Development of Cortical Surface Area and Gyrification in Attention-Deficit/Hyperactivity Disorder

Shaw, Philip; Malek, Meaghan; Watson, Bethany; Sharp, Wendy; Evans, Alan C.; Greenstein, Deanna

doi:10.1016/j.biopsych.2012.01.031

Cited by 316 publications

(275 citation statements)

References 59 publications

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“…We demonstrate that functional connectivity both within DMN and in DMN interconnections with two task-positive networks (FPN and VAN) is significantly lagged in ADHD. Previous longitudinal investigations of a large cohort of children found maturational lag of structural features of the brain in ADHD (3,(6)(7)(8). Our results demonstrate that there is also maturational lag in the brain's developing functional architecture, and it is relatively specific to connections within DMN and between DMN and TPNs.…”

Section: Discussionsupporting

confidence: 56%

“…One influential neurodevelopmental model of the disorder posits a lag in the maturational trajectories of key features of the brain (1-4). This model has mostly been investigated by examining developmental pathways of structural features of the brain (3,(5)(6)(7)(8). In recent years, however, theorists have increasingly used resting state functional MRI (fMRI)-scanning participants in a task-free resting state-to explore the brain's functional architecture.…”

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confidence: 99%

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Lag in maturation of the brain’s intrinsic functional architecture in attention-deficit/hyperactivity disorder

Sripada

Kessler

Angstadt

2014

Proc. Natl. Acad. Sci. U.S.A.

222

168

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Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood, and there is great interest in understanding its neurobiological basis. A prominent neurodevelopmental hypothesis proposes that ADHD involves a lag in brain maturation. Previous work has found support for this hypothesis, but examinations have been limited to structural features of the brain (e.g., gray matter volume or cortical thickness). More recently, a growing body of work demonstrates that the brain is functionally organized into a number of large-scale networks, and the connections within and between these networks exhibit characteristic patterns of maturation. In this study, we investigated whether individuals with ADHD (age 7.2-21.8 y) exhibit a lag in maturation of the brain's developing functional architecture. Using connectomic methods applied to a large, multisite dataset of resting state scans, we quantified the effect of maturation and the effect of ADHD at more than 400,000 connections throughout the cortex. We found significant and specific maturational lag in connections within default mode network (DMN) and in DMN interconnections with two task positive networks (TPNs): frontoparietal network and ventral attention network. In particular, lag was observed within the midline core of the DMN, as well as in DMN connections with right lateralized prefrontal regions (in frontoparietal network) and anterior insula (in ventral attention network). Current models of the pathophysiology of attention dysfunction in ADHD emphasize altered DMN-TPN interactions. Our finding of maturational lag specifically in connections within and between these networks suggests a developmental etiology for the deficits proposed in these models.resting state | connectomics | default network A ttention-deficit/hyperactivity disorder (ADHD) is a serious neuropsychiatric disorder characterized by inattention, hyperactivity, and impulsivity. One influential neurodevelopmental model of the disorder posits a lag in the maturational trajectories of key features of the brain (1-4). This model has mostly been investigated by examining developmental pathways of structural features of the brain (3,(5)(6)(7)(8). In recent years, however, theorists have increasingly used resting state functional MRI (fMRI)-scanning participants in a task-free resting state-to explore the brain's functional architecture. This work has led to the recognition that the human brain is organized into several large-scale intrinsic connectivity networks (ICNs), each associated with specific neurocognitive functions (9, 10). ICNs have been shown to undergo significant maturation from childhood to early adulthood, with individual ICNs exhibiting spatially specific reliable patterns of integration (increased connectivity with age) and segregation (decreased connectivity with age) with other ICNs (11-17). These advances raise possibilities for investigating maturational lag in ADHD in the developing ICN architecture of the brain (18).Independent lines of res...

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Section: Discussionsupporting

confidence: 56%

mentioning

confidence: 99%

Lag in maturation of the brain’s intrinsic functional architecture in attention-deficit/hyperactivity disorder

Sripada

Kessler

Angstadt

2014

Proc. Natl. Acad. Sci. U.S.A.

222

168

View full text Add to dashboard Cite

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“…Among boys with conduct disorder, such reductions in prefrontal gray matter are not observed (De Brito et al, 2009). In addition, children with ADHD evidence a considerable lag in neurodevelopment of the medial PFC compared with controls (Shaw et al, 2012). Such failures of prefrontal maturation likely have implications for difficulties with emotion regulation among those with externalizing behavior disorders (see Beauchaine & McNulty, 2013).…”

Section: Prefrontal Cortex Development Neural Plasticity and Emotiomentioning

confidence: 99%

Future Directions in Emotion Dysregulation and Youth Psychopathology

Beauchaine

2015

Journal of Clinical Child & Adolescent Psychology

317

321

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“…Preliminary reports show that ADHD children are on a different trajectory of brain maturation (Shaw et al 2012) that may also have impacted the functional connectivity within the cortico-striatal and ventral fronto-parietal networks. Alternatively, increased functional connectivity may also be related to compensatory mechanisms (for a similar interpretation in posterior cerebral atrophy see Migliaccio et al 2016).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Sanefuji

Craig

Parlatini

et al. 2017

Cortex

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Two core symptoms characterize Attention Deficit Hyperactivity Disorder (ADHD) subtypes: inattentiveness and hyperactivity-impulsivity. While previous brain imaging research investigated ADHD as if it was a homogenous condition, its two core symptoms may originate from different brain mechanisms. We, therefore, hypothesized that the functional connectivity of cortico-striatal and attentional networks would be different between ADHD subtypes. We studied 165 children (mean age 10.93 years; age range, 7-17 year old) diagnosed as having ADHD based on their revised Conner's rating scale score and 170 typical developing individuals (mean age 11.46 years; age range, 7-17 year old) using resting state functional fMRI. Groups were matched for age, IQ and head motion during the MRI acquisition. We fractionated the ADHD group into predominantly inattentive, hyperactive-impulsive and combined subtypes based on their revised Conner's rating scale score. We then analyzed differences in resting state functional connectivity of the cortico-striatal and attentional networks between these subtypes. We found a double dissociation of functional connectivity in the cortico-striatal and ventral attentional networks, reflecting the subtypes of the ADHD participants. Particularly, the hyperactive-impulsive subtype was associated with increased connectivity in cortico-striatal network, whereas the inattentive subtype was associated with increased connectivity in the right ventral attention network. Our study demonstrated for the first time a right lateralized, double dissociation between specific networks associated with hyperactivity-impulsivity and inattentiveness in ADHD children, providing a biological M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 2 basis for exploring symptom dimensions and revealing potential targets for more personalized treatments.

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Development of Cortical Surface Area and Gyrification in Attention-Deficit/Hyperactivity Disorder

Cited by 316 publications

References 59 publications

Lag in maturation of the brain’s intrinsic functional architecture in attention-deficit/hyperactivity disorder

Lag in maturation of the brain’s intrinsic functional architecture in attention-deficit/hyperactivity disorder

Future Directions in Emotion Dysregulation and Youth Psychopathology

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

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