Development of dual-functional core-shell electrospun mats with controlled release of anti-inflammatory and anti-bacterial agents for the treatment of corneal alkali burn injuries

Razavi, Malihe Sadat; Ebrahimnejad, Pedram; Javar, Hamid Akbari; Weppelmann, Thomas A.; Akbari, Jafar; Amoli, Fahimeh Asadi; Atyabi, Fatemeh; Dinarvand, Rassoul

doi:10.1016/j.bioadv.2023.213648

Cited by 6 publications

(2 citation statements)

References 102 publications

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“…However, our study provides a more comprehensive analysis of the structural impact of Curcumin NPs. 54,55 Fig. 7 illustrates the pathological results obtained from H&E staining.…”

Section: Pathology Resultsmentioning

confidence: 99%

“…The Curcumin NPs into Hyaluronic acid-based hydrogel treatment and the NAC treatment group had the least amount of these cytokines that showed the improvement of in ammation. Earlier research has shown that Curcumin NPs can reduce TNF-α and IL-6 levels in corneal and skin wound healing [55][56][57] , and HA hydrogel reduces IL-6 and TNFα in skin wound healing and corneal in ammation. 14,59,60 Previous research has demonstrated that curcumin can reduce angiogenesis in pterygium, an in ammatory disease in the cornea, by decreasing the expression and secretion of IL-6.…”

Section: Cytokine Measurement Resultsmentioning

confidence: 99%

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The Effect of Topical Curcumin Nanoparticles Encapsulated with β- Cyclodextrin into Hyaluronic Acid-Based Hydrogel Complex on Experimental Ulcerative Keratitis in Comparison with N-Acetylcysteine in Rabbit Model

Sohani,

Jamshidi,

Koohi

et al. 2024

Preprint

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Corneal ulcers, whether melting or indolent, are common in humans and companion animals. Treatment involves local administration of antibiotic eye drops and corneal healing drugs. Compared to traditional treatments for ulcerative keratitis, herbal medicines have unique advantages, such as potent anti-inflammatory effects and inhibition of proinflammatory cytokines. Curcumin, extracted from the Curcuma Longa plant, possesses extensive pharmacological properties, such as anti-inflammatory, anti-cancer, and antioxidant properties, and is used in various medicines. In this study, using a formulation of Curcumin NPs encapsulated with β-cyclodextrin and hyaluronic acid, an ophthalmic drop hydrogel was developed to accelerate corneal healing and improve the quality of healed structures. The formation of Curcumin NPs into Hyaluronic acid-based hydrogels was characterized by Fourier transform infrared (FTIR), zeta, and scanning electron microscope (SEM) analyses. A total of 25 healthy male New Zealand Albino rabbits were experimentally induced with ulcerative keratitis and treated individually with topical medication. Rabbits were divided into five groups. Fluorescein dye staining, corneal clarity score, Schirmer tear test, proinflammatory cytokine measurement, and pathologic factors assessments were used to evaluate the optimised Curcumin NPs with β-cyclodextrin in Hyaluronic acid hydrogel. Intriguingly, the frequency of administering medication is reduced compared to conventional therapies, which enhances the quality of healed structures and harnesses ulcerative keratitis. (p<0.05) All findings in this study provide new insight into designing and fabricating novel ophthalmic medicine for ulcerative keratitis for topical usage.

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“…However, our study provides a more comprehensive analysis of the structural impact of Curcumin NPs. 54,55 Fig. 7 illustrates the pathological results obtained from H&E staining.…”

Section: Pathology Resultsmentioning

confidence: 99%