Development of enzymatically degradable protective coatings for use in triggered drug delivery systems: derivatized starch hydrogels

Heller, Jorge; Pangburn, Sharon; Roskos, K.V.

doi:10.1016/0142-9612(90)90112-4

Cited by 56 publications

(25 citation statements)

References 5 publications

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“…Triggered delivery of the morphine antagonist naltrexone [16590- has been explored by several groups. A device containing naltrexone dispersed in a biodegradable polymer core, eg, a partially esterified copolymer of methyl vinyl ether [107-25-5] and maleic anhydride [108-31-6] that is stable at low pH but erodes rapidly at pH 7.4 (a physiologic pH), has been described (126) (Fig. 13).…”

Section: Triggered and Closed-loop Deliverymentioning

confidence: 99%

Controlled Release Technology, Pharmaceutical

Edgren

Leeper

Nichols

et al. 2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Controlled-release dosage forms enhance the safety, efficacy, and reliability of drug therapy. They regulate the drug release rate to control drug action and reduce the frequency of drug administration to encourage patients to comply with dosing instructions. Conventional dosage forms often lead to wide swings in serumdrug concentrations. Most of the drug content is released soon after administration, causing drug levels in the body to rise rapidly, peak, and then decline sharply. For drugs whose actions correlate with their serumdrug concentration, these sharp fluctuations often cause unacceptable side effects at the peaks, followed by inadequate therapy at the troughs (Fig. 1). Administering smaller doses at more frequent intervals can damp concentration fluctuations, preventing over-and underdosing, but the inconvenience may cause patients to skip or delay doses, degrading efficacy. Compliance, measured as the percentage of patients taking 95% to 105% of prescribed oral medications, decreased from 67% with once-a-day regimens to 22% with four-times-a-day regimens (1). These difficulties are especially pronounced with drugs that have short half-lives and a narrow range of safe and effective concentrations. Precisely controlled release is particularly valuable for such agents (see Drug delivery systems).The term controlled release technology generally refers to a variety of methods used to exert various degrees of control over drug release. The U.S. Food and Drug Administration (FDA) defines controlled release dosage forms as those formulations designed to release active ingredient(s) at rates that differ significantly from their corresponding immediate release forms (2). The indexing system of Index Medicus supports this broad definition by classifying these dosage forms as delayed-action preparations, and Excerpta Medica uses the index term sustained release preparations. The pharmaceutical literature contains a profusion of terms, including delayed-action, extended action, gradual release, prolonged release, protracted release, slow release, sustained release, depot, retard, and timed-release dosage forms, all emphasizing an increased duration of action (3).To avoid confusion, several researchers have incorporated therapeutic intention into the definition of controlled release (4-7). Thus, controlled-release pharmaceuticals release drugs in vivo according to a predictable, therapeutically rational, programmed rate to achieve the optimal drug concentration in the minimal time (4). Specification by release rate complements specification by quantity; jointly considered, they fix the duration of drug release. Therefore, the drug's duration of action can become a design property of a controlled release dosage form rather than an inherent pharmacokinetic property of the drug molecule.Under this more precise definition, controlled release drug delivery not only provides a predictable, patterned action, but controls the rate of drug release for a predetermined period. Controlled release systems deliver drugs at a con...

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Section: Triggered and Closed-loop Deliverymentioning

confidence: 99%

Controlled Release Technology, Pharmaceutical

Edgren

Leeper

Nichols

et al. 2000

Kirk-Othmer Encyclopedia of Chemical Technology

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“…The controlled release of drugs from amylose gels has been studied in order to develop new drug delivery systems [1][2][3] . It is indispensable to elucidate the mechanism of the diffusion process of molecules contained in the amylose gels for controlling the material-release out of the gels.…”

Section: Introductionmentioning

confidence: 99%

Preparation of amylose gel and probe diffusion through the gel membranes

Yasunaga

Matsumoto

Kitamura

2000

Macromol. Rapid Commun.

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“…It occurs majorly in plants where they act as storage materials. Chemically, it is composed of recurring units of glycopyranose in an alpha D-(1, 4) linkage and on hydrolysis yields the monosaccharide, glucose (Heller et al, 1990). The use of starch in pharmaceutics is extensive.…”

Section: Starchmentioning

confidence: 99%

“…The use of starch in pharmaceutics is extensive. It is used as co-polymer and excipient in controlled drug delivery (74 -76) as drug carriers in tissue engineering scaffolds (77) as Hydrogels (78) and as solubility enhancers (79).…”

Section: Starchmentioning

confidence: 99%