Development of composite functional tissue sheets using hiPSC-CMs and hADSCs to improve the cardiac function after myocardial infarction

Zhang, Jingbo; Li, Junjun; Qu, Xiang; Liu, Yuting; Sun, Lifu; Harada, Akima; Hua, Ying; Sougawa, Nagako; Tabata, Akiko; Liu, Li; Miyagawa, Shigeru

doi:10.1016/j.bioactmat.2024.03.028

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…The development of scaffold-based therapeutics represents a significant advance in tissue engineering, offering promising strategies for repairing damaged cardiac tissues and restoring their structure and function [135,136]. These scaffolds, derived from both synthetic and natural biomaterials, are crucial in regenerating diverse tissues including bone, cartilage, ligaments, neural tissues, skin, skeletal muscle, and blood vessels [137,138].…”

Section: Scaffold-based Therapeutics: Enhancing Stem Cell Potentialmentioning

confidence: 99%

Emerging Strategies in Mesenchymal Stem Cell-Based Cardiovascular Therapeutics

Kumar,

Mishra,

Tran

et al. 2024

Cells

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Cardiovascular diseases continue to challenge global health, demanding innovative therapeutic solutions. This review delves into the transformative role of mesenchymal stem cells (MSCs) in advancing cardiovascular therapeutics. Beginning with a historical perspective, we trace the development of stem cell research related to cardiovascular diseases, highlighting foundational therapeutic approaches and the evolution of cell-based treatments. Recognizing the inherent challenges of MSC-based cardiovascular therapeutics, which range from understanding the pro-reparative activity of MSCs to tailoring patient-specific treatments, we emphasize the need to refine the pro-regenerative capacity of these cells. Crucially, our focus then shifts to the strategies of the fourth generation of cell-based therapies: leveraging the secretomic prowess of MSCs, particularly the role of extracellular vesicles; integrating biocompatible scaffolds and artificial sheets to amplify MSCs’ potential; adopting three-dimensional ex vivo propagation tailored to specific tissue niches; harnessing the promise of genetic modifications for targeted tissue repair; and institutionalizing good manufacturing practice protocols to ensure therapeutic safety and efficacy. We conclude with reflections on these advancements, envisaging a future landscape redefined by MSCs in cardiovascular regeneration. This review offers both a consolidation of our current understanding and a view toward imminent therapeutic horizons.

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