Development of a system by atomization for the formation of polymeric particles in micro and sub-micro scales

Fernandes, Lenita S.L.; Cellet, Thelma S.P.; Souza, E. M. B. D.; Sayer, Cláudia; Rubira, Adley F.; Dariva, Cláudio; Oliveira, Jackson Araújo de

doi:10.1016/j.colsurfa.2014.03.020

Cited by 3 publications

(3 citation statements)

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“…Liquid atomization is a unit operation that performs the disintegration of a liquid stream into droplets after forced passage in a nozzle. The characteristics of the generated spray are affected by nozzle type, the operational conditions and the physical properties of the dispersed phase (Mandato et al 2012;Fernandes et al 2014). In liquid atomization with two-fluid nozzles, the gas phase is displaced at high speed (> 100 m/s), which causes high shear rates with the liquid stream and, consequently, promotes the formation of liquid droplets (Mandato et al 2012;Kemp et al 2013;Heng et al 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Compared to conventional homogenization methods (mechanical agitation, high pressure homogenizer, ultrasound, etc. ), atomization with a two-fluid nozzle is a simple method (requires only pump, gas line and atomization nozzle), requires low installation and operation cost and is easy to scale-up (Fernandes et al (2014); Kemp et al 2016). In addition to the advantages mentioned, the strict control of droplet size makes this method a potential candidate for use in the fabrication of polymer particles (Kemp et al 2016;Pereira et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Mishra and Chatterjee reported the success of an atomization apparatus for the manufacture of polystyrene, poly(methyl methacrylate), polyacrylonitrile and styrene-based copolymers nanoparticles (Mishra and Chatterjee 2011;Chatterjee and Mishra 2012). In our previous study, a two-fluid nozzle was used to generate monomer droplets in miniemulsion polymerization reactions, which allowed the obtaining of nanoparticles with average sizes between 40 and 300 nm (Fernandes et al 2014). Despite this, there is an urgent need to establish cause-effect relationships between the operational conditions of the polymerization reactions and particle size using an atomization apparatus.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of methyl methacrylate-based polymer particles by miniemulsion and combined miniemulsion/emulsion polymerization using an atomization apparatus

Fernandes

Jesus

Padilha

et al. 2020

Braz. J. Chem. Eng.

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The present study evaluated the fabrication of methyl methacrylate-based polymer nanoparticles by miniemulsion and combined miniemulsion/emulsion polymerization using an atomization apparatus with two-fluid nozzle. In both reactions, the effects of the operational conditions were investigated on the morphology and particle size distribution of polymer particles. After multivariate analysis, it was observed that the size of the poly(methyl methacrylate) particles is a function of gas pressure in the experiments stabillized by sodium lauryl sulfate (SLS), but this did not occur in reactions stabillized by inorganic and polymeric stabilizers. The use of inorganic stabilizer made possible the fabrication of polymer particles smaller than 300 nm. In combined miniemulsion/emulsion polymerization with SLS, high concentrations of surfactant (> 0.4% w/w) and intermittent monomer feeding enabled not only an increase of the solid concentrations, but also a reduction of particle size. In addition, styrene-methyl methacrylate nanoparticles were successfully obtained (< 30 nm), according to dynamic light scattering and transmission electron microscopic analyses.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fabrication of methyl methacrylate-based polymer particles by miniemulsion and combined miniemulsion/emulsion polymerization using an atomization apparatus

Fernandes

Jesus

Padilha

et al. 2020

Braz. J. Chem. Eng.

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Controlled Release of Vitamin B‐12 Using Hydrogels Synthesized by Free Radical and RAFT Copolymerization in scCO₂

Pérez‐Salinas

Rosas‐Aburto

Antonio-Hernández

et al. 2016

Macromolecular Symposia

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Summary Research in polymer network synthesis is mostly focused on materials with absorbent or controlled‐release properties. They are important in healthcare applications. Free radical copolymerization is the main route to obtain gels, using monomers and crosslinking agents, but the materials produced by this route are highly heterogeneous. These heterogeneities reduce the efficiency of chemical compounds used in controlled‐release applications. Our research is focused on creating new routes of polymer synthesis to reduce these heterogeneities. In this article, we compare gels synthesized by conventional free radical and by reversible addition‐fragmentation chain transfer (RAFT) copolymerization of acrylic monomers in supercritical carbon dioxide. These gels are evaluated for controlled drug delivery applications with vitamin B12. The materials were characterized by scanning electron microscopy (SEM), nitrogen adsorption (BET), differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA). These characterization techniques allowed us to determine the morphology and texture of each hydrogel and to explain how vitamin release performance is affected by these characteristics of the hydrogel.

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Nanoprecipitation of particles by atomization of a polymer solution in circulating medium

Pereira

Sousa

Cellet

et al. 2017

Mater. Res. Express

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Development of a system by atomization for the formation of polymeric particles in micro and sub-micro scales

Cited by 3 publications

References 56 publications

Fabrication of methyl methacrylate-based polymer particles by miniemulsion and combined miniemulsion/emulsion polymerization using an atomization apparatus

Fabrication of methyl methacrylate-based polymer particles by miniemulsion and combined miniemulsion/emulsion polymerization using an atomization apparatus

Controlled Release of Vitamin B‐12 Using Hydrogels Synthesized by Free Radical and RAFT Copolymerization in scCO₂

Nanoprecipitation of particles by atomization of a polymer solution in circulating medium

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Development of a system by atomization for the formation of polymeric particles in micro and sub-micro scales

Cited by 3 publications

References 56 publications

Fabrication of methyl methacrylate-based polymer particles by miniemulsion and combined miniemulsion/emulsion polymerization using an atomization apparatus

Fabrication of methyl methacrylate-based polymer particles by miniemulsion and combined miniemulsion/emulsion polymerization using an atomization apparatus

Controlled Release of Vitamin B‐12 Using Hydrogels Synthesized by Free Radical and RAFT Copolymerization in scCO2

Nanoprecipitation of particles by atomization of a polymer solution in circulating medium

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Controlled Release of Vitamin B‐12 Using Hydrogels Synthesized by Free Radical and RAFT Copolymerization in scCO₂