Development of an acetone sensor using nanostructured Co<sub>3</sub>O<sub>4</sub> thin films for exhaled breath analysis

Srinivasan, P. Bala; Kulandaisamy, Arockia Jayalatha; Mani, Ganesh Kumar; Babu, K. Jayanth; Tsuchiya, Kazuyoshi; Rayappan, John Bosco Balaguru

doi:10.1039/c9ra04230j

Cited by 55 publications

(32 citation statements)

References 66 publications

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“…The Occupational Safety and Health Administration states that the allowable human exposure level of acetone is 1000 ppm in industries. Different nanostructured cobalt oxide sensing elements were synthesized using a spray pyrolysis method at different deposition temperatures (473 to 773 K) [ 117 ]. It was found that the nanostructured material was more sensitive to acetone when analyzing different solvents such as acetone, EtOH, NH 3 , xylene, toluene, and acetaldehyde.…”

Section: Nanosensor Array E-nose For Exhaled Breath Diagnosismentioning

confidence: 99%

“…The Occupational Safety and Health Administration states that the allowable human exposure level of acetone is 1000 ppm in industries. Different nanostructured cobalt oxide sensing elements were synthesized using a spray pyrolysis method at different deposition temperatures (473 to 773 K) [117]. It was found that the nanostructured material was more Nanostructured materials with various morphologies, including nanorods, nanowires, nanosheets, and nanofibers, have been developed for e-nose applications because their large surface area-to-volume greatly facilitates the conversion of gas response into electric signals.…”

Section: Metal Oxide-based Electrochemical Sensor Array For Disease Diagnosismentioning

confidence: 99%

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Recent Trends in Exhaled Breath Diagnosis Using an Artificial Olfactory System

et al. 2021

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Artificial olfactory systems are needed in various fields that require real-time monitoring, such as healthcare. This review introduces cases of detection of specific volatile organic compounds (VOCs) in a patient’s exhaled breath and discusses trends in disease diagnosis technology development using artificial olfactory technology that analyzes exhaled human breath. We briefly introduce algorithms that classify patterns of odors (VOC profiles) and describe artificial olfactory systems based on nanosensors. On the basis of recently published research results, we describe the development trend of artificial olfactory systems based on the pattern-recognition gas sensor array technology and the prospects of application of this technology to disease diagnostic devices. Medical technologies that enable early monitoring of health conditions and early diagnosis of diseases are crucial in modern healthcare. By regularly monitoring health status, diseases can be prevented or treated at an early stage, thus increasing the human survival rate and reducing the overall treatment costs. This review introduces several promising technical fields with the aim of developing technologies that can monitor health conditions and diagnose diseases early by analyzing exhaled human breath in real time.

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Section: Nanosensor Array E-nose For Exhaled Breath Diagnosismentioning

confidence: 99%

“…The Occupational Safety and Health Administration states that the allowable human exposure level of acetone is 1000 ppm in industries. Different nanostructured cobalt oxide sensing elements were synthesized using a spray pyrolysis method at different deposition temperatures (473 to 773 K) [117]. It was found that the nanostructured material was more Nanostructured materials with various morphologies, including nanorods, nanowires, nanosheets, and nanofibers, have been developed for e-nose applications because their large surface area-to-volume greatly facilitates the conversion of gas response into electric signals.…”

Section: Metal Oxide-based Electrochemical Sensor Array For Disease Diagnosismentioning

confidence: 99%

Recent Trends in Exhaled Breath Diagnosis Using an Artificial Olfactory System

et al. 2021

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“…[ 7 ] Indeed, the presence of 1.8 ppm of acetone in exhaled breath indicates the Diabetic Ketoacidosis (DKA). [ 8 ] Another highly toxic and harmful volatile inorganic compound, which is also extremely dangerous for plants, aquatic and land animals and for human health, is nitrogen dioxide (NO 2 ). The main source of NO 2 is the combustion of fossil fuels and the exhaust of motor engines.…”

Section: Introductionmentioning

confidence: 99%

Novel Christmas Branched Like NiO/NiWO₄/WO₃ (p–p–n) Nanowire Heterostructures for Chemical Sensing

Kaur

Zappa

Maraloiu

et al. 2021

Adv Funct Materials

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Establishing a platform comprising different nanostructured oxides is an emerging idea to develop highly sensitive and selective sensing devices. Herein, novel 3D-heterostructures (p-p-n) consisting of 1D nanowires of NiO and WO 3 along with their intermediate reactive product, i.e., NiWO 4 seed, are produced by a two-steps vapor phase growth method. In-depth morphological and structural investigations describing the growth mechanism of these heterostructures are presented. Finally, the p-p-n heterostructures are integrated into conductometric sensing devices and their performances are investigated toward different gases. It is observed that by modulating the charge-carrier transport with temperature, the heterostructure sensors exhibit selective behavior toward different gas analytes. Indeed, at 300 °C, the heterostructure sensors show relatively selective behavior toward NO 2 , while at 400 °C, high selectivity toward VOCs is observed. The improvement in sensing performances is mainly based on charge carrier transport through the two interfaces (one at WO 3 /NiWO 4 (n-p) and the other at NiWO 4 /NiO (p-p)) and the modulation of charge carriers in the electron depletion layer of WO 3 and hole accumulation layer of NiO and NiWO 4 . The remarkable performance of these complex heterostructures with low ppb-level detection limits makes them excellent candidates for chemical/ gas sensing applications in e-noses.

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“…The presence of 1.8 ppm of acetone in exhaled breath indicates the diabetic ketoacidosis (DKA). [ 21 ] Moreover, as acetone possess fat metabolic nature its concentration dependence on the exhaled breath can also be correlated to the fat loss. [ 22 ] If the exhaled breath analysis shows the presence of more than 1.71 ppm of acetone, then the patient is suffering from type‐2 diabetic mellitus, while 2.19 ppm of acetone in exhaled breath is the indication of type‐1 diabetes.…”

Section: Introductionmentioning

confidence: 99%

SAM Functionalized ZnO Nanowires for Selective Acetone Detection: Optimized Surface Specific Interaction Using APTMS and GLYMO Monolayers

Singh

Kaur

Drera

et al. 2020

Adv Funct Materials

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In modern days, self‐assembled monolayer (SAM) functionalized surfaces represent an interesting tool for the development of ultrasensitive and selective sensing platforms for the detection of chemical substances such as biomolecules and gases. The ability of SAM to generate different functional groups on a single surface such as zinc oxide (ZnO) can be used to immobilize biomolecules and detect different analytes such as gases, proteins, etc. Herein, SAM functionalized ZnO NW‐based sensors are developed for acetone exhaled breath analysis. ZnO NWs are synthesized using a vapor–liquid–solid mechanism and their functionalization is done with two different SAMs, i.e., (3‐aminopropyl)trimethoxysilane (APTMS) and 3‐glycidoxypropyltrimethoxysilane (GLYMO). The enhancement in the electron depletion layer resistance (and also width) due to the capturing of electrons from the ZnO NWs surface by APTMS and GLYMO molecules is found to be the major reason in their superior sensing performances. The amine (–NH2) groups of APTMS monolayer enhance the sensors selectivity toward acetone due to their reactions with acetone molecules, which produce imine in addition to water molecules. Moreover, after the functionalization with APTMS SAMs, the detection limits of the sensors are improved from 6 to 0.5 ppm, which makes these devices potential candidates for acetone exhaled breath analysis.

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Development of an acetone sensor using nanostructured Co₃O₄ thin films for exhaled breath analysis

Abstract: We report the fabrication of a breath sensor using nanostructured Co3O4 thin films for the detection of acetone in exhaled breath, which is one of the prominent bio-markers of Diabetic Ketoacidosis (DKA).

Cited by 55 publications

References 66 publications

Recent Trends in Exhaled Breath Diagnosis Using an Artificial Olfactory System

Recent Trends in Exhaled Breath Diagnosis Using an Artificial Olfactory System

Novel Christmas Branched Like NiO/NiWO₄/WO₃ (p–p–n) Nanowire Heterostructures for Chemical Sensing

SAM Functionalized ZnO Nanowires for Selective Acetone Detection: Optimized Surface Specific Interaction Using APTMS and GLYMO Monolayers

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Development of an acetone sensor using nanostructured Co3O4 thin films for exhaled breath analysis

Abstract: We report the fabrication of a breath sensor using nanostructured Co3O4 thin films for the detection of acetone in exhaled breath, which is one of the prominent bio-markers of Diabetic Ketoacidosis (DKA).

Cited by 55 publications

References 66 publications

Recent Trends in Exhaled Breath Diagnosis Using an Artificial Olfactory System

Recent Trends in Exhaled Breath Diagnosis Using an Artificial Olfactory System

Novel Christmas Branched Like NiO/NiWO4/WO3 (p–p–n) Nanowire Heterostructures for Chemical Sensing

SAM Functionalized ZnO Nanowires for Selective Acetone Detection: Optimized Surface Specific Interaction Using APTMS and GLYMO Monolayers

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Product

Resources

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Development of an acetone sensor using nanostructured Co₃O₄ thin films for exhaled breath analysis

Novel Christmas Branched Like NiO/NiWO₄/WO₃ (p–p–n) Nanowire Heterostructures for Chemical Sensing