, forming self-sensing bionic systems to enable many exciting applications in regenerative medicine, drug delivery, and medical devices.

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Development of a Smart Pump for Monitoring and Controlling Intraocular Pressure

Cited by 21 publications

References 30 publications

Bioresorbable Electronic Implants: History, Materials, Fabrication, Devices, and Clinical Applications

Bioresorbable Electronic Implants: History, Materials, Fabrication, Devices, and Clinical Applications

Biomechanical aspects of axonal damage in glaucoma: A brief review

Biodegradable Piezoelectric Force Sensor

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