Development of buccal tablets for curcumin using Anacardium occidentale gum

A focus on mucoadhesive polymers and their application in buccal dosage forms

“…In vivo studies reported that the formulation containing 5% chitosan showed the following kinetic parameters: maximum C max ¼ 20.1 ± 1.5 ng/mL; AUC ¼ 3842.0 ± 488.9 ng/mL/min; and minimum t max values ¼ 20 min. Bi-layered buccoadhesive devices intended for systemic absorption have been designed and developed to promote drug release unidirectionally on the side in contact to the buccal mucosal surface avoiding the release in the salivary fluids [82,83]. To this aim a mucoadhesive layer, constituted by a single polymer or a blend of mucoadhesive polymers, containing the drug, was impermeabilised by a hydrophobic backing layer.…”

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis

“…In addition to the large surface area of the NFs available to interact with biosurfaces, they can interact with the mucosa after fluid uptake through the presence of numerous nanometer-sized interfibrillar pores causing mucoadhesion. 51 Gowthamarajan et al 52 reported that the mucoadhesive property of polymers was influenced by their swelling nature. The higher water uptake might help in establishing a quicker and stronger interpenetration of polymer chains into the mucous and improved their contact time.…”

Development and Validation of UV-Spectrophotometric method for the Estimation of Curcumin in Standardised Polyherbal Formulations

“…While UV-spectrophotometric methods are more suitable for this objective, studies on dedicated UV-spectrophotometric methods to quantify the curcumin in polyherbal formulations are very limited. 20 Therefore, in the present study, a simple UV method was developed and validated according to international conference harmonization (ICH) guidelines for the quantitative estimation of curcumin in polyherbal formulations. 21 The method has also been tested by using market available Live-well™, CUMIN capsules.…”