Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications

Singh, Baljit; Sharma, Vikrant; Rajneesh, -; Kumar, Ajay; Rohit, .; Mohan, Man; Kumar, Rajender; Kumari, Ankita; Sharma, Prerna; Ram, Kaka

doi:10.1016/j.fhfh.2022.100095

Cited by 7 publications

(5 citation statements)

References 74 publications

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“…The inclusive trend shows higher swelling at lower pH (PBS 5.5) than at high pH (PBS 7.4) at a given time interval [30] . Baljit Singh et al synthesized a hydrogel using Moringa oleifera gum and Sterculia gum in which the least swelling was observed (2.94 g/g) in pH 2.2 buffer in 24 hours [49] …”

Section: Resultsmentioning

confidence: 99%

“…A relatable research article published by Wu et al in which an injectable hydrogel was fabricated using Schiff base chemistry and 5‐fluoroanil drug release studies reported that high release was observed at pH 6.0 (80 % FU) than at PBS 7.0 (58.9 %) [50] . Baljit Singh et al fabricated a hydrogel using Moringa oleifera gum and Sterculia gum in which the least release of levofloxacin drug was observed (60.387 mg/L) in pH 2.2 buffer and follows non‐Fickian diffusion [49] …”

Section: Resultsmentioning

confidence: 99%

“…[30] Baljit Singh et al a hydrogel using Moringa oleifera gum and Sterculia gum in which the least swelling was observed (2.94 g/g) in pH 2.2 buffer in 24 hours. [49]…”

Section: Swelling Study From Gel Form Of Ih (Methods 2)mentioning

confidence: 99%

“…[50] Baljit Singh et al fabricated a hydrogel using Moringa oleifera gum and Sterculia gum in which the least release of levofloxacin drug was observed (60.387 mg/L) in pH 2.2 buffer and follows non-Fickian diffusion. [49]…”

Section: Drug Release From Dry Hydrogel (Method-1)mentioning

confidence: 99%

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Self‐Healing, Biocompatible Injectable Hydrogel Based on Multialdehyde Moringa oleifera Gum and Carboxymethyl Chitosan: A Suitable Platform for Drug Delivery in Wound Healing Application

Kumar,

Purwar

2024

ChemistrySelect

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This study focuses on synthesizing an injectable hydrogel (IH) using Moringa oleifera gum (MOG) with multi‐aldehyde groups (MOG‐CHO) and carboxymethyl chitosan (CMCh) through a Schiff base reaction at 37 °C. The study includes the optimal concentration of the oxidizing agent to achieve the best content of aldehydes in Moringa oleifera gum. Furthermore, the best oxidized Moringa oleifera gum decides the least gelation time. The physical properties of the optimized IH (IH‐3‐7) are assessed, including color, gel content, porosity, load‐bearing capacity, syringeability, and self‐healing capability. Structural characterization is performed using Fourier transform Infrared spectroscopy (FT‐IR) and nuclear magnetic spectroscopy (1H NMR), while scanning electron microscope (SEM) and rheometer are used to analyze surface morphology and rheological properties. IH‐3‐7 exhibits a porous structure with 35 % porosity and interconnected holes of 1.45 to 4 μm diameter. Higher swelling at pH 5.5 is shown by swelling ratio test conducted in phosphate buffer saline (PBS) at pH 7.4 and pH 5.5. Ciprofloxacin HCl (Cipro) is loaded into IH for release assays, revealing pH‐dependent drug release. In vitro, cytotoxicity assessments on L‐929 fibroblast cell lines show IH′s biocompatibility. Hydrolytic degradation of IH in PBS at pH 7.4 is also evaluated.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…[30] Baljit Singh et al a hydrogel using Moringa oleifera gum and Sterculia gum in which the least swelling was observed (2.94 g/g) in pH 2.2 buffer in 24 hours. [49]…”

Section: Swelling Study From Gel Form Of Ih (Methods 2)mentioning

confidence: 99%

Section: Drug Release From Dry Hydrogel (Method-1)mentioning

confidence: 99%

See 2 more Smart Citations

Self‐Healing, Biocompatible Injectable Hydrogel Based on Multialdehyde Moringa oleifera Gum and Carboxymethyl Chitosan: A Suitable Platform for Drug Delivery in Wound Healing Application

Kumar,

Purwar

2024

ChemistrySelect

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“…Gastroretentive drug delivery systems (GRDDS) are used for site-specific drug release and systematic action in the upper part of the gastrointestinal tract (GIT) specially for the drugs having absorption window in the stomach [1,2] and local action for treatment of the inflammatory or cancerous diseases and eradication Helicobacter pylori [3,4]. There are several technologies to achieve increasing drug residence in the upper part of the GIT, such as magnetic systems [5], mucoadhesive systems [6,7], expandable systems [8], floating systems [9,10], high-density systems [11,12], polymeric fibrous [13,14] and ion-exchange resins [15].…”

Section: Introductionmentioning

confidence: 99%

New Carriers for Bioadhesive Gastroretentive Drug Delivery Systems Based on Eudragit® EPO/Eudragit® L100 Interpolyelectrolyte Complexes

Gordeeva,

Sitenkova (Bukhovets),

Moustafine

2023

Preprint

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Interpolyelectrolyte complexes Eudragit® EPO/L100 received in different pH were characterized by different degree of swelling in mimicking fasted stomach medium (0.1 M HCl) and saved their shape during 6 hours of the experiment. The microenvironmental changes in IPECs structure during swelling testing were inves-tigated using FT-IR spectroscopy, thermal and elemental analysis. Both samples of IPECs during swelling were transformed to a similar structure with approximately the same composition. IPEC samples showed bioadhesive properties that was not significantly different from the positive control (Carbopol) in the test with the mucin compacts. The release rate of metronidazole (class I BCS) from IPEC matrices increased with the increasing degree of swelling. IPEC 1 provided 49.62 ± 6.20% and IPEC 2 – 87.69 ± 5.15 % of metronidazole release after 6 hours in mimicking fasted stomach medium (0.1 M HCl). Total amount of released acyclovir (class III BCS) from IPEC 1 was 25.76 ± 5.67 % and from IPEC 2 was 21.48 ± 5.00 %. Release of both drugs was controlled by relaxation of polymeric chains in matrices according to the Peppas-Sahlin model. According to the received results, investigated interpolymer complexes are perspective for further evalua-tion as carriers for gastroretentive bioadhesive systems.

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A comparison of controlled release from cyclodextrin mediated and non-mediated hydrogel matrices of Moringa Oleifera gum and carboxymethyl cellulose

Kaur,

Anmol

et al. 2024

Polym. Bull.

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Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications

Cited by 7 publications

References 74 publications

Self‐Healing, Biocompatible Injectable Hydrogel Based on Multialdehyde Moringa oleifera Gum and Carboxymethyl Chitosan: A Suitable Platform for Drug Delivery in Wound Healing Application

Self‐Healing, Biocompatible Injectable Hydrogel Based on Multialdehyde Moringa oleifera Gum and Carboxymethyl Chitosan: A Suitable Platform for Drug Delivery in Wound Healing Application

New Carriers for Bioadhesive Gastroretentive Drug Delivery Systems Based on Eudragit® EPO/Eudragit® L100 Interpolyelectrolyte Complexes

A comparison of controlled release from cyclodextrin mediated and non-mediated hydrogel matrices of Moringa Oleifera gum and carboxymethyl cellulose

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