Development of an adhesive tablet for the delivery of Diospyros villosa root for the treatment of oral cavity diseases

Ribeiro, Adriana; Serrano, Rita; da Silva, Isabel B.Moreira; Pinto, João F.; Silva, Olga

doi:10.1016/j.jddst.2023.105148

Journal of Drug Delivery Science and Technology

2023

DOI: 10.1016/j.jddst.2023.105148

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Development of an adhesive tablet for the delivery of Diospyros villosa root for the treatment of oral cavity diseases

Adriana Ribeiro,

Rita Serrano,

Isabel B.Moreira da Silva

et al.

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2024

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Polyelectrolytes and Polyelectrolyte Complexes as Future Antibacterial Agents

Alsayyed,

Ribeiro,

Cabral-Marques

2024

Bacteria

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Antibiotic-resistance (ABR) poses a critical public health challenge within the broader antimicrobial resistance crisis. This review evaluates the potential of polyelectrolytes (PEs) and polyelectrolyte complexes (PECs) for controlled antibiotic delivery as a strategy to combat ABR and biofilm-related infections. PECs, particularly those incorporating chitosan and other polycations, enhance antibacterial efficacy by disrupting bacterial cell walls and obstructing their nutrient flow. They are also effective in penetrating biofilms and providing sustained drug release. Despite these advantages, there is a need for further in vivo research and clinical trials to validate these findings. This review provides a comprehensive overview of PECs’ potential to advance antibacterial therapies and outlines future research directions to further explore their applications.

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Polyelectrolytes and Polyelectrolyte Complexes as Future Antibacterial Agents

Alsayyed,

Ribeiro,

Cabral-Marques

2024

Bacteria

View full text Add to dashboard Cite

show abstract

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Development of an adhesive tablet for the delivery of Diospyros villosa root for the treatment of oral cavity diseases

Cited by 1 publication

References 38 publications

Polyelectrolytes and Polyelectrolyte Complexes as Future Antibacterial Agents

Polyelectrolytes and Polyelectrolyte Complexes as Future Antibacterial Agents

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