Development of a viscoelastic phantom for ultrasound and MR elastography satisfying the QIBA acoustic specifications

Suga, Mikio; Usumura, Masashi; Kishimoto, Riwa; Mizoguchi, Takeru; Yamaguchi, Tadashi; Obata, Takayuki

doi:10.1109/ius46767.2020.9251680

Cited by 5 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The weight of the phantom was measured immediately after construction (0 months) and after the third examination (18 months). In a MRE study using a vibration frequency of 62.5 Hz [16], the tan δ (= G" / G') of the liver was reported to be approximately 0.3 for both healthy volunteers and patients with liver fibrosis [19]. The relative concentration of the base components in the gel were adjusted to match that value of tan δ.…”

Section: Phantommentioning

confidence: 99%

“…As noted earlier, the profile had not been released at the time we developed this phantom. A new phantom that satisfies the QIBA specifications has since been created [16] and the longitudinal change to the characteristics of the phantom after 28 months are included as S1 Data. Although measurements were not made at 6 months intervals, changes to the SWS and SWSmre were less than 10%.…”

Section: Plos Onementioning

confidence: 99%

“…In an effort to obtain higher stability, we have developed a phantom made of polyacrylamide (PAAm) gel that can be measured with both MRE and US SWE [16]. The PAAm gel is composed of a three-dimensional network polymer and a large amount of liquid, which is the source of the MR signal.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Longitudinal stability of a multimodal visco-elastic polyacrylamide gel phantom for magnetic resonance and ultrasound shear-wave elastography

et al. 2021

Self Cite

View full text Add to dashboard Cite

We evaluated the long-term stability of a newly developed viscoelastic phantom made of polyacrylamide (PAAm) gel for magnetic resonance elastography (MRE) and ultrasound-based shear-wave elastography (US SWE). The stiffness of the cylindrical phantom was measured at 0, 13 and 18 months. Storage and loss moduli were measured with MRE, and shear-wave speed (SWS) was measured with US SWE. Long-term stability was evaluated in accordance with the Quantitative Imaging Biomarker Alliance (QIBA) profiles for each modality. The initial storage and loss moduli of the phantom were 5.01±0.22 and 1.11±0.15 respectively, and SWS was 2.57±0.04 m/s. The weight of the phantom decreased by 0.6% over the 18 months. When measured with MRE, the stiffness of the phantom decreased and changes to the storage and loss moduli were -3.0% and -4.6% between 0 and 13 months, and -4.3% and 0.0% between 0 and 18 months. The US measurements found that SWS decreased by 2.4% over the first 13 months and 3.6% at 18 months. These changes were smaller than the tolerances specified in the QIBA profiles, so the viscoelastic PAAm gel phantom fulfilled the condition for long-term stability. This new phantom has the potential to be used as a quality assurance and quality control phantom for MRE and US SWE.

show abstract

Section: Phantommentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

See 1 more Smart Citation

Longitudinal stability of a multimodal visco-elastic polyacrylamide gel phantom for magnetic resonance and ultrasound shear-wave elastography

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…In Japan, J-QIBA was established in 2015 as an initiative of the Japan Radiological Society (JRS) [110]. The Japanese Society of Ultrasonics in Medicine (JSUM) collaborates mainly on the standardization of shear wave elastography and also carries out its own activities [111][112][113]. QIBA and J-QIBA activities to standardize QUS parameters and establish ultrasonic biomarkers include evaluation of clinical data collected at various clinical facilities; in addition, these entities are active in the construction of standardized phantoms, establishment of computer simulation methods, and standardization of diagnostic protocols.…”

Section: Ultrasonic Biomarkersmentioning

confidence: 99%

Basic concept and clinical applications of quantitative ultrasound (QUS) technologies

Yamaguchi

2021

J Med Ultrasonics

Self Cite

View full text Add to dashboard Cite

In the field of clinical ultrasound, the full digitalization of diagnostic equipment in the 2000s enabled the technological development of quantitative ultrasound (QUS), followed by multiple diagnostic technologies that have been put into practical use in recent years. In QUS, tissue characteristics are quantified and parameters are calculated by analyzing the radiofrequency (RF) echo signals returning to the transducer. However, the physical properties (and pathological level structure) of the biological tissues responsible for the imaging features and QUS parameters have not been sufficiently verified as there are various conditions for observing living tissue with ultrasound and inevitable discrepancies between theoretical and actual measurements. A major issue of QUS in clinical application is that the evaluation results depend on the acquisition conditions of the RF echo signal as the source of the image information, and also vary according to the model of the diagnostic device. In this paper, typical examples of QUS techniques for evaluating attenuation, speed of sound, amplitude envelope characteristics, and backscatter coefficient in living tissues are introduced. Exemplary basic research and clinical applications related to these technologies, and initiatives currently being undertaken to establish the QUS method as a true tissue characterization technology, are also discussed.

show abstract

“…We have developed original multimodal phantoms for US and MRE and evaluated the agreement between SWS obtained from US and MRE [16]. We have also made a viscoelastic phantom of stiffness representing fibrotic liver or healthy thyroid that fulfills the QIBA acoustics specifications, which include speed of sound and attenuation coefficient [17,18].…”

Section: Introductionmentioning

confidence: 99%

Shear wave speed measurement bias in a viscoelastic phantom across six ultrasound elastography systems: a comparative study with transient elastography and magnetic resonance elastography

et al. 2022

Self Cite

View full text Add to dashboard Cite

Purpose To quantify the bias of shear wave speed (SWS) measurements in a viscoelastic phantom across six different ultrasound (US) systems and to compare the SWS with those from transient elastography (TE) and magnetic resonance elastography (MRE). Methods A viscoelastic phantom of stiffness representing fibrotic liver or healthy thyroid was measured with nine (linear probe) and 10 (convex probe) modes of six different US-based shear wave elastography (SWE) systems using linear and convex probes. SWS measurements of three regions of interest were repeated thrice at two focal depths, coupling the probe to the phantom using a jig. An MRE system using three motion-encoding gradient frequencies of 60, 90, and 120 Hz and TE were also used to measure the stiffness of the phantom. Results The SWS from different SWE systems had mean coefficients of variation of 9.0–9.2% and 5.4–5.6% with linear and convex probes, respectively, in viscoelastic phantom measurement. The focal depth was a less significant source of SWS variability than the system. The total average SWS obtained with US-SWE systems was 19.9% higher than that obtained with MRE at 60 Hz, which is commonly used in clinical practice, and 31.5% higher than that obtained with TE using the M probe. Conclusions Despite the measurement biases associated with the SWE systems, biases were not necessarily consistent, and they changed with the probes used and depth measured. The SWS of the viscoelastic phantom obtained using different modalities increased according to the shear wave frequency used.

show abstract

Development of a viscoelastic phantom for ultrasound and MR elastography satisfying the QIBA acoustic specifications

Cited by 5 publications

References 9 publications

Longitudinal stability of a multimodal visco-elastic polyacrylamide gel phantom for magnetic resonance and ultrasound shear-wave elastography

Longitudinal stability of a multimodal visco-elastic polyacrylamide gel phantom for magnetic resonance and ultrasound shear-wave elastography

Basic concept and clinical applications of quantitative ultrasound (QUS) technologies

Shear wave speed measurement bias in a viscoelastic phantom across six ultrasound elastography systems: a comparative study with transient elastography and magnetic resonance elastography

Contact Info

Product

Resources

About