Development of Cochlear Potentials in Rats

Uziel, Alain; Romand, R.; Marot, Michel

doi:10.3109/00206098109072687

Cited by 182 publications

(106 citation statements)

References 19 publications

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“…The functional significance of PGD synthetase, or of PGD2, in the cochlear hair cells can presently be only a matter of speculation. This study indicates that the PGD synthetase-like immunoreactivity in the hair cells first appears r9 days after birth; in comparison, others have found that cochlear microphonics first occur 8 or 9 days after birth in rats (22,23). The coincidence ofthese two events suggests that PGD2 may be involved in biologically important phenomena in the cochlear hair cells.…”

Section: Discussionsupporting

confidence: 47%

Brain-type prostaglandin D synthetase occurs in the rat cochlea.

Tachibana

Fex

Urade

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionsupporting

confidence: 47%

Brain-type prostaglandin D synthetase occurs in the rat cochlea.

Tachibana

Fex

Urade

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

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“…maturation of sensory systems such as taste, sound, and vision (Smart and Dobbing, 1971;Altman and Sudarshan, 1975;Routtenberg et al, 1978;Uziel et al, 1981;Hill and Mistretta, 1990;Westerga and Gramsbergen, 1990;Vorhees et al, 1994), as well as increased communication and social behavior (Bolles and Woods, 1964;Hofer et al, 1998). However, it was surprising to discover the magnitude and breadth of reorganization of gene expression postpartum, with a given brain region not recognizable as "itself" before 2 weeks of life.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional Profiling of the Developing Rat Brain Reveals That the Most Dramatic Regional Differentiation in Gene Expression Occurs Postpartum

Stead¹,

Neal²,

Meng³

et al. 2006

J. Neurosci.

106

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Neural development involves the expression of ensembles of regulatory genes that control the coordinate and region-specific expression of a host of other genes, resulting in the unique structure, connectivity, and function of each brain region. Although the role of some specific genes in neural development has been studied in detail, we have no global view of the orchestration of spatial and temporal aspects of gene expression across multiple regions of the developing brain. To this end, we used transcriptional profiling to examine expression levels of 9955 genes in the hypothalamus, hippocampus, and frontal cortex across seven stages of postnatal development and up to four stages of prenatal development in individual male rats (six per group). The results reveal dramatic changes across development in Ͼ97% of the neurally expressed genes. They also uncover a surprising degree of regional differentiation occurring after birth and through the first 2 weeks of life. Cluster analysis identifies 20 clusters of transcripts enriched in genes related to particular functions, such as DNA metabolism, nuclear function, synaptic vesicle transport, myelination, and neuropeptide hormone activity. Thus, groups of genes with related functions change in the brain at specific times, possibly marking critical periods for each function. These findings can broadly serve as a backdrop for studying the role of individual genes in neural development. They also underscore the importance of early postnatal life in the rat, which corresponds to late gestation in the human, as a critical late phase of neural organization and differentiation, even in subcortical regions.

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“…At this age, several measures of outer hair cell function have matured, including the cochlear microphonic potential (reflecting outer hair cell transduction) (Uziel et al 1981) and the amplitude of electromotility (Beurg et al 2001). The outer hair cell currents are compared with results from type I hair cells isolated from the sensory epithelium of the rat utricle on P16-P24.…”

Section: Methodsmentioning

confidence: 99%