Development of cartilage tissue engineering techniques based on biomedical research

Iwasaki, Norimasa

doi:10.1007/s00776-014-0594-3

Cited by 10 publications

(4 citation statements)

References 29 publications

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“…Alginate hydrogels have been previously used for cell encapsulation [210] and for vascular and cartilage regeneration [211,212]. Additionally, alginate can be dissolved in aqueous solutions without the aid of any solvents.…”

Section: Alginate/bioactive Glass Compositesmentioning

confidence: 99%

A Review of Bioactive Glass/Natural Polymer Composites: State of the Art

2020

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Collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose are biocompatible and non-cytotoxic, being attractive natural polymers for medical devices for both soft and hard tissues. However, such natural polymers have low bioactivity and poor mechanical properties, which limit their applications. To tackle these drawbacks, collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose can be combined with bioactive glass (BG) nanoparticles and microparticles to produce composites. The incorporation of BGs improves the mechanical properties of the final system as well as its bioactivity and regenerative potential. Indeed, several studies have demonstrated that polymer/BG composites may improve angiogenesis, neo-vascularization, cells adhesion, and proliferation. This review presents the state of the art and future perspectives of collagen, gelatin, silk fibroin, hyaluronic acid, chitosan, alginate, and cellulose matrices combined with BG particles to develop composites such as scaffolds, injectable fillers, membranes, hydrogels, and coatings. Emphasis is devoted to the biological potentialities of these hybrid systems, which look rather promising toward a wide spectrum of applications.

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Section: Alginate/bioactive Glass Compositesmentioning

confidence: 99%

A Review of Bioactive Glass/Natural Polymer Composites: State of the Art

2020

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“…Despite their wide applications in the bone tissue engineering, their translation to the clinics has not been achieved due to their 2D structure. Accordingly, electrospun nanofibers can be incorporated into the 3D structures as the nanocomposite filler 15 .…”

Section: Introductionmentioning

confidence: 99%

A tailored polylactic acid/polycaprolactone biodegradable and bioactive 3D porous scaffold containing gelatin nanofibers and Taurine for bone regeneration

Samadian

Farzamfar

Vaez

et al. 2020

Sci Rep

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The focus of the current study was to develop a functional and bioactive scaffold through the combination of 3D polylactic acid (PLA)/polycaprolactone (PCL) with gelatin nanofibers (GNFs) and Taurine (Tau) for bone defect regeneration. GNFs were fabricated via electrospinning dispersed in PLA/PCL polymer solution, Tau with different concentrations was added, and the polymer solution converted into a 3D and porous scaffold via the thermally-induced phase separation technique. The characterization results showed that the scaffolds have interconnected pores with the porosity of up to 90%. Moreover, Tau increased the wettability and weight loss rate, while compromised the compressive strengths. The scaffolds were hemo- and cytocompatible and supported cell viability and proliferation. The in vivo studies showed that the defects treated with scaffolds filled with new bone. The computed tomography (CT) imaging and histopathological observation revealed that the PLA/PCL/Gel/Tau 10% provided the highest new bone formation, angiogenesis, and woven bone among the treatment groups. Our finding illustrated that the fabricated scaffold was able to regenerate bone within the defect and can be considered as the effective scaffold for bone tissue engineering application.

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“…ACI is an expensive, two-stage process and it does not address the pathology of the subchondral bone [5]. Cartilage tissue engineering techniques and scaffolds such as ultrapurified alginate (UPAL) gel [29] and platelet-rich fibrin (PRF) may provide future directions for management of elbow OCD [30].…”

Section: Discussionmentioning

confidence: 99%