Development of Biopolymer Based Matrix Type Multiple Unit Systems for Sustained Release of Diclofenac Sodium:<i>In vitro</i>and<i>In vivo</i>Evaluation

Ashok, Thadisetty; Naidu, K. V. S.; Vooturi, Rajesh; Mohan, Eaga Chandra; Rao, Yi

doi:10.1080/10601320701842308

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Due to its remarkable combination of properties, chitosan has found a number of applications in drug delivery including that of an absorption enhancer for hydrophilic macromolecular drugs, as promising polymeric excipients for mucosal drug and vaccine delivery [3], and as a gene delivery system [4]. Moreover, chitosan has antacid and antiulcer activities, which can prevent or weaken drug induces irritation in the stomach [5]. These interesting properties make chitosan an ideal candidate for controlled drug release formulations.…”

Section: Introductionmentioning

confidence: 98%

Development and characterization of chitosan and phosphomolybdic acid (PMA) based composites

Mishra

Mondal

Datt

et al. 2010

Int J Plast Technol

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This work reports the development and characterization of chitosan/Phosphomolybdic acid (PMA) based composite membranes. The prepared composite membranes were characterized by FTIR (Fourier transform infrared) spectroscopy, X ray diffraction (XRD), differential scanning calorimetry (DSC), tensile strength test, and thermogravimetric analysis (TGA). FTIR spectroscopy indicated the proper molecular interactions between chitosan and PMA. XRD spectroscopy indicated the semi crystalline nature of the composite membranes. DSC study showed the presence of single glass transition temperature (Tg) at 156°C in the 20% PMA doped membrane, which indicates the miscible nature of chitosan and PMA blend. TGA study indicates increase in thermal stability of the composite membranes as compared to pure chitosan. Mechanical properties of the

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Section: Introductionmentioning

confidence: 98%

Development and characterization of chitosan and phosphomolybdic acid (PMA) based composites

Mishra

Mondal

Datt

et al. 2010

Int J Plast Technol

View full text Add to dashboard Cite

show abstract

“…Moreover, chitosan has antacid and antiulcer activities, which can prevent or weaken drug-induced irritation in the stomach [5]. These interesting properties make chitosan an ideal candidate for controlled drug release formulations.…”

Section: Introductionmentioning

confidence: 99%

Development and Material Properties of Chitosan and Phosphomolybdic Acid-based Composites

Bhat

Khalil

et al. 2010

Journal of Composite Materials

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This work reports the development and characterization of chitosan/ phosphomolybdic acid-based composite membranes. The prepared composite membranes were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), tensile strength test, and thermogravimetric analysis (TGA). FTIR spectroscopy indicated the proper molecular interactions between chitosan and PMA. XRD spectroscopy indicated the semi crystalline nature of the composite membranes. DSC study showed the presence of single glass transition temperature (T g ) at 156 C in the 20% PMA-doped membrane, which indicates the miscible nature of chitosan and PMA blend. TGA study indicates increase in thermal stability of the composite membranes as compared to pure chitosan. Mechanical properties of the composite membranes were found to be enhanced significantly.

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“…Chitosan has desirable biological properties, being biodegradable and bioabsorbale [7] and having gel-forming ability at low pH. Due to its remarkable combination of properties, chitosan has found a number of applications in drug delivery including that of an absorption enhancer for hydrophilic macromolecular drugs, as promising polymeric excipients for mucosal drug and vaccine delivery [8], and as a gene delivery system [9]. Moreover, chitosan has antacid and antiulcer activities, which can prevent or weaken drug induces irritation in the stomach [10].…”

mentioning

confidence: 99%

Fabrication and characterization of Chitosan/Poly (vinyl alcohol)-co-(vinyl acetate)-co-(itaconic acid) hydrogel membranes

Mishra

Majeed

Banthia

2011

Int J Plast Technol

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A pH sensitive hydrogel was developed by freeze thaw method based on chitosan and Poly (vinyl alcohol)-co-(vinyl acetate)-co-(itaconic acid) (PVACO). The hydrogel membranes were characterized by FTIR (Fourier transform infrared) spectroscopy, X ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The mechanical properties of the blend membranes were evaluated by tensile strength test. FTIR spectral characterization showed probable molecular interactions between the natural and synthetic polymer. The swelling investigation indicated that hydrogels were highly sensitive to pH of the surrounding environment. The swelling ratios of the gels in stimulated gastric fluid (SGF, pH 1.4) were higher than those in stimulated intestinal fluids (SIF, pH 7.4). The SEM analysis of the freeze dried hydrogels reveals highly porous morphology of blend hydrogels with uniformly arranged pores of 20-100 μm size and it was found that porosity eventually increases with increasing ratio of chitosan in the prepared hydrogels. Mechanical properties were found to be sufficient in all the developed membranes.

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Development of Biopolymer Based Matrix Type Multiple Unit Systems for Sustained Release of Diclofenac Sodium:In vitroandIn vivoEvaluation

Cited by 4 publications

References 31 publications

Development and characterization of chitosan and phosphomolybdic acid (PMA) based composites

Development and characterization of chitosan and phosphomolybdic acid (PMA) based composites

Development and Material Properties of Chitosan and Phosphomolybdic Acid-based Composites

Fabrication and characterization of Chitosan/Poly (vinyl alcohol)-co-(vinyl acetate)-co-(itaconic acid) hydrogel membranes

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