Development of an enteric nanoparticle of marine sulfated polysaccharide propylene glycol alginate sodium sulfate for oral administration: formulation design, pharmacokinetics and efficacy

Abstract

The study showed that enteric-coated formulation of PSS had the intestinal-targeted absorption and improved pharmacodynamics, which indicated that enteric PSS-NP could be developed into a new formulation product in the future.

Marine Carbohydrate-Based Compounds with Medicinal Properties

“…Faced with this challenge, Li et al tested a new formulation of PSS in the form of enteric-coated nanoparticle (enteric PSS-NP) [107]. The study showed that the PSS nanoparticle had targeted intestinal absorption and improved pharmacodynamics.…”

Marine Carbohydrate-Based Compounds with Medicinal Properties

“…More recent studies have sought a way to improve the bioavailability and efficacy of PSS in the body, since the absorption of this compound can sometimes be impaired because of its high MW. Faced with this challenge, Li et al tested a new formulation of PSS in the form of enteric-coated nanoparticle (enteric PSS-NP) [ 107 ]. The study showed that the PSS nanoparticle had targeted intestinal absorption and improved pharmacodynamics.…”

“…When compared to the PSS solution, enteric PSS-NP had an improved effectiveness in controlling body weight. These data indicate that enteric PSS-NP could be promising in terms of product development in the future [ 107 ].…”

iRGD Tumor-Penetrating Peptide-Modified Nano-Delivery System Based on a Marine Sulfated Polysaccharide for Enhanced Anti-Tumor Efficiency Against Breast Cancer

“…Propylene glycol alginate sodium sulfate (PSS) is a marine sulfated polysaccharide derivative that is used to prevent and treat ischemic cardio-cerebrovascular diseases and hyperlipidemia in China for almost 30 years. [6][7][8] Several studies have reported that PSS can inhibit cancer cell metastasis in vitro through inhibition of angiogenesis and platelet activation. 6,9 Accumulating evidence suggests that PSS is an ideal carrier material for selective loading or efficient co-loading of small molecules and even nanoparticles due to its favorable physical and chemical properties.…”

“…[6][7][8] Several studies have reported that PSS can inhibit cancer cell metastasis in vitro through inhibition of angiogenesis and platelet activation. 6,9 Accumulating evidence suggests that PSS is an ideal carrier material for selective loading or efficient co-loading of small molecules and even nanoparticles due to its favorable physical and chemical properties. 10 However, a critical obstacle of cancer treatment is the inefficient delivery of therapeutic agents due to the high spatiotemporally heterogeneous in the complicated and dense tumor stroma.…”