Development of Composition and Technologies of Dental Gel of Meloxicam

Abstract

<jats:p>BACKGROUND: Dental gels have several advantages over other oral dosage forms. Being a viscoplastic dosage form, the gel, when applied to the damaged area of the gum or mucous membrane, creates a protective film, preventing mechanical irritation, and providing a localized effect of the drug components.&#x0D; AIM: The aim of this work was to develop the composition and technology of the dental gel of meloxicam, the study of the main technological and consumer characteristics, as well as the local irritating effect of the dosage form.&#x0D; METHODS: Dental gels were prepared using purified water, alcohol, glycerol, and buckthorn oil as solvents, gelling agents used were: Hydroxyethylcellulose Natrosol® 250 HHX Pharm, Carbopol® 974P NF Polymer, and solubilizer Poloxamer 407 (Lutrol® F 127). The bioadhesive component and Noveon® Polycarbophil component were used for dental gel preparation. Aspartame was used as sweetener. Menthol and ascorbic acid were used to correct the organoleptic properties of the pharmaceutical composition. The formulated dental gel of meloxicam at a concentration of 7.5% was evaluated for organoleptic properties, pH, rheological characteristics, bioadhesive properties, and stability under the accelerated aging period. The in vivo local irritant effect was evaluated using ten rabbits by cutaneous, subcutaneous, subconjunctival administration, as well as application to the upper palate.&#x0D; RESULTS: Based on the results of studying technological and organoleptic properties, the optimal composition based on the Natrosol® 250 HHX hydroxyethylcellulose gelling agent, glycerol solvent, and purified water in the ratio 1/5 was selected, the composition contains Noveon® bioadhesive in an amount of 2%. The composition has good taste, pH close to pH of saliva has high bioadhesive properties, satisfactory rheological characteristics. The shelf life of the experimental series by accelerated aging was 2 years. The selected composition does not have a local irritant effect.&#x0D; CONCLUSION: A new dosage form of meloxicam was developed – a gel for use in dental practice.</jats:p>

Investigating Bioactive-Glass-Infused Gels for Enamel Remineralization: An In Vitro Study

“…Next, the materials were filled into 60 mL PE tubes and closed. The blank gel (placebo), devoid of bioactive glass content, was prepared using the same method and used as a control for further tests [23]. Additionally, for stability testing, samples were placed in a laboratory dryer for a period of 2 months at 37 ± 2 • C. Stability testing under these conditions is crucial to simulate the shelf-life of the gels and predict their performance over time.…”

“…Tests were performed with a Mettler Toledo pH7110 SET instrument (Mettler Toledo sro, Prague, Czech Republic) equipped with a SenTix ® 81 electrode and 3 mol/L KCl buffer solutions. The instrument required daily calibration, which was performed prior to each test [23,27,28]. Five samples from each composition were tested, and averages were calculated, resulting in a total of 75 measurements across 3 time intervals (0-2 months).…”

“…This test is commonly employed for pasty materials, allowing for easy determination of how the material will behave after being squeezed out of the tube and whether it will remain on the applied surface [23].…”