Development of computerized adaptive testing (CAT) for the EORTC QLQ-C30 physical functioning dimension

Petersen, Morten Aa.; Grøenvold, Mogens; Aaronson, Neil K.; Chie, Wei‐Chu; Conroy, Thierry; Costantini, Anna; Fayers, Peter; Helbostad, Jorunn L.; Holzner, Bernhard; Kaasa, Stein; Schnittger, Susanne; Velikova, Galina; Young, Teresa

doi:10.1007/s11136-010-9770-x

Cited by 42 publications

(41 citation statements)

References 36 publications

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“…14). Efforts are also under way to use CAT with other instruments to measure physical function in cancer trials (15). Operationalizing the administration of CAT in large multinational trials may be challenging, and additional work is needed to better understand the strengths and limitations of CAT.…”

Section: Patient-reported Physical Functionmentioning

confidence: 99%

Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials: Symptomatic Adverse Events, Physical Function, and Disease-Related Symptoms

Kluetz

Slagle

Papadopoulos

et al. 2016

Clinical Cancer Research

269

222

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Cancer clinical trials have relied on overall survival and measures of tumor growth or reduction to assess the efficacy of a drug. However, benefits are often accompanied by significant symptomatic toxicities. The degree to which a therapy improves disease symptoms and introduces symptomatic toxicity affects how patients function in their daily lives. These concepts are important contributors to health-related quality of life (HRQOL). In this article, we discuss patient-reported outcome (PRO) assessment in cancer trials and challenges relying solely on static multi-item HRQOL instruments. We propose focusing on three separate measures of well-defined concepts: symptomatic adverse events, physical function, and disease-related symptoms, which are key contributors to the effect of a therapy on HRQOL. Separate measures of these three concepts may facilitate the incorporation of emerging contemporary instruments that can tailor the PRO assessment strategy to different trial contexts. Irrespective of the PRO measures used, continued improvement in trial design and conduct is crucial to decrease missing data and optimize the quality of PRO information. International stakeholder collaboration and continued research into optimal practices for PRO and other clinical outcome assessments are necessary to advance a common framework for generating and reporting rigorous patient-centered data from cancer clinical trials.

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Section: Patient-reported Physical Functionmentioning

confidence: 99%

Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials: Symptomatic Adverse Events, Physical Function, and Disease-Related Symptoms

Kluetz

Slagle

Papadopoulos

et al. 2016

Clinical Cancer Research

269

222

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“…The general steps in the development of the item banks for the CAT version of the EORTC QLQ-C30 have been described in detail previously (Giesinger et al, 2011;Petersen et al, 2012;Petersen et al, 2010;Petersen et al, 2011). The following summarises each step of the development of the pain item bank.…”

Section: Methodsmentioning

confidence: 99%

“…whether the DIF findings seemed to have practical consequences for pain estimation (Hart et al, 2009;Petersen et al, 2011). …”

Section: Test For Differential Item Functioning (Dif) Dif Analysimentioning

confidence: 99%

“…The European Organisation for Research and Treatment of Cancer Quality of Life Group (EORTC QLG) (http://groups.eortc.be/qol/) is carrying out a large scale project with the overall aim to improve the measurement of the health-related quality of life (HRQOL) domains included in the EORTC Quality of Life Questionnaire, the QLQ-C30 (Aaronson et al, 1993;Giesinger et al, 2011;Petersen et al, 2012;Petersen and Groenvold, 2013;Petersen et al, 2010;Petersen et al, 2011). This is achieved by developing a CAT measure for each domain in the EORTC QLQ-C30.…”

Section: Introductionmentioning

confidence: 99%

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Development of an item bank for computerized adaptive test (CAT) measurement of pain

et al. 2015

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Abstract:Background: Patient-reported outcomes should ideally be adapted to the individual patient while maintaining comparability of scores across patients. This is achievable using computerized adaptive testing (CAT). The aim here was to develop an item bank for CAT measurement of the pain domain as measured by the EORTC QLQ-C30 questionnaire. Methods: The development process consisted of four steps. 1) Literature search. 2) Formulation of new items. 3) Pre-testing. 4) Field-testing and psychometric analyses for the final selection of items. Results: In step 1) we identified 337 pain items from the literature. 2) Twenty-nine new items fitting the QLQ-C30 item style were formulated. Expert evaluations reduced this to 26 items. 3) Based on patient interviews (N=31) the list was further reduced to 21 items. 4) We obtained responses from 1,103 cancer patients from five countries. Psychometric evaluations showed that 16 items could be retained in a unidimensional item bank. Evaluations indicated that use of the CAT measure may reduce sample size requirements with 15-25% compared to using the QLQ-C30 pain scale. Conclusions: We have established an item bank of 16 items suitable for CAT measurement of pain. We recommend initiating CAT measurement by screening for pain using the two original QLQ-C30 pain items.

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“…The EORTC Quality of Life Group has adopted just such an approach, with its "core" QLQ-C30 questionnaire (a computer-adapted testing version and shortforms have also been developed [3]) covering 11 of the 12 core symptoms recommended [4] and condition-specific modules.…”

mentioning

confidence: 99%

Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials—Letter

Grøenvold

Aaronson

Darlington

et al. 2016

Clinical Cancer Research

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Development of computerized adaptive testing (CAT) for the EORTC QLQ-C30 physical functioning dimension

Abstract: We have established an item pool for CAT measurement of PF and believe that this CAT instrument will clearly improve the EORTC measurement of PF.

Cited by 42 publications

References 36 publications

Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials: Symptomatic Adverse Events, Physical Function, and Disease-Related Symptoms

Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials: Symptomatic Adverse Events, Physical Function, and Disease-Related Symptoms

Development of an item bank for computerized adaptive test (CAT) measurement of pain

Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials—Letter

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