Development of an Immunoaffinity Chromatography Purification and Ultra Performance Liquid Chromatography Tandem Mass Spectrometry Method for Determination of 12 Sulfonamides in Beef and Milk

Zhao, Xiaotian; Lin, Qin‐Bao; Huan, Song; Pan, Ya-Li; Wang, Xiong

doi:10.1021/jf202705d

Cited by 18 publications

(10 citation statements)

References 29 publications

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“…Additionally, there are specific applications in which very low abundant and low molecular weight analytes are present in complex matrices, usually biological matrices that need to be previously fractionated to allow the trace enrichment of the target analytes. For example, Xu et al [109] recently described the use of RAM-MIPs followed by HPLC-UV detection of sulfonamides in bovine milk, allowing them to obtain the same analytical performance of reference methods using LC-MS/MS detection [110,111]. RAM (restricted access materials) are generic materials that can fractionate a biological sample into its protein matrix and analyte fraction by means of a molecular-weight cutoff mechanism.…”

Section: Recent Trends and Applicationsmentioning

confidence: 99%

Microextraction using packed sorbent as an effective and high-throughput sample extraction technique: Recent applications and future trends.

Gonçalves¹,

Alves²,

Câmara³

2013

Sample Preparation

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In the last decade, several developments, particularly in the liquid chromatography and hyphenated techniques fields, have allowed researchers to reach analytical limits that are becoming very close to the single molecule level. Sample preparation, however, despite being a key step in the analytical methodology, did not track these developments and very few approaches able to cope with these stringent analytical requirements were developed. One such approach is microextraction by packed sorbent (MEPS), a sophisticated and miniaturized form of solid phase extraction that has reduced to the microliter scale every step of the sample extraction methodology including sample volume and solvent usage. Simultaneously, the amount of extraction phase used was also reduced and, more importantly, the sorbent is reusable dozens of times which significantly lowers the cost of analysis versus other solid-phase extraction approaches. In this review, we will update the state-of-the-art of the MEPS technique, focusing on the trends and applications reported since 2010 and future perspectives and developments that in our view will further improve the high-throughput potential and applications of this sample preparation methodology. KeywordsMicroextraction by packed sorbent (MEPS) • eVol • Sample preparation • Solid phase extraction (SPE) © 2013 J. Pereira et al., licensee Versita Sp. z o. o. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs license, which means that the text may be used for non-commercial purposes, provided credit is given to the author Unauthenticated Download Date | 12/26/14 1:57 PM Microextraction using packed sorbent as an effective and high-throughput sample extraction technique: Recent applications and future trends. Unauthenticated Download Date | 12/26/14 1:57 PM J. Pereira et al. 40 Unauthenticated Download Date | 12/26/14 1:57 PM Microextraction using packed sorbent as an effective and high-throughput sample extraction technique: Recent applications and future trends. Unauthenticated Download Date | 12/26/14 1:57 PM Microextraction using packed sorbent as an effective and high-throughput sample extraction technique: Recent applications and future trends.

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Section: Recent Trends and Applicationsmentioning

confidence: 99%

Microextraction using packed sorbent as an effective and high-throughput sample extraction technique: Recent applications and future trends.

Gonçalves¹,

Alves²,

Câmara³

2013

Sample Preparation

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“…The determination of sulfonamides has been carried out mainly using HPLC with UV [3][4][5], fluorescence with previous derivatization using fluorescamine [6][7][8], and MS detectors [9][10][11]. CE has also been proposed for sulfonamides determination in food and water samples [12,13].…”

Section: Introductionmentioning

confidence: 99%

Determination of 19 sulfonamides residues in pork samples by combining QuEChERS with dispersive liquid-liquid microextraction followed by UHPLC-MS/MS

Peng

et al. 2017

J. Sep. Sci.

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A new simple and rapid pretreatment method for simultaneous determination of 19 sulfonamides in pork samples was developed through combining the QuEChERS method with dispersive liquid-liquid microextraction followed by ultra-high performance liquid chromatography with tandem mass spectrometry. The sample preparation involves extraction/partitioning with QuEChERS method followed by dispersive liquid-liquid microextraction using tetrachloroethane as extractive solvent and the acetonitrile extract as dispersive solvent that obtained by QuEChERS. The enriched tetrachloroethane organic phase by dispersive liquid-liquid microextraction was evaporated, reconstituted with 100 μL acetonitrile/water (1:9 v/v) and injected into an ultra-high performance liquid chromatography with a mobile phase composed of acetonitrile and 0.1% v/v formic acid under gradient elution and separated using a BHE C column. Various parameters affecting the extraction efficiency were investigated. Matrix-matched calibration curves were established. Good linear relationships were obtained for all analytes in a range of 2.0-100 μg/kg and the limits of detection were 0.04-0.49 μg/kg. Average recoveries at three spiking levels were in the range of 78.3-106.1% with relative standard deviations less than 12.7% (n = 6). The developed method was successfully applied to determine sulfonamide residues in pork samples.

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“…However, the trace amounts of drug residues, complex matrices and the interference of impurities are still the challenges in analysis. To overcome such difficulties, novel pretreatment techniques such as immunoaffinity chromatography (Zhao, Lin, Song, Pan, & Wang, 2011) and molecular imprinting (Siemann, Andersson, & Mosbach, 1997) have been introduced in the selective retention of drugs and the powerful elimination of impurities.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted solid-phase extraction for the determination of ten macrolide drugs residues in animal muscles by liquid chromatography–tandem mass spectrometry

et al. 2016

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A simple and sensitive method based on molecularly imprinted solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry was developed for the determination of the residues of ten macrolide drugs in swine, cattle and chicken muscles samples. The molecularly imprinted polymers (MIPs) were synthesized using tylosin as a template and methacrylic acid as a functional monomer. Samples were extracted with sodium borate buffer solution and ethyl acetate, and purified by the MIP cartridge. The results showed that the cartridge exhibited good recognition performance for macrolides, and better purification effect than the traditional solid-phase extraction cartridges. Recoveries of analytes at three spiking levels 1, 5 and 20μgkg(-1) ranged from 60.7% to 100.3% with the relative standard deviations less than 14%. The limits of detection of the method were between 0.1 and 0.4μgkg(-1). The method is useful for the routine monitoring of the residues of macrolide drugs in animal muscles.

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Development of an Immunoaffinity Chromatography Purification and Ultra Performance Liquid Chromatography Tandem Mass Spectrometry Method for Determination of 12 Sulfonamides in Beef and Milk

Cited by 18 publications

References 29 publications

Microextraction using packed sorbent as an effective and high-throughput sample extraction technique: Recent applications and future trends.

Microextraction using packed sorbent as an effective and high-throughput sample extraction technique: Recent applications and future trends.

Determination of 19 sulfonamides residues in pork samples by combining QuEChERS with dispersive liquid-liquid microextraction followed by UHPLC-MS/MS

Molecularly imprinted solid-phase extraction for the determination of ten macrolide drugs residues in animal muscles by liquid chromatography–tandem mass spectrometry

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