Development of an extraction and purification method for the determination of multi-class pharmaceuticals and endocrine disruptors in freshwater invertebrates

Huerta, Belinda; Jakimska, A.; Llorca, Marta; Ruhí, Albert; Margoutidis, Georgios; Acuña, Vicenç; Sabater, Sergi; Rodríguez-Mozaz, Sara; Barceló, Damià

doi:10.1016/j.talanta.2014.09.017

Cited by 80 publications

(38 citation statements)

References 64 publications

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“…Macroinvertebrates were processed following Huerta et al (2015). Samples (100 mg, dry weight) were extracted with an ultrasonic probe (Branson Digital Sonifier, model 102C) (120 s, 3 cycles, 30% amplitude) and homogenized in 3 mL of methanol.…”

Section: Emerging Contaminant Extractionmentioning

confidence: 99%

Bioaccumulation and trophic magnification of pharmaceuticals and endocrine disruptors in a Mediterranean river food web

Ruhí

Acuña

Barceló

et al. 2016

Science of The Total Environment

150

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Section: Emerging Contaminant Extractionmentioning

confidence: 99%

Bioaccumulation and trophic magnification of pharmaceuticals and endocrine disruptors in a Mediterranean river food web

Ruhí

Acuña

Barceló

et al. 2016

Science of The Total Environment

150

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“…Therefore, these are included in the endocrine disrupting compounds (EDCs) group. Natural attenuation and conventional treatment processes are not capable of removing these micropollutants from wastewater and surface and drinking water and are reported to bioaccummulate in macro invertebrates, other organisms in the aquatic food web and humans [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Treatment technologies for emerging contaminants in water: A review

Rodríguez-Narváez

Peralta‐Hernández

Goonetilleke

et al. 2017

Chemical Engineering Journal

982

287

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“…Various sample preparation processes have been employed to extract pharmaceuticals and metabolites from invertebrates, such as liquid-liquid extraction, pulverised liquid extraction, and sonication [25,[27][28][29]. Although these methods can successfully extract PPCPs from the samples, they need to be carefully optimised in order to achieve adequate recovery.…”

Section: Introductionmentioning

confidence: 99%

Determination of selected emerging contaminants in freshwater invertebrates using a universal extraction technique and liquid chromatography accurate mass spectrometry

Althakafy

Kulsing

Grace

et al. 2018

J of Separation Science

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A simple sample preparation method based on a modified liquid-phase extraction approach to extract selected pharmaceuticals and personal care products from freshwater organisms is described. Extracted samples were analysed using liquid chromatography with Q-Exactive plus hybrid quadrupole Orbitrap mass spectrometry, using 2.6 μm C18 media. A 0.1% v/v acetic acid/acetonitrile mobile phase was applied over a 20 min gradient. Method detection limits in full scan mode were ca. 0.04-2.38 ng of analyte per g of sample. Linearity ranged from 0.9750 to 0.9996 over the calibration range of 0.01-100 μg/L; MS mass accuracy was <2 ppm for most analytes. This method was applied to quantify six pharmaceuticals and personal care products in seven invertebrate samples. For tandem mass spectrometry analysis, selection of precursor ions was performed for each pharmaceutical, with Mass Frontier software illustrating the fragmentation mechanism. Effects of collision energy on intensities of ions was further investigated. The tandem mass spectrometry condition resulting in the highest signal of respective selected product ion was selected to confirm each pharmaceutical, which was initially observed in the full scan mode. Results indicate that pharmaceuticals and personal care products found to be present in water-ways, may be incorporated into organisms that live in the environment of affected water streams.

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Development of an extraction and purification method for the determination of multi-class pharmaceuticals and endocrine disruptors in freshwater invertebrates

Cited by 80 publications

References 64 publications

Bioaccumulation and trophic magnification of pharmaceuticals and endocrine disruptors in a Mediterranean river food web

Bioaccumulation and trophic magnification of pharmaceuticals and endocrine disruptors in a Mediterranean river food web

Treatment technologies for emerging contaminants in water: A review

Determination of selected emerging contaminants in freshwater invertebrates using a universal extraction technique and liquid chromatography accurate mass spectrometry

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