Development of an SPE Method Using Ionic Liquid-Based Monolithic Column for On-Line Cleanup of Human Plasma and Simultaneous Determination of Five Steroid Drugs

Pang, Xiaomin; Bai, Ligai; Lan, Dandan; Guo, Bin; Wang, Huimin; Liu, Haiyan; Ma, Zhengyue

doi:10.1007/s10337-018-3579-0

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…The range of sorbents for SPE varies from graphitized carbon to chemically bonded C8, and C18 silica, and different kinds of polymeric material among others [26,27]. Although SPE has many advantages, it also has some demerits such as its high cost and batchto-batch variation that affects reproducibility [28][29][30].…”

Section: Solid-phase Extraction (Spe)mentioning

confidence: 99%

Estimation of Steroid Hormones in Biological Samples Using Micro Extraction and Advanced Chromatography Techniques

Srivastava¹,

Godbole²,

Shrivastava³

2022

austinjanalpharmchem

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Steroid profiling plays an important role in the clinical setting and also in the diagnosis of various physiological disorders. Steroids in the research laboratory and patient care has been routinely measured by immunoassay. Limitations of immunoassay in quantifying steroids have been well documented and the advent of advanced mass spectrometry is offering a viable alternative to measure multiple steroids in single reaction. Analytes ranging from the steroid and their metabolites that are present in the body carry out various important functions and are relevant to maintaining homeostasis. Blood plasma and urine samples are the clinical material for such analysis, however, due to the difference in polarity of the target steroid, a major challenge exists as to how faithfully analyze different steroids in the given sample type. These steroids are usually present at very low concentrations in the body and are present in several forms leading to increased complexity. Achieving an excellent chromatographic separation for the analysis of steroids requires an effective sample preparation and analysis procedure. Hence various methods are developed to analyze the presence of steroids and to know their exact concentration in the body. This review covers various analytical methodologies such as chromatographic procedures and downstream mass spectrometry for the identification and measurement of the levels of steroid hormones. At the same time, this review also covers the most recent developments that have taken place in the recent past to cover the enhanced understanding of steroid hormone analysis.

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Section: Solid-phase Extraction (Spe)mentioning

confidence: 99%

Estimation of Steroid Hormones in Biological Samples Using Micro Extraction and Advanced Chromatography Techniques

Srivastava¹,

Godbole²,

Shrivastava³

2022

austinjanalpharmchem

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“…Pang et al [116] fabricated a polymer monolith column with 1-vinyl-3-hexylimidazolium bromide ([ViC 6 MIM][Br]) IL which was used for the on-line SPE isolation of betamethasone, norgestrel, halcinonide, beclomethasone dipropionate and testosterone propionate from human plasma. The developed SPE-HPLC-UV method offered the effective extraction of the analytes (93-105%), which allowed the target compounds to be quantified with LODs of 1-2 ng/mL.…”

Section: Biological Samplesmentioning

confidence: 99%

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

et al. 2020

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Recent years have seen the increased utilization of ionic liquids (ILs) in the development and optimization of analytical methods. Their unique and eco-friendly properties and the ability to modify their structure allows them to be useful both at the sample preparation stage and at the separation stage of the analytes. The use of ILs for the analysis of pharmaceuticals seems particularly interesting because of their systematic delivery to the environment. Nowadays, they are commonly detected in many countries at very low concentration levels. However, due to their specific physiological activity, pharmaceuticals are responsible for bioaccumulation and toxic effects in aquatic and terrestrial ecosystems as well as possibly upsetting the body’s equilibrium, leading to the dangerous phenomenon of drug resistance. This review will provide a comprehensive summary of the use of ILs in various sample preparation procedures and separation methods for the determination of pharmaceuticals in environmental and biological matrices based on liquid-based chromatography (LC, SFC, TLC), gas chromatography (GC) and electromigration techniques (e.g., capillary electrophoresis (CE)). Moreover, the advantages and disadvantages of ILs, which can appear during extraction and separation, will be presented and attention will be given to the criteria to be followed during the selection of ILs for specific applications.

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“…The optimized method extracted nifedipine, nitrendipine, and felodipine spiked in human plasma from patients that previously ingested nifedipine and nitrendipine tablets. In another application, Pang et al used a similar PIL-monolithic column for the determination of steroid drugs in plasma . The monolith was based on the use of the 1-vinyl-3-hexylimidazolium bromide ([VC 6 IM + ][Br – ]) IL as functional monomer with ethylenedimethyl acrylate and trimethylolpropane triacrylate as cross-linkers.…”

Section: Sample Preparationmentioning

confidence: 99%

“…In another application, Pang et al used a similar PIL-monolithic column for the determination of steroid drugs in plasma. 30 The monolith was based on the use of the 1vinyl-3-hexylimidazolium bromide ([VC 6 IM + ][Br − ]) IL as functional monomer with ethylenedimethyl acrylate and trimethylolpropane triacrylate as cross-linkers.…”

mentioning

confidence: 99%

Advances of Ionic Liquids in Analytical Chemistry

et al. 2018

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Development of an SPE Method Using Ionic Liquid-Based Monolithic Column for On-Line Cleanup of Human Plasma and Simultaneous Determination of Five Steroid Drugs

Cited by 6 publications

References 30 publications

Estimation of Steroid Hormones in Biological Samples Using Micro Extraction and Advanced Chromatography Techniques

Estimation of Steroid Hormones in Biological Samples Using Micro Extraction and Advanced Chromatography Techniques

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples—Trends and Perspectives

Advances of Ionic Liquids in Analytical Chemistry

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