Geodetic reference frames were established decades ago by classical surveying techniques; however, due to biases caused by poor observation techniques and effects of plate tectonic, the origins are poorly defined and adopted. Due to plate tectonics, the relative position of points changes with time and therefore, datum such as MINNA requires redefinition at regular intervals to be in consonant with geodetic reference frame in use. Therefore, with the Continuously Operating Reference Stations (CORS) network in Nigeria, these biases can be mitigated and a more accurate datum transformation parameter between MINNA datum and ITRF can be developed and adopted. Therefore, this study presents the results of time-dependent datum transformation parameters proposed for Nigeria using 5-years GNSS data (from 2011 to 2015) obtained from the NigNet CORS. GAMIT GNSS scientific processing software was deployed in processing, while GLOBK was used for frame definition and datum transformation parameters development. Statistical assessments show the validity of the transformation parameters. The correlation value was found to be 1, root mean square error 0.00411, normalized mean absolute error 1.267E−10 and reliability index 1.0.