Development of aptamer-modified SERS nanosensor and oligonucleotide chip to quantitatively detect melamine in milk with high sensitivity

Dong, Ning; Hu, Yongjun; Kang, Yang; Liu, Jianzhi

doi:10.1016/j.snb.2015.12.089

Cited by 52 publications

(19 citation statements)

References 51 publications

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“…It should be noted that quantitative and ultrasensitive detection of melamine has been carried out in recent years. [10][11][12][13][14][15] The fabrication of SERS-active substrates usually uses the assembly method, and the prepared substrates can achieve high sensitivity in SERS measurements, even down to the 1 ppb level. 10 However, the assembly method is timeconsuming and it is difficult to precisely control the gaps between adjacent nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Bioscaffold arrays decorated with Ag nanoparticles as a SERS substrate for direct detection of melamine in infant formula

Zhao

Tian

et al. 2019

RSC Adv.

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Three-dimensional (3D) plasmonic structures have been intensively investigated as high performance surface enhanced Raman scattering (SERS) substrates. Here, we demonstrate a 3D biomimetic SERS substrate prepared by deposition of silver nanoparticles (Ag NPs) on the bioscaffold arrays of cicada wings using laser molecular beam epitaxy. This deposition method can offer a large number of nanoparticles with average diameter of $10 nm and nanogaps of sub-10 nm on the surface of chitin nanopillars to generate a high density of hotspots. The prepared 3D Ag/cicada SERS substrate shows a limit of detection (LOD) for Rhodamine 6G as low as 10 À7 M, high enhancement factor of 1.09 Â 10 5 , and excellent signal uniformity of 6.8%. Moreover, the molecular fingerprints of melamine in infant formula can be directly extracted with an LOD as low as 10 mg L À1 , without the need for functional modification. The prepared SERS-active substrate, due to its low cost, high-throughput, and good detection performance, can be widely used in applications such as food safety and environmental monitoring.

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Section: Introductionmentioning

confidence: 99%

Bioscaffold arrays decorated with Ag nanoparticles as a SERS substrate for direct detection of melamine in infant formula

Zhao

Tian

et al. 2019

RSC Adv.

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“…This will lead to an increase in the absorbance. 53 No matter whether DNA (S1) was attached to AuNPs, SERS spectrum shows that only the characteristic peak of 2-NT was observed, as shown in Fig. S3 (Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Sensitive and Selective Detection of Mercury Ions in Aqueous Media Using an Oligonucleotide-functionalized Nanosensor and SERS Chip

Zou

Xue

et al. 2018

ANAL. SCI.

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A surface-enhanced Raman scattering (SERS) platform for the selective trace analysis of Hg 2+ ions was reported, based on poly-thymine (T) aptamer/2-naphthalenethiol (2-NT)-modified gold nanoparticles (AuNPs), which was an oligonucleotide-functionalized nanosensor and SERS chip. 2-NT was used as a Raman reporter, and T aptamer could form a T-Hg 2+ -T structure with Hg 2+ ions making an SERS nanosensor absorbed to the SERS chip. The optimum concentrations of DNA and 2-NT were obtained. An average of 960 DNA molecules attached to each AuNP were measured. The limit of detection (LOD) was 1.0 ppt (1.0 × 10 -12 g/mL), which is far below the limit of 10.0 ppb for drinking water, stipulated by the World Health Organization. The sensor has the advantages of low detection cost, a simple sample pretreatment, a green solution and reducing false positives. Furthermore, the nanosensor was used for the determination of trace Hg 2+ in the water of a lake; a reliable result was obtained accurately.

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“…The above tactic permits the on-site broadcast of melamine in food products. In a similar fashion, Dong et al developed an aptamer-modified SERS nanosensor and oligonucleotide chip to quantify the melamine via multi-hydrogen-bond formation between thymine and melamine [151]. This method showed a LOD at picogram level, and hence such design is highly desirable.…”

Section: Nanoparticles In Melamine Quantificationmentioning

confidence: 99%

“…Besides, SERS-based detection of melamine has also been authenticated as a more efficient tactic. Many researchers reported the functionalized or label free or bare Au NPs towards the discrimination of melamine through SERS studies [125,133,141,151,157,[160][161][162][163]166]. Many of them revealed great applicability with exceptional LODs.…”

Section: Nanoparticles In Melamine Quantificationmentioning

confidence: 99%

Review on Nanomaterial-Based Melamine Detection

Shellaiah

Sun

2019

Chemosensors

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Illegal adulteration of milk products by melamine and its analogs has become a threat to the world. In 2008, the misuse of melamine with infant formula caused serious effects on babies of China. Thereafter, the government of China and the US Food and Drug Administration (FDA) limited the use of melamine of 1 mg/kg for infant formula and 2.5 mg/kg for other dairy products. Similarly, the World Health Organization (WHO) has also limited the daily intake of melamine of 0.2 mg/kg body weight per day. Many sensory schemes have been proposed by the scientists for carrying out screening on melamine poisoning. Among them, nanomaterial-based sensing techniques are very promising in terms of real-time applicability. These materials uncover and quantify the melamine by means of diverse mechanisms, such as fluorescence resonance energy transfer (FRET), aggregation, inner filter effect, surface-enhanced Raman scattering (SERS), and self-assembly, etc. Nanomaterials used for the melamine determination include carbon dots, quantum dots, nanocomposites, nanocrystals, nanoclusters, nanoparticles, nanorods, nanowires, and nanotubes. In this review, we summarize and comment on the melamine sensing abilities of these nanomaterials for their suitability and future research directions.

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Development of aptamer-modified SERS nanosensor and oligonucleotide chip to quantitatively detect melamine in milk with high sensitivity

Cited by 52 publications

References 51 publications

Bioscaffold arrays decorated with Ag nanoparticles as a SERS substrate for direct detection of melamine in infant formula

Bioscaffold arrays decorated with Ag nanoparticles as a SERS substrate for direct detection of melamine in infant formula

Sensitive and Selective Detection of Mercury Ions in Aqueous Media Using an Oligonucleotide-functionalized Nanosensor and SERS Chip

Review on Nanomaterial-Based Melamine Detection

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