Development of an analytical method for polycyclic aromatic hydrocarbons in coffee beverages and dark beer using novel high-sensitivity technique of supercritical fluid chromatography/mass spectrometry

Yoshioka, Toshiaki; Nagatomi, Yasushi; Harayama, Koichi; Bamba, Takeshi

doi:10.1016/j.jbiosc.2018.01.014

Cited by 40 publications

(18 citation statements)

References 30 publications

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“…As mentioned in the introduction, extraction and pre‐concentration of aromatic hydrocarbon compounds from soil samples have been carried out employing Soxhlet extraction, matrix solid‐phase dispersion, MAE, ultrasonic and mechanical agitation, QuEChERS method and pressurized and supercritical fluid extraction . Despite of PHAs analysis been traditionally carried out by GC–MS, recently SFC–MS has also been used to separate them . An enhanced extraction and identification by SFE‐SFC‐MS has been proposed by Wicker and co‐workers for the first time, in order to avoid extensive sample preparation.…”

Section: On‐line Sfe Coupled To Sfcmentioning

confidence: 99%

“…As mentioned in the introduction, extraction and pre-concentration of aromatic hydrocarbon compounds from soil samples have been carried out employing Soxhlet extraction, matrix solid-phase dispersion, MAE, ultrasonic and mechanical agitation, QuEChERS method and pressurized and supercritical fluid extraction [29]. Despite of PHAs analysis been traditionally carried out by GC-MS, recently SFC-MS has also been used to separate them [73]. An enhanced extraction and identification by SFE-SFC-MS (1) naphthalene, (2) acenaphthylene, (3) acenaphthene, (4) fluorene, (5) phenanthrene, (6) anthracene, (7) fluoranthene, (8) pyrene, (9) benzo(a)anthracene, (10) chrysene, (11) benzo(b) fluoranthene, (12) benzo(k)fluoranthene, (13) benzo(a)pyrene, (14) dibenzo(a,h)anthracene, (15) indeno(1,2,3-cd)pyrene, (16) benzo(g,h,i)perylene.…”

Section: Soil Samplesmentioning

confidence: 99%

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Recent applications of on‐line supercritical fluid extraction coupled to advanced analytical techniques for compounds extraction and identification

Sánchez‐Camargo

Parada-Alonso

Ibáñez

2018

J of Separation Science

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In a previous review (Sánchez-Camargo et al., J. Sep. Sci. 40 (2017) 213-227), we discussed the application of on-line supercritical fluid extraction coupled to chromatographic techniques. This review includes an update of the most recent publications (from January 2016 till June 2018) on this topic, which employs advanced analytical techniques for extracting and identifying valuable analytes. Supercritical fluid extraction has been widely recognized as a green sample preparation technique, because it is efficient, environmentally friendly, powerful, and faster, offering the possibility of direct coupling to analytical instrumental techniques. Among those techniques, supercritical fluid chromatography has experienced an innovative progression in the last 10 years, and the most recent applications of supercritical fluid extraction are coupled to this advanced analytical tool. The general principles, both methodological and instrumental of on-line supercritical fluid extraction coupled to supercritical fluid chromatography are described here. Besides, applications of the mentioned coupling for analysing biological fluids, food, soil, and botanical samples are also presented and discussed. Finally, a brief description about the very recent on-line coupling of supercritical fluid extraction to ion mobility spectrometry is presented, as well as concluding remarks about the importance of using these coupled techniques in the near future.

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Section: On‐line Sfe Coupled To Sfcmentioning

confidence: 99%

Section: Soil Samplesmentioning

confidence: 99%

Recent applications of on‐line supercritical fluid extraction coupled to advanced analytical techniques for compounds extraction and identification

Sánchez‐Camargo

Parada-Alonso

Ibáñez

2018

J of Separation Science

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“…Indeed, these extraction strategies have resulted in higher hit leads during drug discovery [ 12 , 38 , 39 , 40 ]. Innovative extraction technologies including semi-bionic extraction [ 41 ], supercritical fluid extraction [ 42 , 43 , 44 ], microwave-assisted, ultrasonic-assisted and enzyme-assisted extraction [ 45 ], molecular distillation methods [ 46 , 47 ] and membrane separation technology [ 48 , 49 ] can be used to extract natural compounds efficiently from plants. These extractions strategies have been shown to have similar simulation to traditional methods allowing the extraction process to get most compounds from the natural product.…”

Section: Introductionmentioning

confidence: 99%

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

Thomford

Senthebane

Rowe

et al. 2018

IJMS

920

556

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The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant extracts without isolation of active compounds. Modern medicine however, requires the isolation and purification of one or two active compounds. There are however a lot of global health challenges with diseases such as cancer, degenerative diseases, HIV/AIDS and diabetes, of which modern medicine is struggling to provide cures. Many times the isolation of “active compound” has made the compound ineffective. Drug discovery is a multidimensional problem requiring several parameters of both natural and synthetic compounds such as safety, pharmacokinetics and efficacy to be evaluated during drug candidate selection. The advent of latest technologies that enhance drug design hypotheses such as Artificial Intelligence, the use of ‘organ-on chip’ and microfluidics technologies, means that automation has become part of drug discovery. This has resulted in increased speed in drug discovery and evaluation of the safety, pharmacokinetics and efficacy of candidate compounds whilst allowing novel ways of drug design and synthesis based on natural compounds. Recent advances in analytical and computational techniques have opened new avenues to process complex natural products and to use their structures to derive new and innovative drugs. Indeed, we are in the era of computational molecular design, as applied to natural products. Predictive computational softwares have contributed to the discovery of molecular targets of natural products and their derivatives. In future the use of quantum computing, computational softwares and databases in modelling molecular interactions and predicting features and parameters needed for drug development, such as pharmacokinetic and pharmacodynamics, will result in few false positive leads in drug development. This review discusses plant-based natural product drug discovery and how innovative technologies play a role in next-generation drug discovery.

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“…These mostly constitute compounds belonging to secondary metabolic pathways with prominent examples including taxol from Taxus brevifolia, vinblastine from Catharanthus roseus, doxorubicin from Streptomyces peucetius, and cyclosporine from Tolypocladium inflatum [3,4]. The first step in the discovery of lead compounds from natural sources is the release of bioactive metabolites from their biomass through various extraction techniques viz., supercritical fluid extraction [5,6], microwave-assisted and ultrasonic-assisted extraction [7], molecular distillation methods [8], and membrane separation technology [9]. Moreover, bioassay-guided fractionation using chromatographic methods such as preparative high performance liquid chromatography (HPLC) is applied for the isolation and purification of active metabolites from their crude extracts [10].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis

et al. 2020

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Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be represented by synergism between several metabolites. However, isolating every single compound from a natural extract is not always possible due to the complex chemistry and presence of most secondary metabolites at very low levels. Metabolomics has emerged in recent years as an indispensable tool for the analysis of thousands of metabolites from crude natural extracts, leading to a paradigm shift in natural products drug research. Analytical methods such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) are used to comprehensively annotate the constituents of plant natural products for screening, drug discovery as well as for quality control purposes such as those required for phytomedicine. In this review, the current advancements in plant sample preparation, sample measurements, and data analysis are presented alongside a few case studies of the successful applications of these processes in plant natural product drug discovery.

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Development of an analytical method for polycyclic aromatic hydrocarbons in coffee beverages and dark beer using novel high-sensitivity technique of supercritical fluid chromatography/mass spectrometry

Cited by 40 publications

References 30 publications

Recent applications of on‐line supercritical fluid extraction coupled to advanced analytical techniques for compounds extraction and identification

Recent applications of on‐line supercritical fluid extraction coupled to advanced analytical techniques for compounds extraction and identification

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis

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